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Extraction of Fatty Oil from Milk Thistle Fruits with Supercritical Carbon Dioxide

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Abstract

Milk thistle [Silybum marianum (L.) Gaertn], which grows in the Dagestan Republic, is a promising raw material for the preparation of broad-spectrum medicines. Milk thistle fruit oil as a source of higher polyunsaturated carboxylic acids has anti-inflammatory, wound-healing, regenerating, and antioxidant activities. Supercritical fluid extraction of fatty oil from milk thistle fruits with carbon dioxide is optimized using a full-factorial second-order rotatable design. The influence of pressure, temperature, and duration of the process on the extract yield iss evaluated. According to the model used, the optimum conditions are pressure 41.8 MPa, temperature 70°C, and extraction time of 140 min. When conducting a confirmation experiment under these conditions, the extract yield is 25.9 %, which is only 0.5% smaller than the maximum yield obtained by exhaustive extraction with n-hexane. The relative error of the model is 1.5%.

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Authors and Affiliations

  1. Dagestan State University, Makhachkala, Dagestan, Russia

    A. Sh. Ramazanov & Sh. A. Balaeva

  2. Institute of Geothermal and Renewable Energy Problems, Branch of the Joint Institute of High Temperatures, Russian Academy of Sciences, Makhachkala, Dagestan, Russia

    A. Sh. Ramazanov

Authors
  1. A. Sh. Ramazanov
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  2. Sh. A. Balaeva
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Correspondence to A. Sh. Ramazanov.

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Translated by N. Smolina

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Ramazanov, A.S., Balaeva, S.A. Extraction of Fatty Oil from Milk Thistle Fruits with Supercritical Carbon Dioxide. Russ. J. Phys. Chem. B 15, 1207–1214 (2021). https://doi.org/10.1134/S1990793121070125

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  • DOI: https://doi.org/10.1134/S1990793121070125

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