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Micronization of Levofloxacin Using the RESS Method

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Abstract

The antibacterial drug levofloxacin (LF) is micronized by the Rapid Expansion of the Supercritical Solution (RESS) method to obtain microparticles with a high level of bioavailability. Ethanol is used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF microparticles with the characteristic size of <10 microns are obtained.

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REFERENCES

  1. R. K. Kankala, Yu. S. Zhang, S. B. Wang, C. H. Lee, and Z. Ai-Chen, Adv. Healthcare Mater. 6, 1700433 (2017).

    Article  Google Scholar 

  2. D. Yu. Zalepugin, N. A. Til’kunova, I. V. Chernyshova, and V. S. Polyakov, Sverkhkrit. Flyuidy: Teor. Prakt. 1 (1), 27 (2006).

    Google Scholar 

  3. I. Pasquali and R. Bettini, Int. J. Pharm. 364, 176 (2008).

    Article  CAS  Google Scholar 

  4. A. G. Samoilova, I. A. Vasil’eva, T. R. Bagdasaryan, and S. V. Moiseeva, Med. Obozren., No. 19, 973 (2013).

  5. A. I. Sinopal’nikov, Klin. Med. 94, 11 (2016).

    Google Scholar 

  6. A. M. Nareddin, W. F. Elkhatib, K. M. Cunnion, and G. G. Zhanel, Drug Health Patient. Saf. 3, 59 (2001).

    Google Scholar 

  7. K. Moribe, Y. Tozuka, and K. Yamamoto, Adv. Drug Deliv. Rev. 60, 32 (2008).

    Article  Google Scholar 

  8. S. E. Bogorodskii, L. I. Krotova, S. A. Minaeva, G. V. Mishakov, V. K. Popov, Yu. B. Basyuk, and V. I. Sevast’yanov, Perspekt. Mater., No. 1, 23 (2013).

  9. M. Turk, P. Hils, B. Helfgen, K. Schaber, H. J. Martin, and M. A. Wahl, J. Supercrit. Fluids 22, 75 (2002).

    Article  CAS  Google Scholar 

  10. E. Reverchon and E. Adami, J. Supercrit. Fluids 37, 1 (2006).

    Article  CAS  Google Scholar 

  11. D. Hermsdorf, S. Jauer, and R. Signorell, Mol. Phys. 105, 951 (2007).

    Article  CAS  Google Scholar 

  12. I. M. Gimul’tdinov, A. N. Sabirzyanov, and F. M. Gumerov, Sverkhkrit. Flyuidy: Teor. Prakt. 3 (1), 43 (2008).

    Google Scholar 

  13. I. M. Gil’mutdinov, V. F. Khairutdinov, I. V. Kuznetsova, A. A. Mukhamadiev, F. R. Gabitov, F. M. Gumerov, and A. N. Sabirzyanov, Russ. J. Phys. Chem. B 3, 1145 (2009).

    Article  Google Scholar 

  14. A. Z. Hezave, S. Aftab, and F. Esmaeilzadeh, J. Supercrit. Fluids 55, 316 (2010).

    Article  CAS  Google Scholar 

  15. A. Fattahi, J. Karimi-Sabet, A. Keshavarz, A. Golzary, M. Rafiee-Tehrani, and F. A. Dorkoosh, J. Supercrit. Fluids 107, 469 (2016).

    Article  CAS  Google Scholar 

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Funding

The work was supported by the Ministry of Science and Higher Education as part of a state order for the Federal Research Center “Crystallography and Photonics” of the Russian Academy of Sciences for the development of SCF techniques for micronizing bioactive substances and by the Russian Foundation for Basic Research (project no. 18-29-06062 mk) for the production of micron-sized spherical particles of levofloxacin.

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Authors and Affiliations

  1. Institute of Photonic Technology, Federal Research Center “Crystallography and Photonics,” Russian Academy of Sciences, 108840, Moscow, Russia

    E. N. Antonov, L. I. Krotova, G. V. Mishakov & V. K. Popov

Authors
  1. E. N. Antonov
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  2. L. I. Krotova
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  3. G. V. Mishakov
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  4. V. K. Popov
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Corresponding author

Correspondence to G. V. Mishakov.

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Translated by E. V. Makeeva

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Antonov, E.N., Krotova, L.I., Mishakov, G.V. et al. Micronization of Levofloxacin Using the RESS Method. Russ. J. Phys. Chem. B 14, 1225–1228 (2020). https://doi.org/10.1134/S1990793120070210

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  • DOI: https://doi.org/10.1134/S1990793120070210

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