Russian Journal of Physical Chemistry B

, Volume 10, Issue 7, pp 1085–1091

Hydrolysis of aralosides from Manchurian aralia to oleanolic acid and its derivatives in subcritical water

  • O. V. Filonova
  • A. V. Lekar
  • S. N. Borisenko
  • E. V. Vetrova
  • E. V. Maksimenko
  • N. I. Borisenko
  • V. I. Minkin
Article

Abstract

A method for preparing oleanolic acid (OA) and its derivatives by the hydrolysis of aralosides from Manchurian aralia in subcritical water has been developed. It has been used for the treatment of the Saparal pharmaceutical preparation at 120–240°C in a static regime. The maximal yield of OA has been obtained at 210°C.

Keywords

subcritical water aralosides Manchurian aralia saponins saparal oleanolic acid HPLC–MS 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    K. A. Hostettmann and A. Marston, Saponins. Chemistry and Pharmacology of Natural Products (Cambridge Univ. Press, Cambridge, UK, 1995).Google Scholar
  2. 2.
    D. A. Murav’eva, I. A. Samylina, and G. P. Yakovlev, Pharmacognosy, 4th ed. (Meditsina, Moscow, 2002) [in Russian].Google Scholar
  3. 3.
    S. A. Minina and I. E. Kaukhova, Chemistry and Technology of Herbal Remedies, The School-Book for Higher Schools (Geotar-Med, Moscow, 2004) [in Russian].Google Scholar
  4. 4.
    L. O. Somova, A. Nadar, P. Rammanan, and F. O. Shode, Phytomedicine 10, 115 (2003).CrossRefGoogle Scholar
  5. 5.
    G. B. Iskenderov, Khim. Farm. Zh., No. 2, 55 (1990).Google Scholar
  6. 6.
    S. Shishodia, S. Majumdar, S. Banerjee, and B. B. Aggarwal, Cancer Res. 63, 4375 (2003).Google Scholar
  7. 7.
    J. Liu, J. Ethnopharmacol. 49, 57 (1995).CrossRefGoogle Scholar
  8. 8.
    H. Tokuda, H. Ohigashi, K. Koshimizu, and Y. Ito, Cancer Lett. 33, 279 (1986).CrossRefGoogle Scholar
  9. 9.
    H. Y. Lee, H. Y. Chung, K. H. Kim, J. J. Lee, and K. W. Kim, J. Cancer Res. Clin. Oncol. 120, 513 (1994).CrossRefGoogle Scholar
  10. 10.
    L. B. Mal’chukovskii and N. I. Libizov, Farmatsiya, No. 2, 68 (1971).Google Scholar
  11. 11.
    I. Desta, E. T. Oganesyan, and E. F. Shvets, Farmatsiya, No. 6, 12 (1981).Google Scholar
  12. 12.
    K. Xiao, Y. H. Yi, Z. Z. Wang, H. F. Tang, and Y. Q. Li, J. Nat. Prod. 62, 1030 (1999).CrossRefGoogle Scholar
  13. 13.
    N. V. Vasil’eva, T. A. Smolina, and V. K. Timofeeva, Organic Synthesis, The School-Book for Higher Schools (Prosveshchenie, Moscow, 1986) [in Russian].Google Scholar
  14. 14.
    A. F. Bochkov, V. A. Afanas’ev, and G. E. Zaikov, The Formation and Cleavage of Glycosidic Bonds (Nauka, Moscow, 1978) [in Russian].Google Scholar
  15. 15.
    J. D. Taylor, J. I. Steinfeld, and J. W. Tester, Ind. Eng. Chem. Res. 40, 67 (2001).CrossRefGoogle Scholar
  16. 16.
    C. M. Comisar and P. E. Savage, Green Chem. 6, 227 (2004).CrossRefGoogle Scholar
  17. 17.
    A. A. Galkin and V. V. Lunin, Russ. Chem. Rev. 74, 21 (2005).CrossRefGoogle Scholar
  18. 18.
    K. S. Tikhomirova, A. V. Lekar, S. N. Borisenko, N. I. Borisenko, and V. I. Minkin, Russ. J. Phys. Chem. B 4, 1125 (2010).CrossRefGoogle Scholar
  19. 19.
    O. V. Filonova, A. V. Lekar, S. N. Borisenko, E. V. Maksimenko, E. V. Vetrova, N. I. Borisenko, and V. I. Minkin, Russ. J. Phys. Chem. B 9, 1153 (2015).CrossRefGoogle Scholar
  20. 20.
    State Pharmacopoeia of USSR, 11th ed. (Meditsina, Moscow, 1990), No. 2 [in Russian].Google Scholar
  21. 21.
    E. Ya. Ladygina, N. I. Grinkevich, and L. N. Safronich, Chemical Analysis of Drugs, The School-Book for Pharmaceutical Higher Schools and Departments (Vyssh. Shkola, Moscow, 1983) [in Russian].Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • O. V. Filonova
    • 1
  • A. V. Lekar
    • 1
  • S. N. Borisenko
    • 1
  • E. V. Vetrova
    • 1
  • E. V. Maksimenko
    • 1
  • N. I. Borisenko
    • 1
  • V. I. Minkin
    • 1
  1. 1.Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-DonRussia

Personalised recommendations