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The effect of St. John’s wort supercritical extract and hyperforin solution on biological subjects

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Abstract

The biological activity of supercritical fluid (SCF) extracts of St. John’s wort and hyperforin solutions isolated from these extracts has been studied relative to both prokaryotic (standard bacteria strains) and eukaryotic (yeast and sea urchin gametes and zygotes). A pronounced toxicity of the hyperforin solution in relation to the blue pus bacillus Pseudomonas aeruginosa was observed. No antimicrobial activity of the same solution with respect to other tested bacteria and yeast was revealed. In addition, the toxicities of both the hyperforin solution and total St. John’s wort SCF extract for sperm cells and zygotes of sea urchin were registered. Addition of the SCF extract to a culture of growing embryos does not affect fertilization and division, but cell development terminates at an early gastrula stage. This indicates that the extract damages the genome transcription process in the zygotes.

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References

  1. State Register of Medicines, Official edition (Moscow, 2004), Vol. 1 [in Russian].

  2. V. Butterweck, G. Jurgenliemk, A. Nahrstedt, and H. Winterhoff, Planta Medica 66, 3 (2000).

    Article  CAS  Google Scholar 

  3. J. Barnes, L. A. Anderson, and J. D. Phillipson, J. Pharm. Pharmacol. 53, 583 (2001).

    Article  CAS  Google Scholar 

  4. P. J. Mansky and S. E. Straus, J. Natl. Cancer Inst. (Bethesda) 94, 1157 (2002).

    Article  Google Scholar 

  5. M. Dona, I. DellAica, E. Pezzato, L. Sartor, F. Calabrese, M. Della Barbera, A. Donella-Deana, G. Appendino, A. Borsarini, R. Caniato, and S. Garbisa, Cancer Res. 64, 6225 (2004).

    Article  CAS  Google Scholar 

  6. C. M. Schempp, K. Pelz, A. Wittmer, E. Schopf, and J. C. Simon, Lancet. 353, 2129 (1999).

    Article  CAS  Google Scholar 

  7. G. M. Kitanov and K. F. Blinova, Khim. Prir. Soedin., No. 2, 185 (1987).

    Google Scholar 

  8. O. E. Pravdivtseva and V. A. Kurkin, Khim. Rastit. Syr’ya, No. 1, 81 (2008).

    Google Scholar 

  9. P. J. Nathan, Psychopharmacology. 15, 47 (2001).

    Article  CAS  Google Scholar 

  10. W. E. Muller, St. John’s Wort and Its Active Principles in Depression and Anxiety (Birkhauser, Berlin, Basel, Boston, 2005).

    Book  Google Scholar 

  11. M. A. Medina, B. Martinez-Poveda, M. I. Amores-Sanchez, and A. R. Quesada, Life Sci. 79, 105 (2006).

    Article  CAS  Google Scholar 

  12. G. Di Carlo, F. Borrelli, E. Ernst, and A. A. Izzo, Trends Pharmacol. Sci. 22, 292 (2001).

    Article  CAS  Google Scholar 

  13. V. Butterweck, CNS Drugs. 17, 539 (2003).

    Article  CAS  Google Scholar 

  14. E. Ernst, Lancet. 354, 2014 (1999).

    Article  CAS  Google Scholar 

  15. C. Y. W. Ang, L. Hu, T. M. Heinze, Y. Cui, J. P. Freeman, K. Kozak, W. Luo, F. F. Liu, A. Mattia, and M. J. DiNovi, Agric. Food. Chem. 52, 6156 (2004).

    Article  CAS  Google Scholar 

  16. V. Butterwecka, V. Christoffel, A. Nahrstedt, F. Petereit, B. Spengler, and H. Winterhoff, Life Sci. 73, 627 (2003).

    Article  Google Scholar 

  17. M. Mannila, H. Kim, C. Isaacson, and C. M. Wai, Green Chem. 4, 331 (2002).

    Article  Google Scholar 

  18. S. Glisic, A. Smelcerovic, S. Zuehlke, M. Spiteller, and D. Skala, J. Supercrit. Fluids. 45, 332 (2008).

    Article  CAS  Google Scholar 

  19. D. Cossuta, T. Vatai, M. Bathori, J. Hohmann, T. Keve, and B. J. Simandi, Food Proc. Eng. 35, 222 (2012).

    Article  CAS  Google Scholar 

  20. O. J. Catchpole, N. B. Perry, B. M. T. Silva, J. B. Grey, and B. M. Smallfield, J. Supercrit. Fluids. 22, 129 (2002).

    Article  CAS  Google Scholar 

  21. M. Mannila, Q. Lang, Ch.M. Wai, Y. Cui, and C. Y. W. Ang, in Supercritical Carbon Dioxide, Eds. by A. Gopalan et al., ACS Symposium Ser. (Amer. Chem. Soc., Washington DC, 2003).

    Google Scholar 

  22. H. C. J. Orth, C. Rentel, and P. C. Schmidt, J. Pharm. Pharmacol. 51, 193 (1999).

    Article  CAS  Google Scholar 

  23. A. S. Samokhin, I. A. Revel’skii, D. A. Chepelyanskii, O. O. Parenago, O. I. Pokrovskii, F. D. Lepeshkin, K. B. Ustinovich, and A. I. Revel’skii, Sverkhkrit. Fluidy Teor. Prakt. 6 (4), 22 (2011).

    Google Scholar 

  24. P. A. Dinnel, Biol. Morya. 21, 390 (1995).

    Google Scholar 

  25. N. Kobayasi, T. Kh. Naidenko, and M. A. Vashchenko, Biol. Morya. 20, 457 (1994).

    Google Scholar 

  26. S. Manzo, Ecotoxicol. Environ. Safety. 57, 123 (2004).

    Article  CAS  Google Scholar 

  27. M. N. Semenova, A. Kiselyov, and V. V. Semenov, Bio Techniques. 40, 1 (2006).

    Google Scholar 

  28. G. A. Buznikov, L. A. Nikitina, L. M. Raki, I. Milosevi, V. V. Bezuglov, J. M. Lauder, and Th.A. Slotkin, Brain Res. Bull 2003. 74, 221 (2007).

    Article  Google Scholar 

  29. C. Azoro, World J. Biotechnol. 3, 347 (2002).

    Google Scholar 

  30. M. C. Sharma and S. Sharma, Int. J. Microbiol. Res. 1, 162 (2010).

    Google Scholar 

  31. H. Yamamoto and T. Ogawa, Boisci. Biotechnol. Biochem. 66, 921 (2002).

    Article  CAS  Google Scholar 

  32. M. Panghal, V. Kaushal, and J. P. Yadav, Ann. Clin. Microbiol. Antimicrob. 10 (21) (2011). doi:10.1186/1476-0711-10-21

    Google Scholar 

  33. K. Botzenhart and G. Doring, in Pseudomonas Aeruginosa as an Opportunistic Pathogen, Eds. by M. Campa, M. Bendinelli, and H. Friedman (Plenum Press, New York, 1993), pp. 1–18.

  34. Yu.K. Abaev, E. I. Gudkova, V. I. Volkova, I. I. Slabko, and A. A. Adarchenko, Med. Zh., No. 3, 29 (2005).

    Google Scholar 

  35. M. Mehta, J. N. Punia, and R. M. Joshi, Ind. J. Med. Microbiol. 19, 232 (2001).

    CAS  Google Scholar 

  36. X. Bertrand, G. Blasco, E. Belle, A. Boillot, G. Capellier, and D. Talon, Ann. Fr. Anesth. Reanim. 22, 505 (2003).

    Article  CAS  Google Scholar 

  37. R. K. Flamm, M. K. Weaver, C. Thornsberry, M. E. Jones, J. A. Karlowsky, and D. F. Sahm, Antimicrob. Agents Chemother. 48, 2431 (2004).

    Article  CAS  Google Scholar 

  38. K. O. Okon, P. C. Agukwe, W. Oladosu, S. T. Balogun, and A. Uba, Int. J. Microbiol. 8(2) (2010).

    Google Scholar 

  39. K. N. Gaind and T. N. Ganjoo, Ind. J. Pharmacy. 21, 172 (1959).

    Google Scholar 

  40. A. I. Gurevich, V. N. Dobrynin, M. N. Kolosov, S. A. Popravko, and I. D. Ryabova, Antibiotiki. 16, 510 (1971).

    CAS  Google Scholar 

  41. N. S. Bystrov, B. K. Chernov, V. N. Dobrynin, and M. N. Kolosov, Tetrahedron Lett. 32, 2791 (1975).

    Article  Google Scholar 

  42. C. M. Schempp, K. Pelz, A. Wittmer, E. Schopf, and J. C. Simon, Lancet. 353 (9170), 2129 (1999).

    Article  CAS  Google Scholar 

  43. C. M. Schempp, B. Winghofer, R. Ludtke, B. Simon-Haarhaus, E. Schopf, and J. C. Simon, Brit. J. Dermatol. 142, 979 (2000).

    Article  CAS  Google Scholar 

  44. C. M. Schempp, V. Kirkin, B. Simon-Haarhaus, A. Kersten, J. Kiss, C. C. Termeer, B. Gilb, T. Kaufmann, C. Borner, J. P. Sleeman, and J. C. Simon, Oncogene. 21, 1242 (2002).

    Article  CAS  Google Scholar 

  45. C. M. Schempp, S. Hezel, and C. Simon, Hautarzt. 54, 248 (2003).

    CAS  Google Scholar 

  46. D. Schwarz, P. Kisselev, and I. Roots, Cancer Res. 63, 8062 (2003).

    CAS  Google Scholar 

  47. A. A. Neifakh and M. Ya. Timofeeva, Problems of Regulation in Molecular Biology of Development (Nauka, Moscow, 1978) [in Russian].

    Google Scholar 

  48. S. F. Gilbert, Developmental Biology, in 3 vols. (Palgrave Macmillan, London, 2010; Mir, Moscow, 1994), Vol. 2.

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Authors and Affiliations

  1. Zhirmunsky Institute of Marine Biology, Far East Branch, Russian Academy of Sciences, Vladivostok, Russia

    A. L. Drozdov & I. A. Beleneva

  2. Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russia

    F. D. Lepeshkin, A. A. Krutikova, K. B. Ustinovich, O. I. Pokrovskii & O. O. Parenago

  3. Far East Federal University, Vladivostok, Russia

    A. L. Drozdov

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  1. A. L. Drozdov
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  2. I. A. Beleneva
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  3. F. D. Lepeshkin
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  4. A. A. Krutikova
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  5. K. B. Ustinovich
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  6. O. I. Pokrovskii
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  7. O. O. Parenago
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Correspondence to A. L. Drozdov.

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Original Russian Text © A.L. Drozdov, I.A. Beleneva, F.D. Lepeshkin, A.A. Krutikova, K.B. Ustinovich, O.I. Pokrovskii, O.O. Parenago, 2012, published in Sverkhkriticheskie Flyuidy: Teoriya i Praktika, 2012, Vol. 7, No. 4, pp. 59–71.

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Drozdov, A.L., Beleneva, I.A., Lepeshkin, F.D. et al. The effect of St. John’s wort supercritical extract and hyperforin solution on biological subjects. Russ. J. Phys. Chem. B 7, 854–862 (2013). https://doi.org/10.1134/S1990793113070063

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  • DOI: https://doi.org/10.1134/S1990793113070063

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