Russian Journal of Physical Chemistry B

, Volume 6, Issue 3, pp 404–406 | Cite as

Interaction of RNA molecules: Binding energy and the statistical properties of random sequences

  • O. V. Val’baEmail author
  • S. K. Nechaev
  • M. V. Tamm
Chemical Physics of Biological Processes


The free binding energy of two RNA molecules is determined and some statistical properties such as fluctuation of the mean binding energy between two RNA molecules and the distribution of loop lengths in the structure formed are discussed. An analysis of the dependence of the specific free energy of a complex of two long random RNA molecules on the number c of nucleotide types led us to suggest that the four-letter genetic alphabet used by nature plays a special role.


interaction of RNA sequences statistical properties random walk 


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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  1. 1.Moscow Institute of Physics and TechnologyDolgoprudnyi, Moscow oblastRussia
  2. 2.Semenov Institute of Chemical PhysicsRussian Academy of SciencesMoscowRussia
  3. 3.LPTMSUniversity Paris SudOrsayFrance
  4. 4.Moscow State UniversityMoscowRussia

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