Abstract
Background: Obstructive sleep apnea (OSA) is characterized by recurrent apnea/hypopnea in the upper airways and oxygen desaturation accompanying respiratory events during sleep. Our study aimed to determine serum LECT2 and sclerostin levels in OSA patients. Methods: Patients who applied with the suspicion of OSA in the polysomnography unit of our hospital between June 2022 and April 2023 and who completed the polysomnography test were included in our study. Group 1: apnea-hypopnea index (AHI) < 5/h control group (n = 80), Group 2: OSA patients with AHI ≥ 5/h without comorbidity (n = 80). Results: When comparing the LECT2 and sclerostin levels of the groups, it was observed that there was a statistically significant difference, higher in the OSA group (p < 0.001 for both). When the groups were compared, it was observed that only LECT2 and sclerostin levels were higher in severe OSA patients than in mild OSA patients (p = 0.008, 0.02, respectively). A positive correlation was observed between LECT-2 level and AHI, apnea–hypopnea index during rapid eye movement (REM-AHI), and ODI levels (r = 0.55, p = 0.01, r = 0.42, p = 0.01, r = 0.61, p = 0.01). An inverse correlation was observed between LECT2 and minimum oxygen saturation (r = –0.42, p = 0.01). In the analysis performed with sclerostin level, a positive correlation (r = 0.42, p = 0.01, r = 0.28, p = 0.05, r = 0.53, p = 0.01) was observed with AHI, REM-AHI, and ODI, while an inverse correlation was observed between minimum oxygen saturation. Correlation was observed (r = –0.33, p = 0.01). Conclusion: Serum LECT2 and sclerostin levels in OSA patients can be used to determine the AHI and minimum oxygen saturation levels of individuals and their weight in OSA patients.
Similar content being viewed by others
REFERENCES
Harsch, I.A., Schahin, S.P., Radespiel-Tröger, M., Weintz, O., Jahreiß, H., Fuchs, F.S., Wiest, G.H., Hahn, E.G., Lohmann, T., and Konturek, P.C., Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome, Am. J. Respir. Crit. Care Med., 2004, vol. 169, pp. 156–162.
Blechner, M. and Williamson, A.A., Consequences of obstructive sleep apnea in children, Curr. Probl. Pediatr. Adolesc. Health Care, 2016, vol. 46, pp. 19–26.
Nagal, H., Hamada, T., Uchida, T., Yamagoe, S., and Suzuki, K., Systemic expression of a newly recognized protein, LECT2, in the human body, Pathol. Int., 1998, vol. 48, pp. 882–886.
Lu, X.-J., Chen, J., Yu, C.-H., Shi, Y.-H., He, Y.-Q., Zhang, R.-C., Huang, Z.-A., Lv, J.-N., Zhang, S., and Xu, L., LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor, J. Exp. Med., 2013, vol. 210, pp. 5–13.
Ando, K., Kato, H., Kotani, T., Ozaki, M., Arimura, Y., and Yagi, J., Plasma leukocyte cell-derived chemotaxin 2 is associated with the severity of systemic inflammation in patients with sepsis, Microbiol. Immunol., 2012, vol. 56, pp. 708–718.
Yoo, H.J., Hwang, S.Y., Choi, J.-H., Lee, H.J., Chung, H.S., Seo, J.-A., Kim, S.G., Kim, N.H., Baik, S.H., and Choi, D.S., Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis, PLoS One, 2017, vol. 12, p. e0174717.
Okumura, A., Unoki-Kubota, H., Matsushita, Y., Shiga, T., Moriyoshi, Y., Yamagoe, S., and Kaburagi, Y., Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver, Biosci. Trends, 2013, vol. 7, pp. 276–283.
Galea, G.L., Lanyon, L.E., and Price, J.S., Sclerostin’s role in bone’s adaptive response to mechanical loading, Bone, 2017, vol. 96, pp. 38–44.
Frysz, M., Gergei, I., Scharnagl, H., Smith, G.D., Zheng, J., Lawlor, D.A., Herrmann, M., Maerz, W., and Tobias, J.H., Circulating sclerostin levels are positively related to coronary artery disease severity and related risk factors, J. Bone Miner. Res., 2022, vol. 37, pp. 273–284.
Golledge, J. and Thanigaimani, S., Role of sclerostin in cardiovascular disease, Arterioscler., Thromb., Vasc. Bi-ol., 2022, vol. 42, pp. e187–e202.
De Backer, W., Obstructive sleep apnea/hypopnea syndrome, Panminerva Med., 2013, vol. 55, pp. 191–195.
Javaheri, S., Barbe, F., Campos-Rodriguez, F., Dempsey, J.A., Khayat, R., Javaheri, S., Malhotra, A., Martinez-Garcia, M.A., Mehra, R., and Pack, A.I., Sleep apnea: Types, mechanisms, and clinical cardiovascular consequences, J. Am. Coll. Cardiol., 2017, vol. 69, pp. 841–858.
Floras, J.S., Sleep apnea and cardiovascular disease: An enigmatic risk factor, Circ. Res., 2018, vol. 122, pp. 1741–1764.
Tietjens, J.R., Claman, D., Kezirian, E.J., De Marco, T., Mirzayan, A., Sadroonri, B., Gold-berg, A.N., Long, C., Gerstenfeld, E.P., and Yeghiazarians, Y., Obstructive sleep apnea in cardiovascular disease: A review of the literature and proposed multidisciplinary clinical management strategy, J. Am. Heart Assoc., 2019, vol. 8, p. e010440.
Halpern, R., Iqbal, S.U., Kazis, L.E., Macarios, D., and Badamgarav, E., The association of adherence to osteoporosis therapies with fracture, all-cause medical costs, and all-cause hospitalizations: A retrospective claims analysis of female health plan enrollees with osteoporosis, J. Managed Care Pharm., 2011, vol. 17, pp. 25–39.
Arnett, T.R., Acidosis, hypoxia and bone, Arch. Biochem. Biophys., 2010, vol. 503, pp. 103–109.
Arnett, T.R., Gibbons, D.C., Utting, J.C., Orriss, I.R., Hoebertz, A., Rosendaal, M., and Meghji, S., Hypoxia is a major stimulator of osteoclast formation and bone resorption, J. Cell. Physiol., 2003, vol. 196, pp. 2–8.
Chen, Y.-L., Weng, S.-F., Shen, Y.-C., Chou, C.-W., Yang, C.-Y., Wang, J.-J., and Tien, K.-J., Obstructive sleep apnea and risk of osteoporosis: A population-based cohort study in Taiwan, J. Clin. Endocrinol. Metab., 2014, vol. 99, pp. 2441–2447.
Dang, M.H., Kato, H., Ueshiba, H., Omori-Miyake, M., Yamagoe, S., Ando, K., Imanishi, K.I., Arimura, Y., Haruta, I., and Kotani, T., Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in D-galactosamine-sensitized mice, Clin. Immunol., 2010, vol. 137, pp. 311–321.
Hwang, H.-J., Jung, T.W., Hong, H.C., Seo, J.A., Kim, S.G., Kim, N.H., Choi, K.M., Choi, D.S., Baik, S.H., and Yoo, H.J., LECT2 induces atherosclerotic inflammatory reaction via CD209 receptor-mediated JNK phosphorylation in human endothelial cells, Metabolism, 2015, vol. 64, pp. 1175–1182.
Okumura, A., Saito, T., Otani, I., Kojima, K., Yamada, Y., Ishida-Okawara, A., Nakazato, K., Asano, M., Kanayama, K., and Iwakura, Y., Suppressive role of leukocyte cell–derived chemotaxin 2 in mouse anti–type II collagen antibody–induced arthritis, Arthritis Rheum., 2008, vol. 58, pp. 413–421.
Wang, Q., Xu, F., Chen, J., Xie, Y.-Q., Xu, S.-L., and He, W.-M., Serum leukocyte cell-derived chemotaxin 2 (LECT2) level is associated with osteoporosis, Lab. Med., 2023, vol. 54, pp. 106–111.
Kotake, K., Mitsuboshi, S., Omori, Y., Kawakami, Y., and Kawakami, Y., Evaluation of risk of cardiac or cerebrovascular events in romosozumab users focusing on comorbidities: Analysis of the Japanese Adverse Drug Event Report Database, J. Pharm. Technol., 2023, vol. 39, pp. 23–28.
Tirandi, A., Arboscello, E., Ministrini, S., Liberale, L., Bonaventura, A., Vecchié, A., Bertolotto, M., Giacobbe, D.R., Castellani, L., and Mirabella, M., Early sclerostin assessment in frail elderly patients with sepsis: Insights on short-and long-term mortality prediction, Inter-n. Emerg. Med., 2023, vol. 18, pp. 1509–1519.
Funding
This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
ETHICS APPROVAL AND CONSENT TO PARTICIPATE
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. They were also approved by the Ethics Committee of Ataturk University protocol no: B.30.2.ATA.0.01.00/432 dated June 2, 2022.Each participant in the study provided a voluntary written informed consent after receiving an explanation of the potential risks and benefits, as well as the nature of the upcoming study.
CONFLICT OF INTEREST
The authors of this work declare that they have no conflicts of interest.
Additional information
Publisher’s Note.
Pleiades Publishing remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Buğra Kerget, Çil, G., Afşin, D.E. et al. Evaluation of Serum LECT2 and Sclerostin Levels in Patients Followed up for Obstructive Sleep Apnea. Biochem. Moscow Suppl. Ser. B 17, 157–164 (2023). https://doi.org/10.1134/S1990750823600425
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1990750823600425