Abstract
The authors examined 111 practically healthy individuals (66 women and 45 men aged 46–55 years) living and working in the Spitsbergen archipelago as well as in Murmansk oblast. The comparison group included 118 practically healthy people (59 women and 59 men, 46–55 years old) born and living in Arkhangelsk oblast. The hemogram of peripheral venous blood, the content of lymphocytes with the phenotypes CD3+, CD4+, CD8+, CD10+, CD16+, CD19+, CD23+, CD25+, and CD71+ were studied using indirect immunoperoxidase reaction and flow cytometry; concentrations of brain natriuretic peptide Nt-pro-BNP, endothelin-1, total NO, endogenous NO2, nitrate NO3, cortisol, norepinephrine, adrenaline were studied using enzyme-linked immunosorbent assay. It has been established that individuals living in the Arctic and territories equated to the regions of the Far North have a higher concentration of Nt-pro-BNP in the venous peripheral blood. Elevated blood concentrations of Nt-pro-BNP are associated with higher levels of norepinephrine and cortisol against the background of less pronounced concentrations of adrenaline and endothelin-1 as well as redistribution of lymphocytes and monocytes from the circulating pool to the marginal pool.
REFERENCES
Mareev, V.Yu., Ageev, F.T., Arutyunov, G.P., Koroteev, A.V., and Revishvili, A.Sh., National recommendations of the VNOK and OSSN for the diagnosis and treatment of CHF (third revision), J. Heart Failure, 2009, vol. 10, no. 2, pp. 64–106.
Bazzino, O., Furreni, J.J., Botto, F., De Arenaza, D.P., Bahit, C., and Dadone, J., Relative value of N-terminal probrain natriuretic peptide, TIMI risk score, ACC/AHA prognostic classification and other risk markers in patients with non-ST-elevation acute coronary syndromes, Eur. Heart J., 2004, vol. 25, no. 10, pp. 859–866. https://doi.org/10.1016/j.ehj.2004.03.004
Schrader, E.V., Shakhnovich, R.M., Kaznachee-va, E.I., Bosykh, E.G., Tkachev, G.A., and Ore, M.Ya., Prognostic value of markers of inflammation and NT-pro-BNP in various treatment options for patients with acute coronary syndrome, Cardiol. Bull., 2008, vol. 3, no. 2, pp. 44–53.
Makoeva, M.H., Fedorova, M.M., Avtandilov, A.G., Semitko, S.P., Dolgov, V.V., and Roitman, A.P., Dynamics and prognostic value of cerebral natriuretic peptide and C-reactive protein in acute myocardial infarction depending on treatment tactics, Klin. Lab. D-iagn., 2014, vol. 59, no. 2, pp. 23–26.
Conssens, L.M. and Werb, Z., Inflammatory cells and cancer: Think different, J. Exp. Med., 2001, vol. 193, pp. 23–26. https://doi.org/10.1084/jem.193.6.f23
Di Carlo, E., Forni, G., and Musiant, P., Neutrophyls is the antitumoral immune response, Chem. Immunol. Allergy, 2001, vol. 83, pp. 182–203. https://doi.org/10.1159/000071561
Pretswich, R.J., Errington, F., and Hatfield, P., The immune system is it relevant to cancer development, progression and treatment, Clin. Oncol., 2008, vol. 20, pp. 101–112. https://doi.org/10.1016/j.clon.2007.10.011
Sokolova, I.A., Erythrocyte aggregation, Reg. Krovoobrashch. Mikrotsirk., 2010, vol. 9, no. 4, pp. 4–26.
Stavinskaya, O.A., Repina, V.P., Poletaeva, A.V., and Dobrodeeva, L.K., The effect of histamine on the regulation of immunological reactivity in humans, Vest. Pomor. Univ. Ser. Est. Tochn. Nauki, 2008, no. 2, pp. 35–40.
Repina, V.P., The effect of different concentrations of catecholamines on the functioning of immunocompetent cells, Ekol. Chel., 2008, no. 2, pp. 30–33.
Samodova, A.V., Dobrodeeva, L.K. Shtaborov, V.A., and Pashinskaya, K.O., The effect of reactions of brain natriuretic peptide, irisin, endothelin-1 on the state of the immune system in people working in the Svalbard Archipelago, depending on the length of residence, Vestn. Kol’sk. Nauchn. Tsentra Ross. Akad. Nauk, 2018, vol. 10, no. 3, pp. 87–92.
Kvandal, P., Sheppard, L., Landsverk, S.A., Stefanovska, A., and Kirkeboen, K.A., Impaired cerebrovascular reactivity after acute traumatic brain injuru can detected by wavelet phase coherence analysis of the intracranial and arterial blood pressure signals, J. Clin. Monit. Comput., 2013, vol. 27, no. 4, pp. 375–383. https://doi.org/10.1007/s10877-013-9484-z
Chuyan, E.N., Tribrat, N.S., Ravaeva, M.Yu., and Ananchenko, M.N., Tkanevaya mikrogemodinamika: vliyanie nizkointensivnogo elektromagnitnogo izlucheniya millimetrovogo diapazona (Tissue Microhemodynamics: The Effect of Low-Intensity Electromagnetic Radiation in the Millimeter Range), Simferopol: Arial, 2017.
Negrusz-Kawechka, M., The role of endothelins in human cardiovascular disease, Pol. Merkuriusz Lek., 2001, vol. 11, pp. 444–446.
Samigullin, D., Khaziev, E., Zhilyakov, N., Sudakov, I., Bukharaeva, E., and Nikolsky, E., Calcium transient registration in response to single stimulation and during train of pulses in mouse neuromuscular junction, BioNanoScience, 2017, vol. 7, pp. 162–166. https://doi.org/10.1007/s12668-016-0318-6
Kosharnaya, R.S., Belaya, Zh.E., Zuraeva, Z.T., Michurova, M.S., and Kalashnikov, V.Yu., Dynamics of NT-proBNP and ST2 levels as markers of heart failure in patients with endogenous hypercorticism, Ter. Arkh., 2022, vol. 94, no. 12, pp. 1387–1393. https://doi.org/10.26442/00403660.2022.12.201995
Lacroix, A., Feelders, R.A., Stratakis, C.A., and Nieman, L.K., Cushing’s syndrome, Lancet, 2015, vol. 386, no. 9996, pp. 913–927. https://doi.org/:10.1016/S0140-6736(14)61375-1
Kamenický, P., Redheuil, A., Roux, C., et al., Cardiac structure and function in Cushing’s syndrome: A cardiac magnetic resonance imaging study, J. Clin. Endocrinol. Metab., 2014, vol. 99, no. 11, pp. E2144–E2153. https://doi.org/10.1210/jc.2014-1783
Di Dalmazi, G. and Pasquali, R. Adrenal adenomas, subclinical hypercortisolism, and cardiovascular outcomes, Curr. Opin. Endocrinol., Diabetes Obes., 2015, vol. 22, no. 3, pp. 163–168. https://doi.org/10.1097/MED.0000000000000153
Wright, D.G., Fauci, A.S., Dale, D.C., and Wolff, S.M., Correction of human cyclic neutropenia with prednisolone, N. Engl. J. Med., 1978, vol. 298, no. 6, pp. 295–300. https://doi.org/10.1056/NEJM197802092980602
Tipisova, E.V., Reactivity and compensatory reactions of the endocrine system in the male population of the European North, Doctoral (Biol.) Dissertation, Arkhangelsk: Pomor. Gos. Univ., 2007.
Funding
The work was carried out within the framework of the fundamental scientific research program Mechanisms of Interaction of Systemic and Local Immune Reactions in Persons Working in the Arctic (Barentsburg, Spitsbergen; Revda and Lovozero, Murmansk oblast) (state registration no. 122011800217-9) of the Laverov Federal Research Center for Integrated Study of the Arctic, Ural Branch, Russian Academy of Sciences, Arkhangelsk.
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All examinations were carried out with the written consent of volunteers and in accordance with the requirements of the World Medical Association’s Declaration of Helsinki on Ethical Principles for Medical Research (2013). The studies were approved by the Biomedical Ethics Commission at the Laverov Federal Research Center for Integrated Study of the Arctic, Ural Branch, Russian Academy of Sciences (protocol no. 8 of March 30, 2022).
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Samodova, A.V., Dobrodeeva, L.K. The Influence of Increased Concentrations of Brain Natriuretic Peptide on the Level of Hemodynamic Reactions in Individuals Living and Working in the European North and the Arctic of the Russian Federation. Biochem. Moscow Suppl. Ser. B 17, 183–188 (2023). https://doi.org/10.1134/S1990750823600322
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DOI: https://doi.org/10.1134/S1990750823600322