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Selenium Compounds in Redox Regulation of Inflammation and Apoptosis

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Abstract

Monocytes and macrophages play a key role in the development of inflammation induced by lipopolysaccharides (LPS), absorbed from the intestine: these cells form reactive oxygen species (ROS) and cytokines, thus initiating the development of oxidative stress, inflammation and/or apoptosis in all types of tissues. In the cells LPS induce an “internal” TLR4-mediated MAP-kinase inflammatory signaling pathway and cytokines through the superfamily of tumor necrosis factor receptor (TNFR) and the “death domain” (DD) initiate an “external” caspase apoptosis cascade or necrosis activation causing necroptosis. Many of the proteins involved in intracellular signaling cascades (MYD88, ASK1, IKKα/β, NF-κB, AP-1) are redox-sensitive and their activity is regulated by antioxidants thioredoxin, glutaredoxin, nitroredoxin, and glutathione. Oxidation of these signaling proteins induced by ROS promotes development of inflammation and apoptosis, and antioxidants, have an opposite effect: they stabilize the signaling cascades, prevent the vicious circle of oxidative stress, accompanied by inflammation and apoptosis. Reduction of non-enzymatic antioxidants (thioredoxin, glutaredoxin, nitroredoxin, glutathione) requires antioxidant (AO) enzymes thioredoxin reductase (TRXR), glutaredoxin reductase (GLRXR), glutathione reductase (GR), while the AO enzymes SOD, catalase, GPX are needed for ROS degradation. The key AO enzymes (TRXR and GPX) are selenium-dependent and therefore selenium deficiency leads to a decrease in the antioxidant defense, development of oxidative stress, inflammation, and/or apoptosis in various cell types. The Nrf2-Keap1 signaling pathway activated by selenium deficiency and/or oxidative stress is necessary to restore redox homeostasis in the cell. Selenium deficiency also influences expression of some genes. Consequently, growth and proliferation of cells, their movement, development, death, and survival, as well as interaction between cells, redox regulation of intracellular signaling cascades of inflammation and apoptosis, depend on the selenium status of the body. Prophylactic administration of selenium-containing preparations (natural and synthetic (organic and inorganic)) is able to normalize activity of AO enzymes and the general status of the body. Organic selenium compounds have a high bioavailability and, depending on their concentration, can act both as selenium donors preventing selenium deficiency and as antitumor drugs due to their toxicity and involvement in regulation of signaling pathways of apoptosis. Known selenorganic compounds diphenyldiselenide and ethaselen share similarity with the Russian organoselenium compound, diacetophenonylselenide (DAPS-25), which serves as a source of bioavailable selenium, exhibits a wide range of biological activity, including antioxidant activity, that governs cell redox balance and regulates inflammation and apoptosis.

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  1. Razumovsky Saratov State Medical University, ul. B. Kazachya 112, 410012, Saratov, Russia

    N. Y. Rusetskaya, I. V. Fedotov, V. A. Koftina & V. B. Borodulin

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Translated by A. Medvedev

   Abbreviations used: AP-1—Activator protein-1; ARE—Antioxidant-responsive element; ASK1—Apoptosis signal regulated kinase 1; BAA—biologically active additives; COX—Cyclooxygenase; Cul3—Cullin-3-containing ubiquitin ligase complex E3; DAPS-25—Diacetophenonylidene; DAMP—Damage-associated molecular pattern, DD—Death domen; GCL—Glutamate-cysteine ligase; GPX—Glutathione peroxidase; GR—Glutathione reductase; GST—Glutathione S-transferase; GRX1—Glutaredoxin 1; GLRXR—Glutaredoxin reductase; HMOX—Heme oxygenase 1; IL—Interleukin; Keap1—Kelch-like ECH-associated protein-1; LOX—Lipoxygenase; LPS—Lipopolysaccharides; MAPK—Mitogen activated protein kinase (MAP kinase); MCh ETC—Mitochondrial electron transport chain; MYD88—Myeloid differentiation factor; NF-κB—Nuclear factor-κB, NOS—NO-synthase, NOX—NADP-oxidase; NQO1—NAD(P)H quinone oxidoreductase 1; NP— Nanoparticles; Nrf2—Nuclear factor erythroid-2-related factor 2; NRX—Nucleoredoxin; PAMP—Pathogen-associated molecular pattern; ROS—reactive oxygen species; SOD—Superoxide dismutase; TLR—Toll-like receptor; TNF-α—Tumor necrosis factor-α; TNFR—Tumor necrosis factor receptor; Trnau1ap—tRNA-selenocysteine 1-associated protein; TRX—Thioredoxin, Thioredoxin; TRXR—Thioredoxin reductase.

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Rusetskaya, N.Y., Fedotov, I.V., Koftina, V.A. et al. Selenium Compounds in Redox Regulation of Inflammation and Apoptosis. Biochem. Moscow Suppl. Ser. B 13, 277–292 (2019). https://doi.org/10.1134/S1990750819040085

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