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Pharmacological Targets for Correction of Dyslipidemias. Opportunities and Prospects of Therapeutic Use

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Abstract

The review summarizes literature data on existing pharmacological agents and novel drug preparations developed for correction of dyslipidemias and molecular mechanisms of their action. Much attention is paid to analysis of experimental and clinical studies aimed at identification of new pharmacological targets for correction of dyslipidemias and characterization of approaches increasing high density lipoproteins functionality. The implementation of alternative pharmacological agents with new alternative mechanisms of action may improve the effectiveness of traditional treatment in the future.

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Abbreviations

ABCA1:

ATP-binding cassette transporter A1

ABCG1:

ATP-binding cassette transporter G1

ABCG5:

ATP-binding cassette transporter G5

ABCG8:

ATP-binding cassette transporter G8

ACS:

acute coronary syndrome

AP2:

Adaptor protein 2

Apo A-1:

apolipoprotein A-1

Apo B:

apolipoprotein B

BD2:

Bromodomain 2

BET:

Bromodomain and extra-terminal domain

B-PAV:

Baseline percent atheroma volume

CETP:

Cholesterol ester transfer protein

CEC:

Cholesterol efflux capacity

Chol:

cholesterol

CholE:

cholesterol esters

CVDs:

cardiovascular diseases

DGAT2:

Diacylglycerol acyltransferase 2

FA:

fatty acids

FAMP:

Fukuoka University ApoA-I Mimetic Peptide

FXR:

Farnesoid X receptor)

GIT:

gastrointestinal tract

HCA:

Hyocholic acid)

HDCA:

Hyodeoxycholic acid

HDL:

high density lipoproteins

HDL-C:

high-density lipoprotein cholesterol

HDLR:

high density lipoprotein receptors

HMG-CoA reductase:

β-hydroxy-β-methyl glutarylcoenzyme A reductase

LDL:

low density lipoproteins

LDLR:

low density lipoprotein receptors

LDL-C:

low-density lipoprotein cholesterol

LPA:

lysophosphatidic acid

LXR:

Liver X receptors

MACE:

Major Adverse Cardiac Events

MHC II:

Major histocompatibility complex class II

NOS:

Nitric oxide synthase

NPC1L1:

Niemann-Pick C1-like 1 protein

PCh:

phosphatidylcholine

PCSK9:

Proprotein convertase subtilisin/kexin type 9

PL:

phospholipids

PPAR:

Peroxisome proliferator-activated receptors

RCT:

reverse cholesterol transport

SRB1:

Scavenger receptor class B member 1

SREBR-2:

Sterol regulatory element- binding protein 2

TGR5:

Transmembrane G protein coupled bile acid receptor

TG:

triglycerides

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  1. Institute of Biomedical Chemistry (IBMC), ul. Pogodinskaya 10, Moscow, 119121, Russia

    V. A. Kudinov, T. S. Zakharova, T. I. Torkhovskaya, O. M. Ipatova & A. I. Archakov

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  1. V. A. Kudinov
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  2. T. S. Zakharova
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Original Russian Text © V.A. Kudinov, T.S. Zakharova, T.I. Torkhovskaya, O.M. Ipatova, A.I. Archakov, 2018, published in Biomeditsinskaya Khimiya.

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Kudinov, V.A., Zakharova, T.S., Torkhovskaya, T.I. et al. Pharmacological Targets for Correction of Dyslipidemias. Opportunities and Prospects of Therapeutic Use. Biochem. Moscow Suppl. Ser. B 12, 96–113 (2018). https://doi.org/10.1134/S1990750818020075

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