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Molecular organization of the microsomal oxidative system: a new connotation for an old term

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Abstract

The central role that cytochromes P450 play in the metabolism of drugs and other xenobiotics makes these enzymes a major subject for studies of drug disposition, adverse drug effects and drug-drug interactions. Despite tremendous success in elucidating structures and mechanisms of cytochrome P450 function, the concept of the drug-metabolizing ensemble as a functionally integrated system remains undeveloped. However, eukaryotic cells typically possess a multitude of different cytochromes P450 that are co-localized in the membrane of endoplasmic reticulum (ER); they interact with each other through the formation of dynamic heteromeric complexes (mixed oligomers). There has been growing appreciation of the importance of developing an approach to study the ensemble of cytochromes P450 as an integral system inspired growing interest of researchers to the principles of molecular organization of the microsomal monooxygenase system. Academician Archakov and his colleagues made important contributions to this field during the initial period of studies. Subsequent exploration of the molecular organization of the microsomal monooxygenase system as an integral multienzyme and multifunctional system have had an essential impact on our understanding of the key factors that determine the changes in human drug metabolism and other cytochrome P450-related functions in development and aging, as well as under the influence of various pathologies and environmental factors.

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References

  1. Nelson, D.R., Kamataki, T., Waxman, D.J., Guengerich, F.P., Estabrook, R.W., Feyereisen, R., Gonzalez, F.J., Coon, M.J., Gunsalus, I.C., Gotoh, O., Okuda, K., and Nebert, D.W., DNA and Cell Biology, 1993, vol. 12, pp. 1.51.

    Article  CAS  Google Scholar 

  2. Kahn, R.A. and Durst, F., in Evolution of Metabolic Pathways, Romeo, J.T., Ibrahim, R., Varin, L., and DeLuca, V., Eds., 2000, pp. 151–189.

  3. Nakahara, K., Tanimoto, T., Hatano, K., Usuda, K., and Shoun, H., J. Biol. Chem., 1993, vol. 268, pp. 8350–8355.

    CAS  Google Scholar 

  4. Sezutsu, H., Le Goff, G., and Feyereisen, R., Philosophical Transactions of the Royal Society B-Biological Sciences, 2013, vol. 368, 20120428. doi 10.1098/rstb.2012.0428

    Article  Google Scholar 

  5. Lewis, D.F. and Sheridan, G., Scientific World J., 2001, vol. 1, pp. 151–167.

    Article  CAS  Google Scholar 

  6. Lee, D.S., Nioche, P., Hamberg, M., and Raman, C.S., Nature, 2008, vol. 455, pp. 363–368.

    Article  CAS  Google Scholar 

  7. Nebert, D.W. and Feyereisen, R., in Cytochrome P450: Biochemistry, Biophysics and Molecular Biology, 8th Int. Conf., Lechner, M.C., Ed., Paris: John Libbey Eurotext, 1994, pp. 3–13.

  8. Omura, T., Biotechnol. Appl. Biochem., 2013, vol. 60, pp. 4–8.

    Article  CAS  Google Scholar 

  9. Graham, S.E. and Peterson, J.A., Arch. Biochem. Biophys., 1999, vol. 369, pp. 24–29.

    Article  CAS  Google Scholar 

  10. Ingelman-Sundberg, M., Toxicol. Appl. Pharmacol., 2005, vol. 207, pp. 52–56.

    Article  Google Scholar 

  11. Gomes, A.M., Winter, S., Klein, K., Turpeinen, M., Schaeffeler, E., Schwab, M., and Zanger, U.M., Pharmacogenomics, 2009, vol. 10, pp. 579–599.

    Article  CAS  Google Scholar 

  12. Yang, C.S., Life Sci., 1977, vol. 21, pp. 1047–1057.

    Article  CAS  Google Scholar 

  13. Franklin, M.R. and Estabhrook, R.W., Arch. Biochem. Biophys., 1971, vol. 143, pp. 318–329.

    Article  CAS  Google Scholar 

  14. Stier, A. and Sackmann, E., Biochim. Biophys. Acta, 1973, vol. 311, pp. 400–408.

    Article  CAS  Google Scholar 

  15. Stier, A., Biochem. Pharmacol., 1976, vol. 25, pp. 109–113.

    Article  CAS  Google Scholar 

  16. Peterson, J.A., Ebel, R.E., O’keeffe, D.H., Matsubara, T., and Estabrook, R.W., J. Biol. Chem., 1976, vol. 251, pp. 4010–4016.

    CAS  Google Scholar 

  17. Archakov, A.I., Borodin, E.A., Davydov, D.R., Karyakin, A.I., and Borovyagin, V.L., Biochem. Biophys. Res. Commun., 1982, vol. 109, pp. 832–840.

    Article  CAS  Google Scholar 

  18. Kaminsky, L.S. and Guengerich, F.P., Eur. J. Biochem., 1985, vol. 149, pp. 479–489.

    Article  CAS  Google Scholar 

  19. Chen, G.F., Ronis, M.J., Ingelman-Sundberg, M., and Badger, T.M., Xenobiotica, 1999, vol. 29, pp. 437–451.

    Article  CAS  Google Scholar 

  20. Cawley, G.F., Batie, C.J., and Backes, W.L., Biochemistry, 1995, vol. 34, pp. 1244–1247.

    Article  CAS  Google Scholar 

  21. Yamazaki, H., Inoue, K., Mimura, M., Oda, Y., Guengerich, F.P., and Shimada, T., Biochem. Pharmacol., 1996, vol. 51, pp. 313–319.

    Article  CAS  Google Scholar 

  22. Tan, Y., Patten, C.J., Smith, T., and Yang, C.S., Arch. Biochem. Biophys., 1997, vol. 342, pp. 82–91.

    Article  CAS  Google Scholar 

  23. Davydov, D.R., Petushkova, N.A., Bobrovnikova, E.V., Knyushko, T.V., and Dansette, P., Adv. Exp. Med. Biol., 2001, vol. 500, pp. 335–338.

    Article  CAS  Google Scholar 

  24. Davydov, D.R., Expert Opin. Drug Metab. Toxicol., 2011, vol. 7, pp. 543–558.

    Article  CAS  Google Scholar 

  25. Reed, J.R. and Backes, W.L., Pharm. Ther., 2012, vol. 133, pp. 299–310.

    Article  CAS  Google Scholar 

  26. Tralau, T. and Luch, A., Expert Opin. Drug Metab. Toxicol., 2013, vol. 9, pp. 1541–1554.

    Article  CAS  Google Scholar 

  27. Guengerich, F.P. and Holladay, L.A., Biochemistry, 1979, vol. 18, pp. 5442–5449.

    Article  CAS  Google Scholar 

  28. French, J.S., Guengerich, F.P., and Coon, M.J., J. Biol. Chem., 1980, vol. 255, pp. 4112–4119.

    CAS  Google Scholar 

  29. Wendel, I., Behlke, J., and Janig, G.R., Biomed. Biochim. Acta, 1983, vol. 42, pp. 623–631.

    CAS  Google Scholar 

  30. Dean, W.L. and Gray, R.D., Biochem. Biophys. Res. Commun., 1982, vol. 107, pp. 265–271.

    Article  CAS  Google Scholar 

  31. Tsuprun, V.L., Myasoedova, K.N., Berndt, P., Sograf, O.N., Orlova, E.V., Chernyak, V.Ya., Archakov, A.I., and Skulachev, V.P., FEBS Lett., 1986, vol. 205, pp. 35–40.

    Article  CAS  Google Scholar 

  32. Davydov, D.R., Fernando, H., Baas, B.J., Sligar, S.G., and Halpert, J.R., Biochemistry, 2005, vol. 44, pp. 13902–13913.

    Article  CAS  Google Scholar 

  33. Fernando, H., Davydov, D.R., Chin, C.C., and Halpert, J.R., Arch. Biochem. Biophys., 2007, vol. 460, pp. 129–140.

    Article  CAS  Google Scholar 

  34. Pernecky, S.J., Olken, N.M., Bestervelt, L.L., and Coon, M.J., Arch. Biochem. Biophys., 1995, vol. 318, pp. 446–456.

    Article  CAS  Google Scholar 

  35. Scott, E.E., Spatzenegger, M., and Halpert, J.R., Arch. Biochem. Biophys., 2001, vol. 395, pp. 57–68.

    Article  CAS  Google Scholar 

  36. von Wachenfeldt, C., Richardson, T.H., Cosme, J., and Johnson, E.F., Arch. Biochem. Biophys., 1997, vol. 339, pp. 107–114.

    Article  CAS  Google Scholar 

  37. Gillam, E.M.J., Chem. Res. Toxicol., 2008, vol. 21, pp. 220–231.

    Article  Google Scholar 

  38. Shukla, A., Huang, W., Depaz, I.M., and Gillam, E.M.J., Xenobiotica, 2009, vol. 39, pp. 495–507.

    Article  CAS  Google Scholar 

  39. Kempf, A.C., Zanger, U.M., and Meyer, U.A., Arch. Biochem. Biophys., 1995, vol. 321, pp. 277–288.

    Article  CAS  Google Scholar 

  40. Dong, M.S., Yamazaki, H., Guo, Z., and Guengerich, F.P., Arch. Biochem. Biophys., 1996, vol. 327, pp. 11–19.

    Article  CAS  Google Scholar 

  41. Cosme, J. and Johnson, E.F., J. Biol. Chem., 2000, vol. 275, pp. 2545–2553.

    Article  CAS  Google Scholar 

  42. Cosme, J. and Johnson, E.F., Methods Enzymol., 2002, vol. 357, pp. 116–120.

    Article  CAS  Google Scholar 

  43. Richter, C., Winterhalter, K.H., and Cherry, R.J., FEBS Letts., 1979, vol. 102, pp. 151–154.

    Article  CAS  Google Scholar 

  44. Mcintosh, P.R., Kawato, S., Freedman, R.B., and Cherry, R.J., FEBS Letts., 1980, vol. 122, pp. 54–58.

    Article  CAS  Google Scholar 

  45. Gut, J., Richter, C., Cherry, R.J., Winterhalter, K.H., and Kawato, S., J. Biol. Chem., 1983, vol. 258, pp. 8588–8594.

    CAS  Google Scholar 

  46. Greinert, R., Finch, S.A., and Stier, A., Xenobiotica, 1982, vol. 12, pp. 717–726.

    Article  CAS  Google Scholar 

  47. Hildebrandt, P., Garda, H., Stier, A., Bachmanova, G.I., Kanaeva, I.P., and Archakov, A.I., Eur. J. Biochem., 1989, vol. 186, pp. 383–388.

    Article  CAS  Google Scholar 

  48. Iwase, T., Sakaki, T., Yabusaki, Y., Ohkawa, H., Ohta, Y., and Kawato, S., Biochemistry, 1991, vol. 30, pp. 8347–8351.

    Article  CAS  Google Scholar 

  49. Schwarz, D., Pirrwitz, J., and Ruckpaul, K., Arch. Biochem. Biophys., 1982, vol. 216, pp. 322–328.

    Article  CAS  Google Scholar 

  50. Schwarz, D., Pirrwitz, J., Meyer, H.W., Coon, M.J., and Ruckpaul, K., Biochem. Biophys. Res. Commun., 1990, vol. 171, pp. 175–181.

    Article  CAS  Google Scholar 

  51. Alston, K., Robinson, R.C., Park, S.S., Gelboin, H.V., and Friedman, F.K., J. Biol. Chem., 1991, vol. 266, pp. 735–739.

    CAS  Google Scholar 

  52. Myasoedova, K.N. and Magretova, N.N., Biosci. Rep., 2001, vol. 21, pp. 63–72.

    Article  CAS  Google Scholar 

  53. Reed, J.R., Eyer, M., and Backes, W.L., J. Biol. Chem., 2010, vol. 285, pp. 8942–8952.

    Article  CAS  Google Scholar 

  54. Szczesna-Skorupa, E., Mallah, B., and Kemper, B., J. Biol. Chem., 2003, vol. 278, pp. 31269–31276.

    Article  CAS  Google Scholar 

  55. Praporski, S., Ng, S.M., Nguyen, A.D., Corbin, C.J., Mechler, A., Zheng, J., Conley, A.J., and Martin, L.L., J. Biol. Chem., 2009, vol. 284, pp. 33224–33232.

    Article  CAS  Google Scholar 

  56. Ozalp, C., Szczesna-Skorupa, E., and Kemper, B., Drug Metab. Disp., 2005, vol. 33, pp. 1382–1390.

    Article  CAS  Google Scholar 

  57. Reed, J.R., Connick, J.P., Cheng, D.M., Cawley, G.F., and Backes, W.L., Biochem. J., 2012, vol. 446, pp. 489–497.

    Article  CAS  Google Scholar 

  58. Kawato, S., Gut, J., Cherry, R.J., Winterhalter, K.H., and Richter, C., J. Biol. Chem., 1982, vol. 257, pp. 7023–7029.

    CAS  Google Scholar 

  59. Myasoedova, K.N. and Berndt, P., FEBS Lett., 1990, vol. 275, pp. 235–238.

    Article  CAS  Google Scholar 

  60. Hu, G., Johnson, E.F., and Kemper, B., Drug Metab. Dispos., 2010, vol. 38, pp. 1976–1983.

    Article  CAS  Google Scholar 

  61. Davydov, D.R., Sineva, E.V., Sistla, S., Davydova, N.Y., Frank, D.J., Sligar, S.G., and Halpert, J.R., Biochim. Biophys. Acta, 2010, vol. 1797, pp. 378–390.

    Article  CAS  Google Scholar 

  62. Davydov, D.R., Davydova, N.Y., Sineva, E.V., Kufareva, I., and Halpert, J.R., Biochem. J., 2013, vol. 453, pp. 219–230.

    Article  CAS  Google Scholar 

  63. Yamazaki, H., Gillam, E.M., Dong, M.S., Johnson, W.W., Guengerich, F.P., and Shimada, T., Arch. Biochem. Biophys., 1997, vol. 342, pp. 329–337.

    Article  CAS  Google Scholar 

  64. Hazai, E. and Kupfer, D., Drug Metab. Disp., 2005, vol. 33, pp. 157–164.

    Article  CAS  Google Scholar 

  65. Subramanian, M., Low, M., Locuson, C.W., and Tracy, T.S., Drug Metab. Disp., 2009, vol. 37, pp. 1682–1689.

    Article  CAS  Google Scholar 

  66. Subramanian, M., Tam, H., Zheng, H., and Tracy, T.S., Drug Metab. Disp., 2010, vol. 38, pp. 1003–1009.

    Article  CAS  Google Scholar 

  67. Backes, W.L., Batie, C.J., and Cawley, G.F., Biochemistry, 1998, vol. 37, pp. 12852–12859.

    Article  CAS  Google Scholar 

  68. Cawley, G.F., Zhang, S.X., Kelley, R.W., and Backes, W.L., Drug Metab. Disp., 2001, vol. 29, pp. 1529–1534.

    CAS  Google Scholar 

  69. Davydov, D.R., Petushkova, N.A., Archakov, A.I., and Hui Bon Hoa, G., Biochem. Biophys. Res. Commun., 2000, vol. 276, pp. 1005–1012.

    Article  CAS  Google Scholar 

  70. Kelley, W.K., Reed, J.R., and Backes, W.L., Biochemistry, 2005, vol. 44, pp. 2632–2641.

    Article  CAS  Google Scholar 

  71. Kelley, R.W., Cheng, D.M., and Backes, W.L., Biochemistry, 2006, vol. 45, pp. 15807–15816.

    Article  CAS  Google Scholar 

  72. Backes, W.L. and Kelley, R.W., Pharm. Ther., 2003, vol. 98, pp. 221–233.

    Article  CAS  Google Scholar 

  73. Kanaeva, I.P., Dedinskii, I.R., Skotselyas, E.D., Krainev, A.G., Guleva, I.V., Sevryukova, I.F., Koen, Y.M., Kuznetsova, G.P., Bachmanova, G.I., and Archakov, A.I., Arch. Biochem. Biophys., 1992, vol. 298, pp. 395–402.

    Article  CAS  Google Scholar 

  74. Davydov, D.R., Davydova, N.Y., Sineva, E.V., and Halpert, J.R., J. Biol. Chem., 2015, vol. 453, pp. 219–230.

    Google Scholar 

  75. Watanabe, J., Asaka, Y., Kanai, K., and Kanamura, S., J. Histochem. Cytochem., 1992, vol. 40, pp. 353–357.

    Article  CAS  Google Scholar 

  76. Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., and Jhoti, H., Science, 2004, vol. 305, pp. 683–686.

    Article  CAS  Google Scholar 

  77. Green, N.S., Reisler, E., and Houk, K.N., Protein Sci., 2001, vol. 10, pp. 1293–1304.

    Article  CAS  Google Scholar 

  78. Davydov, D.R. and Halpert, J.R., Expert Opin. Drug Metab. Toxicol., 2008,vol. 4, pp. 1523–1535.

    Article  CAS  Google Scholar 

  79. Davydov, D.R., Knyushko, T.V., and Hui Bon Hoa, G., Biochem. Biophys. Res. Commun., 1992, vol. 188, pp. 216–221.

    Article  CAS  Google Scholar 

  80. Davydov, D.R., Deprez, E., Hui Bon Hoa, G., Knyushko, T.V., Kuznetsova, G.P., Koen, Y.M., and Archakov, A.I., Arch. Biochem. Biophys., 1995, vol. 320, pp. 330–344.

    Article  CAS  Google Scholar 

  81. Davydov, D.R. and Hui Bon Hoa, G., in High Pressure Research in the Biosciences and Niotechnology, Heremans, K., Ed., Leuven: Leuven University Press, 1997, pp. 111–114.

  82. Davydov, D.R., Baas, B.J., Sligar, S.G., and Halpert, J.R., Biochemistry, 2007, vol. 46, pp. 7852–7864.

    Article  CAS  Google Scholar 

  83. Davydov, D.R., Halpert, J.R., Renaud, J.P., and Hui Bon Hoa, G., Biochem. Biophys. Res. Commun., 2003, vol. 312, pp. 121–130.

    Article  CAS  Google Scholar 

  84. Anzenbacherova, E., Hudecek, J., Murgida, D., Hildebrandt, P., Marchal, S., Lange, R., and Anzenbacher, P., Biochem. Biophys. Res. Commun., 2005, vol. 338, pp. 477–482.

    Article  CAS  Google Scholar 

  85. Bancel, F., Bec, N., Ebel, C., and Lange, R., Eur. J. Biochem., 1997, vol. 250, pp. 276–285.

    Article  CAS  Google Scholar 

  86. Backes, W.L., Tamburini, P.P., Jansson, I., Gibson, G.G., Sligar, S.G., and Schenkman, J.B., Biochemistry, 1985, vol. 24, pp. 5130–5136.

    Article  CAS  Google Scholar 

  87. Karyakin, A.V. and Davydov, D.R., Vestnik Akad. Med. Nauk SSSR, 1988, no. 1, pp. 53–62.

    Google Scholar 

  88. Fernando, H., Halpert, J.R., and Davydov, D.R., Arch. Biochem. Biophys., 2008, vol. 471, pp. 20–31.

    Article  CAS  Google Scholar 

  89. Tsong, T.Y. and Yang, C.S., Proc. Natl. Acad. Sci. USA, 1978, vol. 75, pp. 5955–5959.

    Article  CAS  Google Scholar 

  90. Fisher, M.T. and Sligar, S.G., Biochemistry, 1987, vol. 26, pp. 4797–4803.

    Article  CAS  Google Scholar 

  91. Brenner, S., Hay, S., Girvan, H.M., Munro, A.W., and Scrutton, N.S., J. Phys. Chem. B., 2007, vol. 111, pp. 7879–7886.

    Article  CAS  Google Scholar 

  92. Ziegler, M., Blanck, J., and Ruckpaul, K., FEBS Lett., 1982, vol. 150, pp. 219–222.

    Article  CAS  Google Scholar 

  93. Sineva, E.V., Rumfeldt, J.A.O., Halpert, J.R., and Davydov, D.R., PLoS One, 2013, vol. 8, e83898.

  94. Zhukov, A.A. and Archakov, A.I., Biokhimiya, 1985, vol. 50, pp. 1939–1952.

    CAS  Google Scholar 

  95. Gruenke, L.D.K., Cadieu, M., and Waskell, L., J. Biol. Chem., 1995, vol. 270, pp. 24707–24718.

    Article  CAS  Google Scholar 

  96. Perret, A. and Pompon, D., Biochemistry, 1998, vol. 37, pp. 11412–11424.

    Article  CAS  Google Scholar 

  97. Gorsky, L.D., Koop, D.R., and Coon, M.J., J. Biol. Chem., 1984,vol. 259, pp. 6812–6817.

    CAS  Google Scholar 

  98. Bondy, S.C. and Naderi, S., Biochem. Pharmacol., 1994, vol. 48, pp. 155–159.

    Article  CAS  Google Scholar 

  99. Zangar, R.C., Davydov, D.R., and Verma, S., Toxicol. Appl. Pharm., 2004, vol. 199, pp. 316–331.

    Article  CAS  Google Scholar 

  100. Shimamoto, N., Yakugaku Zasshi-J. Pharm. Soc. Japan, 2013, vol. 133, pp. 435–450.

    Article  CAS  Google Scholar 

  101. Bae, Y.S., Oh, H., Rhee, S.G., and Do Yoo, Y., Molecules and Cells, 2011, vol. 32, pp. 491–509.

    Article  CAS  Google Scholar 

  102. Circu, M.L. and Aw, T.Y., Free Rad. Biol. Med., 2010, vol. 48, pp. 749–762.

    Article  CAS  Google Scholar 

  103. Davydov, D.R., Trends Biochem. Sci., 2001, vol. 26, pp. 155–160.

    Article  CAS  Google Scholar 

  104. Kufareva, I., Ilatovskiy, A.V., and Abagyan, R., Nucl. Acids Res., 2012, vol. 40, pp. D535–D540.

    Article  CAS  Google Scholar 

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  1. Institute of Biomedical Chemistry, ul. Pogodinskaya 10, Moscow, 119121, Russia

    D. R. Davydov

  2. Department of Chemistry, Washington State University, Pullman, WA, 99164-4630, USA

    D. R. Davydov

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Original Russian Text © D.R. Davydov, 2016, published in Biomeditsinskaya Khimiya.

Invited review to commemorate 60th anniversary of this journal and 70th anniversary of Institute of Biomedical Chemistry.

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Davydov, D.R. Molecular organization of the microsomal oxidative system: a new connotation for an old term. Biochem. Moscow Suppl. Ser. B 10, 10–21 (2016). https://doi.org/10.1134/S1990750816010042

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