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Oxidative stress in the alcoholic liver disease

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Abstract

Parameters reflecting oxidative stress (OS) have been studied in 37 patients with alcoholic liver disease (ALD) during admission to the hospital and 2 weeks after the beginning of therapy. The patients were divided into 3 groups: alcoholic hepatitis (AH), alcoholic cirrhosis with hepatic insufficiency (the group C by the Child-Paquet scale) and terminal stage patients (subsequently died). All patients were characterized by a significant increase in plasma products of lipid peroxidation (conjugated diene and malondialdehyde) and a decrease of the ceruloplasmin level. The coefficient C OS significantly exceeded normal values both on admission and after the 2-week course of traditional therapy. This suggests an important role of the OS with ALD.

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology of Russian Academy of Medical Sciences, Moscow, Russia

    L. F. Panchenko

  2. National Scientific Center of Drug Addiction, M. Mogiltsevskii per. 3, Moscow, 119002, Russia

    B. V. Davydov, N. N. Terebilina & V. Yu. Baronets

  3. Russian University of People’s Friendship, Moscow, Russia

    A. S. Zhuravleva

Authors
  1. L. F. Panchenko
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  2. B. V. Davydov
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  3. N. N. Terebilina
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  4. V. Yu. Baronets
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  5. A. S. Zhuravleva
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Correspondence to B. V. Davydov.

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Original Russian Text © L.F. Panchenko, B.V. Davydov, N.N. Terebilina, V.Yu. Baronets, A.S. Zhuravleva, 2014, published in Biomeditsinskaya Khimiya.

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Panchenko, L.F., Davydov, B.V., Terebilina, N.N. et al. Oxidative stress in the alcoholic liver disease. Biochem. Moscow Suppl. Ser. B 8, 73–76 (2014). https://doi.org/10.1134/S1990750814010120

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  • DOI: https://doi.org/10.1134/S1990750814010120

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