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Peptidase activity of the fetoplacental complex in the norm and pathology

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Abstract

The activity of angiotensin converting enzyme (ACE), carboxypeptidase N (CPN), and leucine aminopeptidase (LAP) has been investigated in the fetoplacental complex (FPC) in norm and fetoplacental insufficiency (FPI). ACE and LAP activities were significantly higher in the placental tissue than in maternal serum and umbilical vein serum. CPN activity was significantly lower in umbilical vein serum as compared to that of women in childbirth. Probably, the studied enzymes are involved in formation of reduced vascular sensitivity of FPC during physiological pregnancy. In cases of placental insufficiency a significant increase of LAP activity was found in the placental tissue and umbilical vein serum. In addition, the pathological course of pregnancy caused a significant increase of CPN activity in serum of pregnant women in comparison to the norm. The obtained data suggest that during FPI proteolytic enzymes participate in the formation of compensatory-adaptive reactions in the FPC. Results of this study are interesting in the context of development of methods for prevention and correction of metabolic disorders in pathologies of pregnancy.

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Authors and Affiliations

  1. Penza State University, ul. Krasnaya 40, Penza, Russia

    O. P. Petrushova & N. I. Mikulyak

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  1. O. P. Petrushova
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  2. N. I. Mikulyak
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Correspondence to O. P. Petrushova.

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Original Russian Text © O.P. Petrushova, N.I. Mikulyak, 2013, published in Biomeditsinskaya Khimiya.

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Petrushova, O.P., Mikulyak, N.I. Peptidase activity of the fetoplacental complex in the norm and pathology. Biochem. Moscow Suppl. Ser. B 7, 243–246 (2013). https://doi.org/10.1134/S1990750813030116

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  • DOI: https://doi.org/10.1134/S1990750813030116

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