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Glycine receptors in the nervous tissue and their functional role

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Abstract

The literature data on glycine metabolism in neural tissue, the mitochondrial Gly-cleaving system, and the Gly uptake system in neural and glial cells are summarized. Brief description of localization and abundance of glycine receptors and specific binding sites in the mammalian nervous tissue is given. Four types of glycine binding receptors are described. These include own specific glycine receptor (GlyR), ionotropic glutamate receptor, which selectively binds N-methyl-D-aspartate selectively (NMDAR), and ionotropic receptors of γ-aminobutyrate (GABAAR, GABACR).

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  1. Polesskii State University, Pinsk, Belarus

    V. N. Nikandrov

  2. Institute of Physiology of the National Academy of Sciences of Belarus, ul. Academicheskaya 28, Minsk, 220072, Belarus

    T. V. Balashevich

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  1. V. N. Nikandrov
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Original Russian Text © V.N. Nikandrov, T.V. Balashevich, 2013, published in Biomeditsinskaya Khimiya.

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Nikandrov, V.N., Balashevich, T.V. Glycine receptors in the nervous tissue and their functional role. Biochem. Moscow Suppl. Ser. B 7, 202–211 (2013). https://doi.org/10.1134/S1990750813030104

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