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Computer search for molecular mechanisms of ulcerogenic action of non-steroidal anti-inflammatory drugs

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Abstract

Peptic ulcers are the most frequent side effect of therapy with non-steroidal anti-inflammatory drugs (NSAIDs). Good experimental evidence exists that pathogenesis of peptic ulcers cannot be attributed only to inhibition of cyclooxygenases. The knowledge about other molecular mechanisms of drug action associated with development of peptic ulcers could be useful for design of new safer NSAIDs. However, considerable time and material resources are needed for corresponding experimental studies. For simplification of the experimental search, we have developed an approach for in silico identification of putative molecular mechanisms of drug actions associated with their side effects. We have generated a data set of 85 NSAIDs, which includes information about their structures and side effects. Unknown molecular mechanisms of action of these NSAIDs were evaluated by the computer program PASS (Prediction of Activity Spectra for Substances) predicting more than 3000 molecular mechanisms of action based on structural formula of sub-stances. Statistically significant associations have been found between predicted molecular mechanisms of action and development of peptic ulcers. Twenty six molecular mechanisms of action probably associated with development of peptic ulcers have been found: two of them were known previously and 24 were quite new. Analyzing Gene Ontology data, data on signal and metabolic pathways, and available MEDLINE publication data, we proposed hypotheses on the role of 10 molecular mechanisms of action in the pathogenesis of peptic ulcer.

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Authors and Affiliations

  1. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, Moscow, ul. Pogodinskaya 10, 119121, Russia

    S. M. Ivanov, A. A. Lagunin, A. V. Zakharov, D. A. Filimonov & V. V. Poroikov

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  1. S. M. Ivanov
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  2. A. A. Lagunin
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  3. A. V. Zakharov
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  4. D. A. Filimonov
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  5. V. V. Poroikov
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Correspondence to S. M. Ivanov.

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Original Russian Text © S.M. Ivanov, A.A. Lagunin, A.V. Zakharov, D.A. Filimonov, V.V. Poroikov, 2013, published in Biomeditsinskaya Khimiya.

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Ivanov, S.M., Lagunin, A.A., Zakharov, A.V. et al. Computer search for molecular mechanisms of ulcerogenic action of non-steroidal anti-inflammatory drugs. Biochem. Moscow Suppl. Ser. B 7, 40–45 (2013). https://doi.org/10.1134/S199075081301006X

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  • DOI: https://doi.org/10.1134/S199075081301006X

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