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The effect of melatonin on the antioxidant status of rats with type II diabetes mellitus

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Abstract

The effect of melatonin on the intensity of free radical processes and activities of superoxide dismutase (SOD, EC 1.15.1.1.) and catalase (EC 1.11.1.6) has been investigated in liver and blood serum of rats with type II diabetes mellitus. According to results of this study the development of diabetes was accompanied by the increase in biochemiluminescence parameters and the enzyme activities studied. Melatonin administration changed the parameters studied towards control values and this is obviously associated with realization of the antioxidant potential of this hormone.

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References

  1. Balabolkin, M.I., Kreminskaya, V.M., and Klebanova, E.M., Rol’ disfunktsii endoteliya i okislitel’nogo stressa v mekhanizmakh razvitiya angiopatii pri sakharnom diabete 2-go tipa (The Role of Endothelial Dysfunction and Oxidative Stress in Mechanisms Underlying Development of Angiopathy in Type 2 Diabetes Mellitus), Moscow: Mediasphera, 2005.

    Google Scholar 

  2. Julien, J., Diab. Compl., 1997, vol. 11, pp. 123–130.

    Article  CAS  Google Scholar 

  3. Ramakrishna, V. and Jailkhani, R., Acta Diabetol., 2008, vol. 45, pp. 41–46.

    Article  CAS  Google Scholar 

  4. Soliman, G.Z., (2008) Singapore Med. J., 2008, vol. 49, pp. 129–136.

    CAS  Google Scholar 

  5. Goodarzi, M.T., Varmaziar, L., Navidi, A.A., and Parivar, K., Saudi Med. J., 2008, vol. 29, pp. 503–506.

    Google Scholar 

  6. Baynes, J.W. and Thorpe, J.W., Diabetes, 1999, vol. 48, pp. 1–9.

    Article  CAS  Google Scholar 

  7. Rajeswari, P., Natarajan, R., Nadler, J.L., Kumar, D., and Kalra, V.K., J. Cell. Physiol., 1991, vol. 149, pp. 100–109.

    Article  CAS  Google Scholar 

  8. Antonova, K.V., and Nedosugova, L.V., Trudnyi Patsient, 2008, vol. 6, no. 10, pp. 17–22.

    Google Scholar 

  9. Kazimirko, V.K., Mal’tsev, V.I., Butylin, V.Yu., and Gorobets, N.I., Svobodnoradikal’noe okislenie i antioxidantnaya terapiya (Free Radical oxidation and Antioxidant Therapy), Morion, 2004.

  10. Kulinsky, V.I., Soros Obrazovat. Zh., 1999, no. 1, pp. 2–7.

  11. Popova, T.N., Pashkov, A.N., Semenikhina, A.V., Popov, S.S., and Rakhmanova, T.I., Svobodnoradikal’nyie protsessy v biosistemakh: uchebnoe posobie (Free Radical Processes in Biosystems: A textbook), Staryi Oskol: Kirillitsa, 2008.

    Google Scholar 

  12. Reyes-Toso, C.F., Ricci, C.R., De Mignone, I.R., Reyes, P., Linares, L.M., Albornoz, L.E., Cardinali, D.P., and Zaninovich, A., Neuroendocrinol. Lett., 2003, vol. 24, pp. 341–344.

    CAS  Google Scholar 

  13. Floyd, R.A., West, M.S., Eneff, K.L., and Schneider, J.E., Arch. Biochem. Biophys., 1991, vol. 273, pp. 106–111.

    Article  Google Scholar 

  14. Ulyanov, A.M. and Tarasov, Yu.A., Vopr. Med. Khim., 2000, vol. 46, pp. 149–154.

    Google Scholar 

  15. Kuz’menko, A.I., Morozova, R.P., Nikolenko, I.A., Kornietz, G.V., and Kholodova, Yu.A., Biochemistry (Moscow), 1997, vol. 62, pp. 712–715.

    Google Scholar 

  16. Matyushin, B.N., Loginov, A.S., and Tkachev, V.D., Lab. Delo, no. 7, pp. 16–19.

  17. Korolyuk, M.A., Ivanova, L.I., Maiorova, I.G., et. al., Lab. Delo, no. 1, pp. 16–19.

  18. Baynes, J.W. and Thorpe, J.W., Diabetes, 1999, vol. 48, pp. 1–9.

    Article  CAS  Google Scholar 

  19. Balabolkin, M.I. and Klebanova, E.M., Probl. Endokrinol. 2000, no. 6, pp. 29–34.

  20. Delyanin, N.V. and Gerasimov, A.M., Mechanisms of Antioxidant Defense During Changes of Oxygen Supply. Materials of Intentional Scientific Conference, Grondo, 1993, pp. 18–19.

  21. Shaker, M.E., Houssen, M.E., Abo-Hashem, E.M., and Ibrahim, T.M., J. Physiol. Biochem., 2009, vol. 65, pp. 225–234.

    Article  CAS  Google Scholar 

  22. Oliveira, H.R., Curi, R., and Carpinelli, A.R., Am. J. Physiol., 1999, vol. 276, 507–510.

    Google Scholar 

  23. Dubinina, E.E., Vopr. Med. Khim., 2001, vol. 47, pp. 561–581.

    CAS  Google Scholar 

  24. Reiter, R.J., Tan, D.-X., Osuna, C., and Gitto, E., J. Biomed. Sci., 2000, vol. 7, pp. 444–458.

    Article  CAS  Google Scholar 

  25. Peschke, E.J., Pineal Res., 2008, vol. 44, pp. 26–40.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Biology and Soil Science Faculty, Department of Medical Biochemistry and Microbiology, Voronezh State University, Universitetskaya pl. 1, Voronezh, 394006, Russia

    A. A. Agarkov, T. N. Popova & L. V. Matasova

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  1. A. A. Agarkov
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  2. T. N. Popova
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  3. L. V. Matasova
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Correspondence to A. A. Agarkov.

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Original Russian Text © A. A. Agarkov, T. N. Popova, and L. V. Matasova, 2012, published in Biomeditsinskaya Khimiya.

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Agarkov, A.A., Popova, T.N. & Matasova, L.V. The effect of melatonin on the antioxidant status of rats with type II diabetes mellitus. Biochem. Moscow Suppl. Ser. B 6, 231–236 (2012). https://doi.org/10.1134/S199075081203002X

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  • DOI: https://doi.org/10.1134/S199075081203002X

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