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The effect of oxidized dextrans on generation of reactive oxygen species by murine peritoneal exudate phagocytes

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Abstract

The effects of oxidized dextrans of different molecular masses on reactive oxygen species production and mitochondrial transmembrane potential of macrophages and neutrophils have been studied in vivo and in vitro. Oxidized dextrans demonstrated moderate direct antioxidant properties but induced intracellular oxidative stress through the increase of oxygen radical generation. This effect of the investigated compounds amplifies the cytotoxic and bactericidal potential of phagocytes and in addition it can influence isoniazid metabolism, thus increasing its efficiency in therapy of infectious diseases.

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Authors and Affiliations

  1. Research Center of Clinical and Experimental Medicine Siberian Branch of Russian Academy of Medical Sciences, ul. Akad. Timakova 2, Novosibirsk, 630117, Russia

    V. O. Tkachev, M. V. Zaikovskaya, A. V. Troitsky, N. G. Luzgina & V. A. Shkurupy

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  1. V. O. Tkachev
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  2. M. V. Zaikovskaya
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  3. A. V. Troitsky
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  4. N. G. Luzgina
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  5. V. A. Shkurupy
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Correspondence to V. O. Tkachev.

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Original Russian Text © V.O. Tkachev, M.V. Zaikovskaya, A.V. Troitsky, N.G. Luzgina, V.A. Shkurupy, 2012, published in Biomeditsinskaya Khimiya.

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Tkachev, V.O., Zaikovskaya, M.V., Troitsky, A.V. et al. The effect of oxidized dextrans on generation of reactive oxygen species by murine peritoneal exudate phagocytes. Biochem. Moscow Suppl. Ser. B 6, 144–148 (2012). https://doi.org/10.1134/S199075081202014X

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  • DOI: https://doi.org/10.1134/S199075081202014X

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