Abstract
The effect of guanidine derivatives on citrate content and activity of aconitate hydratase and citrate synthase have been investigated in rats with cerebral ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Administration of these biguanidines compounds also decreased the degree of DNA fragmentation, which was markedly increased in rats with ischemia-reperfusion. The dose-dependent effects of guanidine derivatives suggest that they exhibit not only antioxidant but also prooxidant effects.
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Original Russian Text © O.V. Sukhoveeva, T.N. Popova, A.V. Makeeva, I.Yu. Iskusnykh, 2012, published in Biomeditsinskaya Khimiya.
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Sukhoveeva, O.V., Popova, T.N., Makeeva, A.V. et al. The influence of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine on citrate content, activities of aconitase and citrate synthase in rats exposed to cerebral ischemia-reperfusion. Biochem. Moscow Suppl. Ser. B 6, 171–176 (2012). https://doi.org/10.1134/S1990750812020138
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DOI: https://doi.org/10.1134/S1990750812020138