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The diagnostic value of RNA oncomarkers in evaluation of malignant breast tumors

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Abstract

The levels of the RNA oncomarkers, telomerase (hTERT), cytokeratin-19 (CK-19), and mammaglobin (MAM) have been investigated in capillary blood of female patients with mammary ductal carcinoma. The study revealed overexpression of all three factors in patients with this pathology. This overexpression was not found in healthy donors and female patients with mammary fibroadenoma. Levels of the RNA oncomarkers return to the normal level within 10 days after successful tumor resection. These results have been used for the development of diagnostic kits, which may be applicable for differential diagnostics, screening and postoperation monitoring of patients with malignant breast tumors.

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Authors and Affiliations

  1. Institute of Agricultural Biotechnology, Russian Academy of Agricultural Sciences, ZAO Sintol, Timiryazevskaya ul. 42, Moscow, 127550, Russia

    A. G. Globa, Ya. I. Alekseev & D. A. Varlamov

  2. Vishnevsky Institute of Surgery, ul. Bolshaya Serpukhovskaya 27, Moscow, Russia

    A. A. Vishnevsky

Authors
  1. A. G. Globa
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  2. Ya. I. Alekseev
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  3. D. A. Varlamov
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  4. A. A. Vishnevsky
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Correspondence to A. G. Globa.

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Original Russian Text © A.G. Globa, Ya.I. Alekseev, D.A. Varlamov, A.A. Vishnevsky, 2012, published in Biomeditsinskaya Khimiya.

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Globa, A.G., Alekseev, Y.I., Varlamov, D.A. et al. The diagnostic value of RNA oncomarkers in evaluation of malignant breast tumors. Biochem. Moscow Suppl. Ser. B 6, 201–203 (2012). https://doi.org/10.1134/S1990750812020060

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  • DOI: https://doi.org/10.1134/S1990750812020060

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