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Anticancer activity of oxovanadium compounds

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Abstract

Cytotoxic and antitumor activities of the biligand vanadyl derivative of L-malic acid, (bis-(L-malato)oxovanadium(IV) (VO(mal)2), the inorganic vanadium(IV) compound, vanadyl sulfate (VOSO4), the oxovanadium monocomplex with L-malic acid (VO(mal)), and the vanadyl biscomplex with acetylacetonate (VO(acac)2) were investigated using several tumor cell lines: mouse fibrosarcoma (L929), rat pheochromocytoma (PC12), human liver carcinoma (HepG2), mouse embryonic fibroblasts (NIH/3T3), and also normal human skin fibroblasts. The results showed that VO(mal)2 effectively inhibited growth of cancer cell cultures without any toxic effect on normal human skin fibroblasts. The cytotoxic anticancer effect of vanadium complexes depended on concentration of the compounds studied, incubation time, types of cell cultures, and nature of ligands surrounding the central group of the complex (VO2+). These studies provide evidence that VO(mal)2 may be considered as a potential anticancer agent due to its low toxicity for non-tumor cells and significant anticancer activity.

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Authors and Affiliations

  1. Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences, ul. Pogodinskaya 10, Moscow, 119121, Russia

    O. Yu. Abakumova, O. V. Podobed, N. F. Belayeva & A. I. Tochilkin

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  1. O. Yu. Abakumova
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  2. O. V. Podobed
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  3. N. F. Belayeva
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  4. A. I. Tochilkin
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Correspondence to N. F. Belayeva.

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Original Russian Text © O.Yu. Abakumova, O.V. Podobed, N.F. Belayeva, A.I. Tochilkin, 2012, published in Biomeditsinskaya Khimiya.

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Abakumova, O.Y., Podobed, O.V., Belayeva, N.F. et al. Anticancer activity of oxovanadium compounds. Biochem. Moscow Suppl. Ser. B 6, 164–170 (2012). https://doi.org/10.1134/S1990750812020023

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  • DOI: https://doi.org/10.1134/S1990750812020023

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