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Changes of doxorubicin distribution in blood and plasma after its inclusion into nanophospholipid formulations

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Abstract

Using original technology developed at the Institute of Biomedical Chemistry (Russian Academy of Medical Sciences) a drug composition based on plant phospholipids and the antitumor drug doxorubicin (particle size <30 nm) has been developed. In vitro experiments demonstrated that doxorubicin inclusion into the phospholipids nanoparticles decreased drug binding to blood cells and thus increase proportion of the potentially active drug in plasma. This was accompanied by changes in drug redistribution from the plasma protein fraction to high density lipoproteins. Importance of these changes for doxorubicin bioavailability and antitumor activity is discussed.

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Authors and Affiliations

  1. Institute of Biomedical Chemistry, Russian Academy of Sciences, ul. Pogodinskaya 10, Moscow, 119121, Russia

    M. G. Zykova, O. M. Ipatova, V. N. Prozorovskii, N. V. Medvedeva, A. A. Voskresenskaya, T. S. Zakharova & T. I. Torkhovskaya

Authors
  1. M. G. Zykova
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  2. O. M. Ipatova
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  3. V. N. Prozorovskii
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  4. N. V. Medvedeva
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  5. A. A. Voskresenskaya
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  6. T. S. Zakharova
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  7. T. I. Torkhovskaya
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Corresponding author

Correspondence to T. I. Torkhovskaya.

Additional information

Original Russian Text © M.G. Zykova, O.M. Ipatova, V.N. Prozorovskii, N.V. Medvedeva, A.A. Voskresenskaya, T.S. Zakharova, T.I. Torkhovskaya, 2012, published in Biomeditsinskaya Khimiya.

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Zykova, M.G., Ipatova, O.M., Prozorovskii, V.N. et al. Changes of doxorubicin distribution in blood and plasma after its inclusion into nanophospholipid formulations. Biochem. Moscow Suppl. Ser. B 6, 39–41 (2012). https://doi.org/10.1134/S1990750812010155

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  • DOI: https://doi.org/10.1134/S1990750812010155

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