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Catecholamine metabolism in children with Asperger’s and Kanner’s syndromes

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Abstract

In a stable state children with Asperger’s and Kanner’s syndromes demonstrate a similar decrease in plasma norepinephrine. In the aggravated state, these changes become more expressed and are characterized by a decrease in plasma tyrosine, norepinephrine, normetanephrine, and by an increase in dopamine and homovanillic acid and a decrease in excretion of norepinephrine and an increase in excretion of homovanillic acid, epinephrine and 3-methoxy-4-hydroxyphenylglycol (MHPG). In the aggravated state children with Kanner’s syndrome were characterized by increased plasma MHPG, decreased excretion of tyrosine and increased expression of normetanephrine. The observed imbalance in dopamine and epinephrine/norepinephrine systems suggests importance of combined analysis of changes in catecholamines and their metabolites as the most informative approach in the study of the effect of autistic disorders.

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Authors and Affiliations

  1. Sick Children Hospital, Research Institute, Toronto, Canada

    A. S. Gorina

  2. Chair of Chemistry, Irkutsk State Medical University, ul. Krasnogo Vosstaniya 1, Irkutsk, 664003, Russia

    L. S. Kolesnichenko

  3. National Center for Health Family Problems and Human Reproduction, Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia

    V. I. Mikhnovich

Authors
  1. A. S. Gorina
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  2. L. S. Kolesnichenko
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  3. V. I. Mikhnovich
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Correspondence to L. S. Kolesnichenko.

Additional information

Original Russian Text © A.S. Gorina, L.S. Kolesnichenko, V.I. Mikhnovich, 2011, published in Biomeditsinskaya Khimiya.

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Gorina, A.S., Kolesnichenko, L.S. & Mikhnovich, V.I. Catecholamine metabolism in children with Asperger’s and Kanner’s syndromes. Biochem. Moscow Suppl. Ser. B 5, 397–401 (2011). https://doi.org/10.1134/S1990750811040044

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  • DOI: https://doi.org/10.1134/S1990750811040044

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