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Peculiarities of functional activity of circulating phagocytes in patients with different forms of drug-resistant pulmonary tuberculosis

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Abstract

Functional activity of circulating phagocytes (macrophages and neutrophils — Ns) was studied in 30 patients with infiltrative and 30 patients with fibro-cavernous pulmonary tuberculosis (IPT and FCPT, respectively), characterized by similar biological properties of mycobacterium tuberculosis (MTB), dissemination of the process, and manifestations of intoxication. Differences of the functional activity of both types of cells depending on the PT form were found: a more significant increase in the oxygen-depending activity in FCPT while bactericide potential estimated with the zymosan induced NST-test was more pronounced in IPT patients. These data correlate with the blood levels of neopterin and elastase, the markers of the mononuclear and neutrophil activity, respectively. Involvement of adenosine deaminase (ADA) and neopterin in realization of intracellular oxygen-dependent processes was demonstrated. Results of the multivariate analysis of the whole set of the studied phagocyte parameters, reflecting their different roles in this pathological process demonstrated a prevailing role of mononuclears in newly diagnosed IPT and neutrophils in the chronic progressive process.

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Authors and Affiliations

  1. Research Institute of Phthisiopulmonology, ul. Polytekhnicheskaya, 32, St. Petersburg, 194064, Russia

    O. T. Titarenko, M. E. Dyakova, D. S. Esmedlyaeva, M. V. Pavlova, A. V. Yelkin, N. P. Alekseeva & B. B. Bondarenko

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  1. O. T. Titarenko
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  2. M. E. Dyakova
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  3. D. S. Esmedlyaeva
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  4. M. V. Pavlova
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  5. A. V. Yelkin
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  6. N. P. Alekseeva
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  7. B. B. Bondarenko
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Correspondence to M. E. Dyakova.

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Original Russian Text © O.T. Titarenko, M.E. Dyakova, D.S. Esmedlyaeva, M.V. Pavlova, A. V. Yelkin, N.P. Alekseeva, B.B. Bondarenko, 2011, published in Biomeditsinskaya Khimiya.

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Titarenko, O.T., Dyakova, M.E., Esmedlyaeva, D.S. et al. Peculiarities of functional activity of circulating phagocytes in patients with different forms of drug-resistant pulmonary tuberculosis. Biochem. Moscow Suppl. Ser. B 5, 301–306 (2011). https://doi.org/10.1134/S1990750811030152

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  • DOI: https://doi.org/10.1134/S1990750811030152

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