Abstract
In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus we have originally synthesized a biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV)) and investigated its potential as a novel hypoglycemic agent using the experimental streptozotocin-induced diabetes in rats. The oral administration of bis(L-malato)oxovanadium(IV) with drinking water significantly reduced blood and urinary glucose concentrations and also the level of glycated proteins in the streptozotocin-diabetic rats.
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Original Russian Text © V.K. Gorodetskii, A.I. Tochilkin, N.F. Belayeva, I.R. Kovelman, B.F. Korovkin, 2011, published in Biomeditsinskaya Khimiya.
The idea of the development of the vanadyl complex with malic acid was originally proposed by B. F. Korovkin.
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Gorodetskii, V.K., Tochilkin, A.I., Belayeva, N.F. et al. Synthesis and hypoglycemic activity of Bis(L-malato)oxovanadium(IV). Biochem. Moscow Suppl. Ser. B 5, 260–262 (2011). https://doi.org/10.1134/S1990750811030048
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DOI: https://doi.org/10.1134/S1990750811030048