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Mechanisms of the anticancer effects of plant polyphenols. I. Blockade of initiation of carcinogenesis

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Abstract

Mechanisms of the anticancer effects of polyphenols, found in fruits, vegetables, spices and representing parts of daily nutrition, have been considered. These compounds may be the basis for the development of cancer preventive preparations. They can block initiation of carcinogenesis by inactivating exogenous or endogenous genotoxic molecules including reactive oxygen species (ROS). The other mechanism underlying polyphenol effects consists in inhibition of activity and synthesis of carcinogen-metabolizing enzymes. Plant polyphenols can induce expression of genes encoding antioxidant and detoxification enzymes and this also prevents initiation of carcinogenesis.

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  1. Research Institute of Pharmacology and Department of Pharmacology, Volgograd State Medical University, pl. Pavshikh Bortsov 1, Volgograd, 400131, Russia

    V. N. Zinov’eva & A. A. Spasov

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  1. V. N. Zinov’eva
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Original Russian Text © V.N. Zinov’eva, A.A. Spasov, 2011, published in Biomeditsinskaya Khimiya.

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Zinov’eva, V.N., Spasov, A.A. Mechanisms of the anticancer effects of plant polyphenols. I. Blockade of initiation of carcinogenesis. Biochem. Moscow Suppl. Ser. B 5, 113–123 (2011). https://doi.org/10.1134/S1990750811020181

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