Abstract
A covalent bienzyme superoxide dismutase-chondroitin sulfate-catalase conjugate (SOD-CHS-CAT) demonstrated the dose-dependent inhibitory action on induced platelet aggregation both in the presence and the absence of hydrogen peroxide. The antioxidant activity of SOD-CHS-CAT was noted at much lower doses than that of other CAT derivatives. The conjugate SOD-CHS-CAT inhibited platelet aggregation regardless of the nature of inducers; it also prevented platelet spreading on the glass surface. The latter suggests conjugate influence on adhesive properties of platelets. Novel properties of the SOD-CHS-CAT conjugate underlie prospects of its biopharmaceutical applicability as a tool for antioxidant therapy.
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Original Russian Text © A.V. Vavaev, L.I. Bouryachkovskaya, E.G. Tischenko, I.A. Uchitel, A.V. Maksimenko, 2011, published in Biomeditsinskaya Khimiya.
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Vavaev, A.V., Bouryachkovskaya, L.I., Tischenko, E.G. et al. The antioxidant and antiaggregant effects of the covalent bienzyme superoxide dismutase — Chondroitin sulfate — Catalase conjugate on platelets. Biochem. Moscow Suppl. Ser. B 5, 163–170 (2011). https://doi.org/10.1134/S199075081102017X
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DOI: https://doi.org/10.1134/S199075081102017X