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The analysis of interaction of lipoproteins and steroid hormones

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Abstract

Using the methods of gel-filtration and fluorescence quenching, it has been demonstrated that plasma lipoproteins bind steroid hormones and can therefore play a role in their active transport in the body. High density lipoproteins demonstrate the highest affinity for steroids.

The lipoprotein-steroid complex formation involves the protein components of lipoproteins with the apolipoprotein A-I as one the protein components responsible for binding of steroid hormones. The calculated constants of the complex formation between lipoproteins and steroid hormones suggest specificity of this binding. The data obtained suggest a real possibility of penetration of steroid hormones into cells by a receptor-mediated endocytosis using the lipoprotein complexes as a vehicle.

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Authors and Affiliations

  1. Institute of Biochemistry, Siberian Division, Russian Academy of Medical Sciences, ul. Timakova 2, Novosibirsk, 630117, Russia

    L. M. Polyakov, D. V. Sumenkova, R. A. Knyazev & L. E. Panin

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  1. L. M. Polyakov
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  2. D. V. Sumenkova
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  3. R. A. Knyazev
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  4. L. E. Panin
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Correspondence to L. M. Polyakov.

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Original Russian Text © L.M. Polyakov, D.V. Sumenkova, R.A. Knyazev, L.E. Panin, 2010, published in Biomeditsinskaya Khimiya.

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Polyakov, L.M., Sumenkova, D.V., Knyazev, R.A. et al. The analysis of interaction of lipoproteins and steroid hormones. Biochem. Moscow Suppl. Ser. B 4, 362–365 (2010). https://doi.org/10.1134/S1990750810040062

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  • DOI: https://doi.org/10.1134/S1990750810040062

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