Abstract
Application of blood plasma metabolites fingerprinting for the diagnostic of the 2nd stage of prostate cancer has been investigated. The diagnostic sensitivity (95%), specificity (96.7%) and accuracy (95.7%) of the metabolic fingerprinting were much higher then those for the ELISA PSA test (35%, 83.3% and 51.7%, respectively) performed for the same patients. Area under the ROC curve (0.994) suggests that the proposed approach based on the metabolic fingerprinting is effective and applicable in clinical practice.
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Original Russian Text © P.G. Lokhov, M.I. Dashtiev, L.V. Bondartsov, A.V. Lisitsa, S.A. Moshkovskii, A.I. Archakov, 2010, published in Biomeditsinskaya Khimiya.
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Lokhov, P.G., Dashtiev, M.I., Bondartsov, L.V. et al. Metabolic fingerprinting of blood plasma from patients with prostate cancer. Biochem. Moscow Suppl. Ser. B 4, 37–41 (2010). https://doi.org/10.1134/S1990750810010051
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DOI: https://doi.org/10.1134/S1990750810010051