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Cathepsin K and matrix metalloprotease activities in bone tissue of the OXYS rats during the development of osteoporosis

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Abstract

The activity of osteoclast-specific cysteine protease, cathepsin K, and matrix metalloproteases (MMPs) has been investigated in bone tissue of senescence-accelerated OXYS rats and in Wistar rats. At the age of 3 month (the period preceding manifestation of osteoporosis in OXYS rats) cathepsin K activity was higher whereas MMP activity was lower in Wistar rats. At the age of 14 months Wistar rats cathepsin K activity increased and MMP activity decreased. The age-related changes in bone cathepsin K and MMP activity of OXYS rats had opposite direction. Thus, despite of marked manifestations of osteoporosis previously found by us in OXYS rats (the decrease in mineralization density of the bone tissue and its resorption) no interstrain differences in cathepsin K and MMPs were found between Wistar and OXYS rats. Activity of a universal protease inhibitor, α2-macroglobulin, was higher in serum of 14-month old OXYS rats than in Wistar rats of the same age. The role of cathepsin K activation in resorption of bone tissue in the development of osteoporosis in senescence-accelerated OXYS rats is discussed.

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Authors and Affiliations

  1. Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, ul. Timakova 4, Novosibirsk, 630117, Russia

    A. A. Venediktova & T. A. Korolenko

  2. Federal State Research Institute of Traumatology and Orthopedics, Federal Agency of Medical High Technology Assistance, ul. Frunze 17, Novosibirsk, 630091, Russia

    O. V. Falameeva & M. A. Sadovoj

  3. Institute of Cytology and Genetics, Sibirian Branch, Russian Academy of Sciences, pr. Lavrent’eva 10, Novosibirsk, 630090, Russia

    N. G. Kolosova

Authors
  1. A. A. Venediktova
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  2. O. V. Falameeva
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  3. N. G. Kolosova
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  4. M. A. Sadovoj
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  5. T. A. Korolenko
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Correspondence to A. A. Venediktova.

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Original Russian Text © A.A. Venediktova, O.V. Falameeva, N.G. Kolosova, M.A. Sadovoj, T.A. Korolenko, 2009, published in Biomeditsinskaya Khimiya.

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Venediktova, A.A., Falameeva, O.V., Kolosova, N.G. et al. Cathepsin K and matrix metalloprotease activities in bone tissue of the OXYS rats during the development of osteoporosis. Biochem. Moscow Suppl. Ser. B 3, 393–398 (2009). https://doi.org/10.1134/S1990750809040106

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  • DOI: https://doi.org/10.1134/S1990750809040106

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