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Immunochemical and molecular-Genetic markers in diagnostics of gastric cancer

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Abstract

Intensive studies of molecular mechanisms responsible for tumor transformation results in identification of new proteins and their genes involved into tumor development. These proteins may be used as markers of tumor transformation of cells and the level of their expression may be evaluated by means of modern highly sensitive and technological methods of analysis. This review summarized literature data on currently used immunohistochemical and molecular genetic markers of gastric cancer. It highlights genetic and epigenetic changes detected in nucleic acids of tumor tissue cells in malignant and benign gastric diseases as well as in the level of DNA circulating in blood of patients with gastric cancer.

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References

  1. Parkin, M., Bray, F., Ferlay, J., and Pisani, P., CA Cancer J. Clin., 2005, vol. 55, pp. 74–108.

    Article  Google Scholar 

  2. Merabishvili, V.M., Prakticheskaya Onkologiya, 2001, vol. 3(7), pp. 3–8.

    Google Scholar 

  3. Aksel’, E.M. and Davydov, M.I., Zlokachestvennye novoobrazovaniya v Rossii i stranakh SNG v 2000 g. (Malignant Tumors in Russia and in CIS Countries) RONTs im. N.N. Blokhina RAMN, Moscow, 2002, pp. 85–106.

    Google Scholar 

  4. Simonov, N.N., Myaukina, L.M., Filin, A.V, and Rybalkin, Yu.I., Prakticheskaya onkologiya, 2001, vol. 3(7), pp. 25–30.

    Google Scholar 

  5. Belokhvostov, A.S. and Rumyantsev, A.G., Onkomarkery (Oncomarkers), Moscow, 2003.

  6. Tocchi, A., Costa, G., Lepre, L., Liotta, G., Mazzoni, G., Cianetti, A., and Vannini, P., J. Cancer Res. Clin. Oncol., 1998, vol. 124, pp. 450–455.

    Article  CAS  Google Scholar 

  7. Takahashi, Y., Takeuchi, T., Sakamoto, J., Touge, T., Mai, M., Ohkura, H., Kodaira, S., Okajima, K., Nakazato, H., and Committee, M., Gastric Cancer, 2003, vol. 6, pp. 142–145.

    Article  Google Scholar 

  8. Guadagni, F., Roselli, M., Amato, T., Cosimelli, M., Perri, P., Casale, V., Carlini, M., Santoro, E., Cavaliere, R., Greiner, J.W., and Schlom, J., Cancer Res., 1992, vol. 52, pp. 1222–1227.

    CAS  Google Scholar 

  9. Guadagni, F., Roselli, M., Amato, T., Cosimelli, M., Mannella, E., Perri, P., Abbolito, M.R., Cavaliere, R., Colcher, D., Greiner, J.W., and Schlom, J., Cancer, 1991, vol. 68, pp. 2443–2450.

    Article  CAS  Google Scholar 

  10. Mattar, R., Alves e Andrade, C.R., DiFavero, G.M., Gama-Rodrigues, J.J., and Laudanna, A.A., Rev. Hosp. Clin. Fac. Med. Sao Paulo, 2002, vol. 57, pp. 89–92.

    Google Scholar 

  11. Ychou, M., Duffour, J., Kramar, A., Gourgou, S., and Grenier, J., Disease Markers, 2000, vol. 16(3–4), pp. 105–110.

    CAS  Google Scholar 

  12. Tachibana, M., Takemoto, Y., Nakashima, Y., Kinugasa, S., Kotoh, T., Dhar, D.K., Kohno, H., and Nagasue, N., J. Am. Coll. Surg., 1998, vol. 187, pp. 64–68.

    Article  CAS  Google Scholar 

  13. Gaspar, M.J., Arribas, I., Coca, M.C., and Diez-Alonso, M., Tumor Biol., 2001, vol. 22, pp. 318–322.

    Article  CAS  Google Scholar 

  14. Marrelli, D., Roviello, F., De Stefano, A., Farnetani, M., Garosi, L., Messano, A., and Pinto, E., Oncology, 1999, vol. 5, pp. 55–62.

    Article  Google Scholar 

  15. Choi, S.R., Jang, J.S., Lee, J.H., Roh, M.H., Kim, M.C., Lee, W.S., and Qureshi, W., Dig. Dis. Sci., 2006, vol. 51, pp. 2081–2086.

    Article  CAS  Google Scholar 

  16. Marrelli, D., Pinto, E., De Stefano, A., Farnetani, M., Garosi, L., and Roviello, F., Am. J. Surgery, 2001, vol. 181, pp. 16–19.

    Article  CAS  Google Scholar 

  17. Bergstrand, C.G. and Czar, D., Scand. J. Clin. Lab. Invest., 1956, vol. 8, p. 174.

    Article  CAS  Google Scholar 

  18. Inagawa, S., Shimazaki, J., Hori, M., Yoshimi, F., Adachi, S., Kawamoto, T., Fukao, K., and Itabashi, M., Gastric Cancer, 2001, vol. 4, pp. 43–52.

    Article  CAS  Google Scholar 

  19. Kono, K., Amemiya, H., Sekikawa, T., Iizuka, H., Takahashi, A., Fujii, H., and Matsumoto, Y., Dig. Surg., 2002, vol. 19, pp. 359–365.

    Article  CAS  Google Scholar 

  20. Goonetilleke, K.S. and Siriwardena, A.K., EJSO, 2007, vol. 33, pp. 266–270.

    Article  CAS  Google Scholar 

  21. Tas, F., Aykan, N.F., Aydiner, A., Yasasever, V., and Topuz, E., Am. J. Clin. Oncol., 2001, vol. 24(2), pp. 148–149.

    Article  CAS  Google Scholar 

  22. Duraker, N., Celik, A.N., and Gencler, N., EJSO, 2002, vol. 28, pp. 844–849.

    Article  CAS  Google Scholar 

  23. Lengauer, C., Kinzler, K.W., and Volgelstien, B., Nature, 1998, vol. 396, pp. 643–649.

    Article  CAS  Google Scholar 

  24. Egger, G., Liang, G., Aparicio, A., and Jones, P.A., Nature, 2004, vol. 429, pp. 457–463.

    Article  CAS  Google Scholar 

  25. Herman, J.G. and Baylin, S.B., N. Engl. J. Med., 2003, vol. 349, pp. 2042–2054.

    Article  CAS  Google Scholar 

  26. Esteller, M., Oncogene, 2002, vol. 21, pp. 5427–5440.

    Article  CAS  Google Scholar 

  27. Hamilton, J.P. and Meltzer, S.J., Clin. Gastroenterol. Hepatol., 2006, vol. 4, pp. 416–425.

    Article  CAS  Google Scholar 

  28. Fenoglio-Preiser, C.M., Wang, J., Stemmermann, G.N., and Noffsinger, A., Human Mutation, 2003, vol. 21, pp. 258–270.

    Article  CAS  Google Scholar 

  29. Kusano, M., Toyota, M., Suzuki, H., Akino, K., Aoki, F., Fujita, M., Hosokawa, M., Shinomura, Y., Imai, K., and Tokino, T., Cancer, 2006, vol. 106, pp. 1467–1479.

    Article  CAS  Google Scholar 

  30. Tajima, Y., Yamazaki, K., Makino, R., Nishino, N., Aoki, S., Kato, M., Morohara, K., Kaetsu, T., and Kusano, M., Clin. Cancer Res., 2006, vol. 12, pp. 6469–6479.

    Article  CAS  Google Scholar 

  31. Tajima, Y., Yamazaki, K., Makino, R., Nishino, N., Masuda, Y., Aoki, S., Kato, M., Morohara, K., and Kusano, M., Br. J. Cancer, 2007, vol. 96, pp. 631–638.

    Article  CAS  Google Scholar 

  32. Wang, J.-Y., Hsieh, J.-S., Chen, C.-C., Tzou, W.-S., Cheng, T.-L., Chen, F.-M., Huang, T.-J., Huang, Y.-S., Huang, S.-Y., Yang, T., and Lin, S.-R., J. Surgical Res., 2004, vol. 120, pp. 242–248.

    Article  CAS  Google Scholar 

  33. Juvan, R., Hudler, P., Gazvoda, B., Repse, S., Bracko, M., and Komel, R., Croat Med. J., 2007, vol. 48, pp. 207–217.

    CAS  Google Scholar 

  34. Oue, N., Mitani, Y., Motoshita, J., Matsumura, S., Yoshida, K., Kuniyasu, H., Nakayama, H., and Yasui, W., Cancer, 2006, vol. 106, pp. 1250–1259.

    Article  CAS  Google Scholar 

  35. Lu, C., Xu, H.-M., Ren, Q., Ao, Y., Wang, Z.-N., Ao, X., Jiang, L., Luo, Y., and Zhang, X., World J. Gastroenterol., 2003, vol. 9, pp. 2662–2665.

    CAS  Google Scholar 

  36. El-Rifai, W. and Powell, S.M., Semin. Radiat. Oncol., 2002, vol. 12(2), pp. 128–140.

    Article  Google Scholar 

  37. Vauhkonen, M., Vauhkonen, H., and Sipponen, P., Best. Practice and Research Clinical Gastoenterology, 2006, vol. 20, pp. 651–674.

    Article  CAS  Google Scholar 

  38. Zheng, L., Wang, L., Ajani, J., and Xie, K., Gastric Cancer, 2004, vol. 7, pp. 61–77.

    Article  Google Scholar 

  39. Shiao, Y.H., Rugge, M., Correa, P., Lehmann, H.P., and Scheer, W.D., Am. J. Pathol., 1994, vol. 144(3), pp. 511–517.

    CAS  Google Scholar 

  40. Murakami, K., Fujioka, T., Okimoto, T., Mitsuishi, Y., Oda, T., Nishizono, A., and Nasu, M., Scand. J. Gastroenterology., 1999, vol. 34, pp. 474–477.

    Article  CAS  Google Scholar 

  41. Kopnin, B.P., Biochemistry (Moscow), 2000, vol. 65, pp. 5–33.

    Google Scholar 

  42. Lee, J.-H., Abraham, S.C., Kim, H.-S., Nam, J.-H., Choi, C., Lee, M.-C., Park, C.-S., Juhng, S.-W., Rashid, A., Hamilton, S.R., and Wu, T.-T., Am. J. Pathol., 2002, vol. 161, pp. 611–618.

    CAS  Google Scholar 

  43. Woo, D.K., Kim, H.S., Lee, H.S., Kang, Y.H., Yang, H.K., and Kim, W.H., Int. J. Cancer (Pred. Oncol.), 2001, vol. 95, pp. 108–113.

    Article  CAS  Google Scholar 

  44. Park, W.S., Oh, R.R., Park, J.Y., Lee, S.H., Shin, M.S., Kim, Y.S., Kim, S.Y., Lee, H.K., Kim, P.J., Oh, S.T., Yoo, N.J., and Lee, J.Y., Cancer Res., 1999, vol. 59, pp. 4257–4260.

    CAS  Google Scholar 

  45. Werner, M., Becker, K.F., Keller, G., and Hoefler, H.J., Cancer Res. Clin. Oncol., 2001, vol. 127, pp. 207–216.

    Article  CAS  Google Scholar 

  46. Lee, S.H., Lee, J.W., Soung, Y.H., Kim, H.S., Park, W.S., Kim, S.Y., Lee, J.H., Park, J.Y., Cho, Y.G., Kim, C.J., Nam, S.W., Kim, S.H., Lee, J.Y., and Yoo, N.J., Oncogene, 2003, vol. 22, pp. 6942–6945.

    Article  CAS  Google Scholar 

  47. Kimura, K., Nagasaka, T., Hoshizima, N., Sasamoto, H., Notohara, K., Takeda, M., Kominami, K., Iishii, T., Tanaka, N., and Matsubara, N., J. Intern. Med. Res., 2007, vol. 35, pp. 450–457.

    CAS  Google Scholar 

  48. Fleischhacker, M. and Schmidt, B., Biochim. Biophys. Acta, 2007, vol. 1775, pp. 181–232.

    CAS  Google Scholar 

  49. Arber, N., Shapira, I., Ratan, J., Stern, B., Hibshoosh, H., Moshkowitz, M., Gammon, M., Fabian, I., and Halpern, Z., Gastrienterology, 2000, vol. 118, pp. 1045–1050.

    Article  CAS  Google Scholar 

  50. Hiyama, T., Haruma, K., Kitadai, Y., Masuda, H., Miyamoto, M., Tanaka, S., Yoshihara, M., Shimamoto, F., and Chayama, K., Int. J. Cancer, 2002, vol. 97, pp. 562–566.

    Article  CAS  Google Scholar 

  51. Kim, I.-J., Park, J.-H., Kang, H.C., Shin, Y., Park, H.-W., Park, H.-R., Ku, J.-L., Lim, S.-B., and Park, J.-G., Hum. Genet., 2003, vol. 114, pp. 118–120.

    Article  CAS  Google Scholar 

  52. Wu, M., Semba, S., Oue, N., Ikehara, N., Yasui, W., and Yokozaki, H., Gastric Cancer, 2004, vol. 7, pp. 246–253.

    Article  CAS  Google Scholar 

  53. Jeong, E.G., Lee, S.H., Kim, S.S., Ahn, C.H., Yoo, N.J., and Lee, S.H., APMIS, 2007, vol. 115, pp. 976–981.

    Article  CAS  Google Scholar 

  54. Song, J.H., Kim, C.J., Cho, Y.G., Kwak, H.J., Nam, S.W., Yoo, N.J., Lee, J.Y., and Park, W.S., APMIS, 2007, vol. 115, pp. 802–808.

    Article  Google Scholar 

  55. Sasao, S., Hiyama, T., Tanaka, S., Yoshihara, M., Yasui, W., and Chayama, K., Oncology Reports, 2006, vol. 16, pp. 11–15.

    CAS  Google Scholar 

  56. Rubtsov, N.B., Metody raboty s khromosomami mlekopitayushchikh (Methods for Work with Mammalian Chromosomes), Novosibirsk: Novosibirsk State University Press, 2006.

    Google Scholar 

  57. Gorringe, K.L., Boussioutas, A., and Bowtell, D.D.L., Genes, Chromosomes, and Cancer, 2005, vol. 45, pp. 247–259.

    Article  CAS  Google Scholar 

  58. Kang, J.U., Kang, J.J., Kwon, K.C., Park, J.W., Jeong, T.E., Noh, S.M., and Koo, S.H., J. Korean Med. Sci., 2006, vol. 21, pp. 656–665.

    Article  CAS  Google Scholar 

  59. Kimura, Y., Noguchi, T., Kawahara, K., Kashima, K., Daa, T., and Yokoyama, S., Modern Pathology, 2004, vol. 17, pp. 1328–1337.

    Article  CAS  Google Scholar 

  60. Weiss, M.M., Kuipers, E.J., Postma, C., Snijders, A.M., Pinkel, D., Meuwisswn, S.G.M., Albertson, D., and Meijer, G.A., Cellular Oncology, 2004, vol. 26, pp. 307–317.

    CAS  Google Scholar 

  61. Vauhkonen, H., Vauhkonen, M., Sajantila, A., Sipponen, P., and Knuutila, S., Cancer Genet. Cytogenet., 2006, vol. 167, pp. 150–154.

    Article  CAS  Google Scholar 

  62. Qi, W., Baiqiu, W., Xinyuan, G., Hui, G., Hui, C., Qifan, Z., Chengbin, H., Pu, L., and Songbin, F., Chin. Med. J., 2003, vol. 116(4), pp. 517–523.

    Google Scholar 

  63. Buffart, T.E., Carvalho, B., Hopmans, E., Brehm, V., Kranenbarg, E.K., Schaaij-Visser, T.B.M., Eijk, P.P., van Grieken, N.C.T., Ylstra, B., van de Velde, C.J.H., and Meijer, G.A., J. Pathol., 2007, vol. 211, pp. 54–51.

    Article  CAS  Google Scholar 

  64. Baffa, R., Santoro, R., Bullrich, F., Mandes, B., Ishii, H., and Croce, C.M., Clin. Cancer Res., 2000, vol. 6, pp. 1372–1377.

    CAS  Google Scholar 

  65. Knudson, A.G., Nature Reviews, 2001, vol. 1, pp. 157–162.

    Article  CAS  Google Scholar 

  66. Fringes, B., Mayhew, T.M., Reith, A., Gates, J., and Ward, D.C., Lab. Invest., 2000, vol. 80, pp. 1501–1508.

    CAS  Google Scholar 

  67. Hosseini, H.A., Ahani, A., Galehdari, H., Froughmand, A.M., Hosseini, M., Masjedizadeh, A., and Zali, M.R., World J. Gastroenterol., 2007, vol. 13, pp. 3354–3358.

    CAS  Google Scholar 

  68. Kim, H.C., Kim, J.C., Roh, S.A., Yu, C.S., Yook, J.H., Oh, S.T., Kim, B.S., Park, K.C., and Chang, R.J., Cancer Res. Clin. Oncol., 2005, vol. 131, pp. 733–740.

    Article  CAS  Google Scholar 

  69. Yasui, W., Oue, N., Kuniyasu, H., Ito, R., Tahara, E., and Yokozaki, H., Gastric Cancer, 2001, vol. 4, pp. 113–121.

    Article  CAS  Google Scholar 

  70. Strand, M., Prolla, T.A., Liskay, R.M., and Petes, T.D., Nature, 1993, vol. 365, pp. 274–276.

    Article  CAS  Google Scholar 

  71. Suzuki, H., Itoh, F., Toyota, M., Kikuchi, T., Kakiuchi, H., Hinoda, Y., and Imai, K., Int. J. Cancer, 1999, vol. 83, pp. 309–313.

    Article  CAS  Google Scholar 

  72. An, C., Choi, I.-S., Yao, J.C., Worah, S., Xie, K., Mansfield, P.F., Ajani, J.A., Rashid, A., Hamilton, S.R., and Wu, T.-T., Clin. Cancer Res., 2005, vol. 11, pp. 656–663.

    CAS  Google Scholar 

  73. Carvalho, B., Pinto, M., Cirnes, L., Oliveira, C., Machado, J.C., Suriano, G., Hamelin, R., Carneiro, F., and Seruca, R., Eur. J. Cancer, 2003, vol. 39, pp. 1222–1227.

    Article  CAS  Google Scholar 

  74. Lee, H.S., Choi, S.I., Lee, H.K., Kim, H.S., Yang, H.-K., Kang, G.H., Kim, Y.I., Lee, B.L., and Kim, W.H., Mod. Pathol., 2002, vol. 15, pp. 632–640.

    Article  Google Scholar 

  75. Greenman, N., Stephens, P., Smith, R., Dalgliesh, G.L., Hunter, C., Bignell, G., Davies, H., Teague, J., Butler, A., Stevens, C., Edkins, S., et al., Nature, 2007, vol. 446, pp. 153–158.

    Article  CAS  Google Scholar 

  76. Sjoblom, T., Jones, S., Wood, L.D., Parsons, D.W., Lin, J., Barber, T.D., Mandelker, D., Lin, J., Leary, R.J., Ptak, J., Silliman, N., Szabo, S., Buckhauits, P., Farrell, C., et al., Science, 2006, vol. 314, pp. 268–274.

    Article  CAS  Google Scholar 

  77. Esteller, M., Ann. Rev. Pharmacol. Toxicol., 2005, vol. 45, pp. 629–656.

    Article  CAS  Google Scholar 

  78. Herman, J.G., Graff, J.R., Myoehaenen, S., Nelkin, B.D., and Baylin, S.B., Proc. Natl. Acad. Sci.USA, 1996, vol. 93, pp. 9821–9826.

    Article  CAS  Google Scholar 

  79. Herman, J.G., Semin. Cancer Biol., 1999, vol. 9, pp. 359–367.

    Article  CAS  Google Scholar 

  80. Choi, I.-S. and Wu, T.-T., Cell Res., 2005, vol. 15, pp. 247–254.

    Article  CAS  Google Scholar 

  81. Likhtenshtein, A.V. and Kiseleva, N.P., Biochemistry (Moscow), 2001, vol. 66, pp. 293–317.

    Google Scholar 

  82. To, K.-F., Leung, W.K., Lee, T.-L., Yu, J., Tong, J.H.M., Chan, M.W.Y., Ng, E.K.W., Chung, S.C.S., and Sung, J.J.Y., Int. J. Cancer, 2002, vol. 102, pp. 623–628.

    Article  CAS  Google Scholar 

  83. Hou, P., Ji, M.-J., Shen, J.-Y., He, N.-Y., and Lu, Z.-H., Biochemical Genet., 2005, vol. 43, pp. 1–9.

    Article  CAS  Google Scholar 

  84. Lee, T.-L., Leung, W.K., Chan, M.W.Y., Ng, E.K.W., Tong, J.H.M., Lo, K.-W, Chung, S.C.S., Sung, J.J.Y., and To, K-F., Clin. Cancer Res., 2002, vol. 8, pp. 1761–1766.

    CAS  Google Scholar 

  85. Lee, J.-H., Park, S.-J., Abraham, S.C., Seo, J.-S., Nam, J.-H., Choi, C., Juhng, S.-W., Rashid, A., Hamilton, S.R, and Wu, T.-T., Oncogene, 2004, vol. 23, pp. 4646–4654.

    Article  CAS  Google Scholar 

  86. Leung, W.K., To, K.-F., Chu, E.S.H., Chan, M.W.Y., Bai, A.H.C., Ng, E.K.W., Chan, F.K.L., and Sung, J.J.Y., Brit. J. Cancer, 2005, vol. 92, pp. 2190–2194.

    Article  CAS  Google Scholar 

  87. Leung, W.K., Yu, J., Ng, E.K.W., To, K.F., Ma, P.K., Lee, T.L., Go, M.Y.Y., Chung, S.C.S., and Sung, J.J.Y., Cancer, 2001, vol. 91, pp. 2294–2301.

    Article  CAS  Google Scholar 

  88. Kang, G.H., Lee, S., Kim, J.-S., and Jung, H.-Y., Laboratory Investigation, 2003, vol. 83, pp. 635–641.

    CAS  Google Scholar 

  89. Kang, G.H., Lee, H.J., Hwang, K.S., and Lee, S., Am. J. Pathol., 2003, vol. 163, pp. 1551–1556.

    CAS  Google Scholar 

  90. Kang, G.H., Shim, Y.-H., Jung, H.-Y., Kim, W.H., Ro, J.Y., and Rhyu, M.-G., Cancer Res., 2001, vol. 61, pp. 2847–2851.

    CAS  Google Scholar 

  91. Koike, H., Ichikawa, D., Ikoma, H., Otsuji, E., Kitamura, K., and Yamagishi, H., J. Surgical Oncology, 2004, vol. 87, pp. 182–186.

    Article  CAS  Google Scholar 

  92. Sato, F. and Meltzer, S.J., Cancer, 2006, vol. 106, pp. 483–493.

    Article  CAS  Google Scholar 

  93. Oue, N., Oshimo, Y., Nakayama, H., Ito, R., Yoshida, K., Matsusaki, K., and Yasui, W., Cancer Sci., 2003, vol. 94, pp. 901–905.

    Article  CAS  Google Scholar 

  94. Sarbia, M., Geddert, H., Klump, B., Kiel, S., Iskender, E., and Gabbert, H.E., Int. J. Cancer, 2004, vol. 111, pp. 224–228.

    Article  CAS  Google Scholar 

  95. Waki, T., Tamura, G., Tsuchiya, T., Sato, K., Nishizuka, S., and Motoyama, T., Am. J. Pathol., 2002, vol. 161, pp. 399–403.

    CAS  Google Scholar 

  96. Paz, M.F., Fraga, M.F., Avila, S., Guo, M., Pollan, M., Herman, J.G., and Esteller, M., Cancer Res., 2003, vol. 63, pp. 1114–1121.

    CAS  Google Scholar 

  97. Waki, T., Tamura, G., Sato, M., and Motoyama, T., Oncogene, 2003, vol. 22, pp. 4128–4133.

    Article  CAS  Google Scholar 

  98. Song, S.H., Jong, H.-S., Choi, H.H., Inoue, H., Tanabe, T., Kim, N.K., and Bang, Y.-J., Cancer Res., 2001, vol. 61, pp. 4628–4635.

    CAS  Google Scholar 

  99. Kikuchi, T., Itoh, F., Toyota, M., Suzuki, H., Yamamoto, H., Fujita, M., Hosokawa, M., and Imai, K., Int. J. Cancer, 2002, vol. 97, pp. 272–277.

    Article  CAS  Google Scholar 

  100. Donninger, H., Vos, M.D., and Clark, G.J., J. Cell Sci., 2007, vol. 120, pp. 3163–3172.

    Article  CAS  Google Scholar 

  101. Oue, N., Shigeishi, H., Kuniyasu, H., Yokozaki, H., Kurauka, K., Ito, R., and Yasui, W., Int. J. Cancer, 2001, vol. 93, pp. 805–809.

    Article  CAS  Google Scholar 

  102. Esteller, M., Hamilton, S.R., Burger, P.C., Baylin, S.B., and Herman, J.G., Cancer Res., 1999, vol. 59, pp. 793–797.

    CAS  Google Scholar 

  103. Oue, N., Sentani, K., Yokozaki, H., Kitadai, Y., Ito, R., and Yasui, W., Pathobiology, 2001, vol. 69, pp. 143–149.

    Article  CAS  Google Scholar 

  104. Hong, S. H., Kim, H.G., Chung, W.B., Kim, E.Y., Lee, J.Y., Yoon, S.M., Kwon, J.G., Sohn, Y.K., Kwak, E.K., and Kim, J.W., J. Korean Med. Sci., 2005, vol. 20, pp. 236–241.

    Article  CAS  Google Scholar 

  105. Park, T.J., Han, S.-U., Cho, Y.-K., Paik, W.K., Kim, Y.B., and Lim, I.K., Cancer, 2001, vol. 92, pp. 2760–2768.

    Article  CAS  Google Scholar 

  106. Geddert, H., Kiel, S., Iskander, E., Florl, A.R., Krieg, T., Vossen, S., Gabbert, H.E., and Sarbia, M., Int. J. Cancer, 2004, vol. 110, pp. 208–211.

    Article  CAS  Google Scholar 

  107. Bryzgunova, O.E., Vlasov, V.V., and Laktionov, P.P., Biomed. Khim., 2007, vol. 53, pp. 128–139.

    CAS  Google Scholar 

  108. Kang, S.H., Choi, H.H., Kim, S.G., Jong, H.-S., Kim, N.K., Kim, S.-J., and Bang, Y.-J., Int. J. Cancer, 2000, vol. 86, pp. 632–635.

    Article  CAS  Google Scholar 

  109. McCawley, L.J. and Matrisian, L.M., Molecular Medicine Today, 2000, vol. 60, pp. 149–156.

    Article  Google Scholar 

  110. Raveh, T. and Kimichi, A., Exper.Cell Res., 2001, vol. 264, pp. 185–192.

    Article  CAS  Google Scholar 

  111. Chan, A.W.H., Chan, M.W.Y., Lee, T-L., Ng, E.K.W., Leung, W.-K., Lau, J.Y.W., Tong, J.H.M., Chan, F.K.L., and To, K.-F., Oncol. Reports, 2005, vol. 13, pp. 937–941.

    CAS  Google Scholar 

  112. Waki, T., Tamura, G., Sato, M., Terashima, M., Nishizuka, S., and Motoyama, T., Cancer Sci., 2003, vol. 94, pp. 360–364.

    Article  CAS  Google Scholar 

  113. Graziano, F., Arduini, F., Ruzzo, A., Bearzi, I., Humar, B., More, H., Silva, R., Muretto, P., Guilford, P., Testa, E., Mari, D., Magnani, M., and Cascinu, S., Clin. Cancer Res., 2004, vol. 10, pp. 2784–2789.

    Article  CAS  Google Scholar 

  114. Graziano, F., Arduini, F., Ruzzo, A., Mandolesi, A., Bearzi, I., Silva, R., Muretto, P., Testa, P.E., Mari, D., Magnani, M., Scartozzi, M., and Cascinu, S., Ann. Oncol., 2004, vol. 15, pp. 489–492.

    Article  CAS  Google Scholar 

  115. Ren, B., Yee, K.O., Lawler, J., and Khosravi-Far, R., Biochim. Biophys. Acta, 2006, vol. 1765, pp. 178–188.

    CAS  Google Scholar 

  116. Virmani, A.K., Rathi, A., Zöchbauer-Müller, S., Sacchi, N., Fukuyama, Y., Bryant, D., Maitra, A., Heda, S., Fong, K.M., Thunnissen, F., Minna, J.D., and Gazdar, A.F., J. Natl. Cancer Inst., 2000, vol. 92, pp. 1303–1307.

    Article  CAS  Google Scholar 

  117. Anker, P., Mulcahy, H., and Stroun, M., Int. J. Cancer, 2003, vol. 103, pp. 149–152.

    Article  CAS  Google Scholar 

  118. Kanyama, Y., Hibi, K., Nakayama, H., Kodera, Y., Ito, K., Akiyama, S., and Nakao, A., Cancer Sci., 2003, vol. 94, pp. 418–420.

    Article  CAS  Google Scholar 

  119. Tamkovich, S.N., Bryzgunova, O.E., Rykova, E.Y., Permyakova, V.I., Vlassov, V.V., and Laktionov, P.P., Clin. Chem., 2005, vol. 51, pp. 1317–1319.

    Article  CAS  Google Scholar 

  120. Rykova, E.Y., Skvortsova, T.E., Laktionov, P.P., Tamkovich, S.N., Bryzgunova, O.E., Starikov, A.V., Kuznetsova, N.P., Kolomiets, S.A., Sevostianova, N.V., and Vlassov, V.V., Nucleosides, Nucleotides, Nucleic Acids, 2004, vol. 23, pp. 855–859.

    Article  CAS  Google Scholar 

  121. Skvortsova, T.E., Rykova, E.Y., Tankovich, S.N., Pryzgunova, O.E., Starikov, A.V., Kuznetsova, N.P., Vlassov, V.V., and Laktionov, P.P., Brit. J. Cancer, 2006, vol. 94, pp. 1492–1495.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, pr. Lavrent’eva 8, Novosibirsk, 630090, Russia

    E. V. Elistratova, P. P. Laktionov, V. V. Vlassov & E. Y. Rykova

  2. Novosibirsk Oncological Dispensary, ul. Plachotnogo 2, Novosibirsk, 630108, Russia

    P. I. Shelestuk

  3. Cancer Research Institute, Siberian Branch, Russian Academy of Medical Sciences, per. Kooperativnyi 5, Tomsk, 634009, Russia

    S. A. Tuzikov

Authors
  1. E. V. Elistratova
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  2. P. P. Laktionov
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  3. P. I. Shelestuk
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  4. S. A. Tuzikov
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  5. V. V. Vlassov
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  6. E. Y. Rykova
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Correspondence to E. V. Elistratova.

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Original Russian Text © E.V. Elistratova, P.P. Laktionov, P.I. Shelestuk, S.A. Tuzikov, V.V. Vlassov, E.Y. Rykova, 2009, published in Biomeditsinskaya Khimiya.

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Elistratova, E.V., Laktionov, P.P., Shelestuk, P.I. et al. Immunochemical and molecular-Genetic markers in diagnostics of gastric cancer. Biochem. Moscow Suppl. Ser. B 3, 33–43 (2009). https://doi.org/10.1134/S1990750809010041

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  • DOI: https://doi.org/10.1134/S1990750809010041

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