Abstract
Proteomic technologies revealed products of 2 genes (α-actin and albumin) in a human myocardium tissue. They exist as fragments and their appearance and increased content correlated with age. The age-related variants differ from the mature forms of these proteins by the absence of N-terminal fragments of the amino acid sequences. In the chronic ischemic heart disease (CIHD), these age-related proteins were found in 50% of cases (in the age group 31–40 years), whereas in the control group such combination was detected only in 10% of the examined individuals. Subsequent studies in this field would probably reveal molecular mechanisms responsible for impairment and/or ageing of the myocardium and also of adaptation/disadaptation mechanisms in the CIHD.
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Original Russian Text © M.A. Kovalyova, L.I. Kovalyov, M.V. Serebryakova, S.A. Moshkovskii, S.S. Shishkin, 2008, published in Biomeditsinskaya Khimiya.
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Kovalyova, M.A., Kovalyov, L.I., Serebryakova, M.V. et al. Age-related changes in albumin and actin of human myocardium. Biochem. Moscow Suppl. Ser. B 2, 160–165 (2008). https://doi.org/10.1134/S1990750808020054
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DOI: https://doi.org/10.1134/S1990750808020054