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The use of SNP markers for estimation of individual genetic predisposition to diabetes mellitus type 1 and 2

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Abstract

Single nucleotide polymorphisms (SNPs) are now considered as the most perspective and convenient markers for studies of genetic basis of multifactorial diseases. Fast development of technologies for exact screening of a large volume of genetic information and construction of genomic maps of SNP-markers promote the development of innovative diagnostic systems on the basis of significant SNP for an estimation of individual genetic risk of development of various diseases. This review considers the basic aspects of genetics of diabetes mellitus type 1 and 2 and an opportunity to use SNP as markers for the estimation of individual genetic predisposition to this disease.

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  1. Institute of Biomedical Chemistry, Russian Academy of Medical Science, ul. Pogodinskaya 10, Moscow, 119121, Russia

    O. E. Voronko, N. V. Bodoev & A. I. Archakov

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  1. O. E. Voronko
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  2. N. V. Bodoev
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Original Russian Text © O.E. Voronko, N.V. Bodoev, A.I. Archakov, 2008, published in Biomeditsinskaya Khimiya.

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Voronko, O.E., Bodoev, N.V. & Archakov, A.I. The use of SNP markers for estimation of individual genetic predisposition to diabetes mellitus type 1 and 2. Biochem. Moscow Suppl. Ser. B 2, 126–132 (2008). https://doi.org/10.1134/S1990750808020029

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