Abstract
The effect of recombinant LIF cytokine (Leukemia inhibitory factor) on the isolated mouse embryos at the stages of middle and late blastocyst has been investigated. We have demonstrated here that this agent is necessary in vitro at the stage of normal trophoblast formation after the blastocysts hatch from zona pellucida. This cytokine (10 ng/ml) caused intensification of adhesion and proliferative activity of the trophoblast cells. This is important for intercellular interactions with endometrium and for invasion of embryos into the uterus. The recombinant LIF insignificantly influenced cells of the inner cell mass.
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Original Russian Text © L.M. Mezhevikina, I.V. Kapralova, E.E. Fesenko, 2007, published in Biomeditsinskaya Khimiya.
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Mezhevikina, L.M., Kapralova, I.V. & Fesenko, E.E. The stimulating effect of recombinant cytokine LIF on the mouse blastocysts during implantation. Biochem. Moscow Suppl. Ser. B 1, 164–167 (2007). https://doi.org/10.1134/S1990750807020102
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DOI: https://doi.org/10.1134/S1990750807020102