Abstract
Carnosine administration (in a daily dose of 2 g) as an additional therapy for patients with chronic discirculatory encephalopathy (DE) results in an increase in stability of blood plasma lipoproteins toward Fe2+-induced oxidation and stabilization of red blood cells against acidic hemolysis as well as intensification of respiratory burst of periphery blood leucocytes. At the same time, latent period of brain induced potentials, P300, decreases and the proportion of the high-amplitude induced potentials increases. The data presented demonstrate that carnosine enhances the efficiency of basal therapy of DE patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Gulevitshch, W.S. and Amiradgibi, S., Uber das Carnosin, eine Neue Organische Base des Flieischextractes, Ber. Deutsch. Chem. Ges., 1900, vol. 33, pp. 1902–1903.
Boldyrev, A.A., Karnozin i zashchita tkanei ot okislitel’nogo stressa (Carnosine and Protection of Tissues against Oxidative Stress), Moscow, Dialog-Moscow State University, 1999.
Boldyrev, A. Carnosine and Oxidative Stress in Cells and Tissues, N.-Y., Nova Publishers, 2006.
Vereshchagin, N.V., Tanashyan, M.M., Fedorova, T.N., and Smirnova, I.N., Antioxidants in Angioneurology, Atmosphere. Neuronal Diseases (Rus.), 2004, no. 3, pp. 8–12.
Suslina, Z.A., Fedorova, T.N., Maximova, M.Yu., Ryasina, T.V., Stvolinsky, S.L., Khrapova, E.V., and Boldyrev, A.A., Antioxidant Therapy under Ischemic Stroke, Zhurnal Neurologii i Psykhiatrii (Rus.), 2000, vol. 100, no. 10, pp. 34–38.
Fedorova, T.N., Bagyeva, G.Kh., Stepanova, M.S., Dobrotvorskaya, I.C., Ivanova-Smolenskaya, I.A., Polevaya, E.V., Boldyrev, A.A., and Illarioshkin, S.N., Carnosine Increases Efficiency of Drug Therapy at Parkinson Disease, Bekhterev Neurol. Byull. (Rus.), 2008 (in press).
Arzumanyan, E.S., Makhro, A.V., Tyulina, O.V., and Boldyrev, A.A., Carnosine Protects Erythrocytes from the Oxidative Stress Caused by Homocysteic Acid, Dokl. RAN, Biochem. Biophys. (Rus.), 2008, vol. 418, pp. 44–46.
Stvolinsky, S.L., Sousa-Pontesh, E., Sergienko, V.I., and Boldyrev, A.A., Immune Modulating Effects of Carnosine in Experiments in Vitro and in Vivo, Biol. Membr. (Rus.), 1996, vol. 13, pp. 299–306.
Gnezditsky, V.V., Vyzvannye potentsialy mozga v klinicheskoi praktike (Brain Induced Potentials in Clinical Practice), Moscow, MED Press-Inform, 2003.
Makhro, A.V., Mashkina, A.P., Solenaya, O.A., Trunova, O.A., Tyulina, O.V., Bulygina, E.R., and Boldyrev, A.A., Carnosine Protects from Oxidative Stress Induced by Hyperhomocysteinemia, Neurokhimia (Rus.), 2008, vol. 25, pp. 233–240.
Severin, S.E., Discovery of Carnosine and Anserine. Some Features, Biokhimia (Moscow) (Rus.), 1992, vol. 57, pp. 1285–1295.
Zenkov, N.K., Lankin, V.Z., and Menjshikova, E.B., Okislitel’nyi stress. Biokhimicheskie I patofiziologicheskie aspekty (Oxidative Stress. Biochemical and Patophysiological Aspects), Moscow, MAIK (Nauka/Interperiodika), 2001.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © T.N. Fedorova, M.S. Belyaev, O.A. Trunova, V.V. Gnezditsky, M.Yu. Maximova, A.A. Boldyrev, 2008, published in Biologicheskie Membrany, 2008, Vol. 25, No. 6, pp. 458–462.
Rights and permissions
About this article
Cite this article
Fedorova, T.N., Belyaev, M.S., Trunova, O.A. et al. Neuropeptide carnosine increases stability of lipoproteins and red blood cells as well as efficiency of immune competent system in patients with chronic discirculatory encephalopathy. Biochem. Moscow Suppl. Ser. A 3, 62–65 (2009). https://doi.org/10.1134/S1990747809010085
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1990747809010085