Cell and Tissue Biology

, Volume 12, Issue 3, pp 247–255 | Cite as

Bioresorption of Porous 3D Matrices Based on Collagen in Liver and Muscular Tissue

  • P. V. PopryadukhinEmail author
  • G. Y. Yukina
  • I. P. Dobrovolskaya
  • E. M. Ivankova
  • V. E. Yudin


Highly porous cylinder-shaped 3D matrices with diameters of 1.3 and 3 mm were obtained by lyophilization of collagen solution. A study in vivo of the mechanism and rate of resorption of the resulting material showed that complete resorption of the matrix occurred 6 weeks after their implantation into liver tissue and 3 weeks after implantation into muscle tissue of animals. Surrounding tissues were not altered or damaged. Histological analysis revealed that, simultaneously with the resorption of matrix collagen, connective tissue and blood vessels were formed. This allows us to recommend the developed porous material based on collagen for use as matrices for tissue engineering and cellular transplantation.


3D porous material collagen resorption tissue engineering cellular transplantation liver muscle tissue histological analysis 



porous collagen matrix


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • P. V. Popryadukhin
    • 1
    Email author
  • G. Y. Yukina
    • 2
  • I. P. Dobrovolskaya
    • 3
  • E. M. Ivankova
    • 1
  • V. E. Yudin
    • 3
  1. 1.Institute of Macromolecular CompoundsRussian Academy of SciencesSt. PetersburgRussia
  2. 2.Pavlov First St. Petersburg State Medical UniversitySt. PetersburgRussia
  3. 3.Peter the Great St. Petersburg Polytechnic UniversitySt. PetersburgRussia

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