Cell and Tissue Biology

, Volume 12, Issue 2, pp 127–134 | Cite as

Changes in the Architectonics and Morphometric Characteristics of Erythocytes under the Influence of Magnetite Nanoparticles

  • S. N. Pleskova
  • E. E. Gornostaeva
  • R. N. Kryukov
  • A. V. Boryakov
  • S. Yu. Zubkov


A new high-precision technique for calculating the ratio of the erythrocyte area/volume using atomic-force microscopy has been developed. The method was tested on erythrocytes of healthy donors. Scanning electron microscopy, atomic-force microscopy, and X-ray microanalysis revealed that magnetite nanoparticles can interact with erythrocyte membranes in vitro. This interaction resulted in the development of a pathology of erythrocytes typical for poikilocytosis and anisocytosis. When the magnetite was incubated with erythrocytes in a serum-free medium, nanoparticles aggregated.


erythrocytes area/volume ratio magnetite nanoparticles archytectonics atomic-force microscopy scanning electron microscopy X-ray microanalysis 



atomic-force microscopy


magnetite nanoparticles


scanning electron microscopy


phosphate buffer saline


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • S. N. Pleskova
    • 1
  • E. E. Gornostaeva
    • 2
  • R. N. Kryukov
    • 1
  • A. V. Boryakov
    • 2
  • S. Yu. Zubkov
    • 1
  1. 1.Research and Education Center Physics for Solid State NanostructuresNizhny Novgorod State UniversityNizhny NovgorodRussia
  2. 2.New Materials and Resource-Saving Technologies Center of Collective Use of the Scientific Research Institute of Chemistry of Nizhny Novgorod State UniversityNizhny NovgorodRussia

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