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Lysophosphatidic acid and human erythrocyte aggregation

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Abstract

The effect of lysophosphatidic acid (LPA) on the shape and aggregation of human erythrocytes in autologous plasma was studied. The morphology of erythrocytes and their aggregates were studied by light microscopy. It is shown that the addition of plasma with a high LPA content to erythrocytes leads to a change of their shape: discocytes are transformed into echinocytes. There is practically no aggregation of erythrocytes in the form of rouleaux. At the same time, there is observed a strong aggregation of echinocytes. This is accompanied by the formation of microvesicles. The addition of normal blood plasma to echinocytes restores their shape and aggregation of red blood cells in the form of rouleaux. A possible mechanism of action of lysophosphatidic acid on erythrocytes is discussed.

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Authors and Affiliations

  1. Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Nizhni Novgorod, Russia

    Yu. A. Sheremet’ev, A. N. Popovicheva & G. Ya. Levin

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  1. Yu. A. Sheremet’ev
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  2. A. N. Popovicheva
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  3. G. Ya. Levin
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Correspondence to Yu. A. Sheremet’ev.

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Original Russian Text © Yu.A. Sheremet’ev, A.N. Popovicheva, G.Ya. Levin, 2014, published in Tsitologiya, 2014, Vol. 56, No. 1, pp. 84–88.

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Sheremet’ev, Y.A., Popovicheva, A.N. & Levin, G.Y. Lysophosphatidic acid and human erythrocyte aggregation. Cell Tiss. Biol. 8, 237–243 (2014). https://doi.org/10.1134/S1990519X14030110

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