Abstract
Changes in cell area during CHO cell cultivation have been studied with time-lapse microscopy. Capture was started the day after cell plating. It was found that the size of daughter cells after mitosis remained less than the size of the mother cell for a long time (up to 6 h). Nevertheless, the average cell area of the whole population was constant during the observation period (up to 18 h). We assume that this phenomenon is a result of interaction between dividing and nondividing cells. The experimental data we obtained confirm this conclusion.
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Petrov, Y.P., Negulyaev, Y.A. Average cell size is a factor reflecting the interaction of CHO cells during their proliferation. Cell Tiss. Biol. 5, 595–602 (2011). https://doi.org/10.1134/S1990519X11060113
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DOI: https://doi.org/10.1134/S1990519X11060113