Abstract
For block-linear dynamical systems of dimensions 3 and 4 considered as models of simplest circular gene networks, we find sufficient conditions for the existence of invariant surfaces in their phase portraits. These surfaces contain periodic trajectories of the dynamical systems.
REFERENCES
L. Glass and J. S. Pasternack, “Stable oscillations in mathematical models of biological control systems,” J. Math. Biology. 6, 207–223 (1978).
Systems Computational Biology (Izd. Sib. Otd. Ross. Akad. Nauk, Novosibirsk, 2008) [in Russian].
V. A. Likhoshvai, V. P. Golubyatnikov, and T. M. Khlebodarova, “Limit cycles in models of circular gene networks regulated by negative feedback loops,” BMC Bioinf. 21 (11), 255– (2020). https://doi.org/10.1186/s12859-020-03598-z
V. P. Golubyatnikov, V. V. Ivanov, and L. S. Minushkina, “On the existence of a cycle in one nonsymmetric model of a circular gene network,” Sib. Zh. Chist. Prikl. Mat. 18 (3), 26–32 (2018).
V. P. Golubyatnikov and V. V. Ivanov, “Uniqueness and stability of a cycle in three-dimensional block-linear models of circular gene networks,” Sib. Zh. Chist. Prikl. Mat. 18 (4), 19–28 (2018).
E. P. Volokitin, “On limit cycles in the simplest model of a hypothetical gene network,” Sib. Zh. Ind. Mat. 7 (3), 57–65 (2004).
N. B. Ayupova and V. P. Golubyatnikov, “On the uniqueness of a cycle in an asymmetric three-dimensional model of a molecular repressilator,” Sib. Zh. Ind. Mat. 17 (1), 3–7 (2014) [J. Appl. Ind. Math. 8 (2), 153–157 (2014)].
V. P. Golubyatnikov and L. S. Minushkina, “Monotonicity of the Poincaré mapping in some models of circular gene networks,” Sib. Zh. Ind. Mat. 22 (3), 39–47 (2019) [J. Appl. Ind. Math. 13 (3), 472–479 (2019)].
S. Hastings, J. Tyson, and D. Webster, “Existence of periodic solutions for negative feedback cellular control systems,” J. Differ. Equat. 25, 39–64 (1977).
V. P. Golubyatnikov and L. S. Minushkina, “On uniqueness and stability of a cycle in one gene network,” Sib. Electron. Math. Rep. 18 (1), 464–473 (2021).
N. B. Ayupova and V. P. Golubyatnikov, “On a cycle in a 5-dimensional circular gene network model,” Sib. Zh. Ind. Mat. 24 (3), 19–29 (2021) [J. Appl. Ind. Math. 15 (3), 376–383 (2021)].
N. E. Kirillova, “On invariant surfaces in gene network models,” Sib. Zh. Ind. Mat. 23 (4), 69–76 (2020) [J. Appl. Ind. Math. 14 (4), 666–671 (2020)].
V. V. Ivanov, “Attracting limit cycle of an odd-dimensional circular gene network model,” Sib. Zh. Ind. Mat. 25 (3), 25–32 (2022) [J. Appl. Ind. Math. 16 (3), 409–415 (2022)].
V. P. Golubyatnikov and V. V. Ivanov, “Cycles in the odd-dimensional models of circular gene networks,” Sib. Zh. Ind. Mat. 21 (4), 28–38 (2018) [J. Appl. Ind. Math. 12 (4), 648–657 (2018)].
P. Hartman, Ordinary Differential Equations (John Wiley & Sons, New York–London–Sydney, 1964; Mir, Moscow, 1970).
D. M. Grobman, “Topological classification of neighborhoods of a singular point in an \( n \)-dimensional space,” Mat Sb. 56 (1), 77–94 (1962).
R. M. Mints, “Investigation of some basic types of complex equilibrium states in three-dimensional space,” Mat. Sb. 63 (2), 169–214 (1964).
M. Hirsch, “Monotone dynamical systems with polyhedral order cones and dense periodic points,” AIMS Math. 2 (1), 24–27 (2017).
F. R. Gantmacher, Theory of Matrices (Nauka, Moscow, 1967; New York, Chelsea, 1959).
ACKNOWLEDGMENTS
The authors are sincerely grateful to S.A. Kantor for useful advice and discussions and also to the anonymous referee for critical remarks.
Funding
The work was carried out within the framework of the state order for the Sobolev Institute of Mathematics of the Siberian Branch of the Russian Academy of Sciences, project no. FWNF-2022-0009.
Author information
Authors and Affiliations
Corresponding authors
Additional information
Translated by V. Potapchouck
Rights and permissions
About this article
Cite this article
Ayupova, N.B., Golubyatnikov, V.P. & Minushkina, L.S. On Invariant Surfaces in the Phase Portraits of Models of Circular Gene Networks. J. Appl. Ind. Math. 16, 589–595 (2022). https://doi.org/10.1134/S1990478922040019
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1990478922040019