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On Invariant Surfaces in the Phase Portraits of Models of Circular Gene Networks

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Abstract

For block-linear dynamical systems of dimensions 3 and 4 considered as models of simplest circular gene networks, we find sufficient conditions for the existence of invariant surfaces in their phase portraits. These surfaces contain periodic trajectories of the dynamical systems.

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REFERENCES

  1. L. Glass and J. S. Pasternack, “Stable oscillations in mathematical models of biological control systems,” J. Math. Biology. 6, 207–223 (1978).

    Article  MathSciNet  MATH  Google Scholar 

  2. Systems Computational Biology (Izd. Sib. Otd. Ross. Akad. Nauk, Novosibirsk, 2008) [in Russian].

  3. V. A. Likhoshvai, V. P. Golubyatnikov, and T. M. Khlebodarova, “Limit cycles in models of circular gene networks regulated by negative feedback loops,” BMC Bioinf. 21 (11), 255– (2020). https://doi.org/10.1186/s12859-020-03598-z

  4. V. P. Golubyatnikov, V. V. Ivanov, and L. S. Minushkina, “On the existence of a cycle in one nonsymmetric model of a circular gene network,” Sib. Zh. Chist. Prikl. Mat. 18 (3), 26–32 (2018).

    MATH  Google Scholar 

  5. V. P. Golubyatnikov and V. V. Ivanov, “Uniqueness and stability of a cycle in three-dimensional block-linear models of circular gene networks,” Sib. Zh. Chist. Prikl. Mat. 18 (4), 19–28 (2018).

    Article  MathSciNet  MATH  Google Scholar 

  6. E. P. Volokitin, “On limit cycles in the simplest model of a hypothetical gene network,” Sib. Zh. Ind. Mat. 7 (3), 57–65 (2004).

    MathSciNet  MATH  Google Scholar 

  7. N. B. Ayupova and V. P. Golubyatnikov, “On the uniqueness of a cycle in an asymmetric three-dimensional model of a molecular repressilator,” Sib. Zh. Ind. Mat. 17 (1), 3–7 (2014) [J. Appl. Ind. Math. 8 (2), 153–157 (2014)].

    Article  MathSciNet  MATH  Google Scholar 

  8. V. P. Golubyatnikov and L. S. Minushkina, “Monotonicity of the Poincaré mapping in some models of circular gene networks,” Sib. Zh. Ind. Mat. 22 (3), 39–47 (2019) [J. Appl. Ind. Math. 13 (3), 472–479 (2019)].

    Article  MathSciNet  MATH  Google Scholar 

  9. S. Hastings, J. Tyson, and D. Webster, “Existence of periodic solutions for negative feedback cellular control systems,” J. Differ. Equat. 25, 39–64 (1977).

    Article  MathSciNet  MATH  Google Scholar 

  10. V. P. Golubyatnikov and L. S. Minushkina, “On uniqueness and stability of a cycle in one gene network,” Sib. Electron. Math. Rep. 18 (1), 464–473 (2021).

    MathSciNet  MATH  Google Scholar 

  11. N. B. Ayupova and V. P. Golubyatnikov, “On a cycle in a 5-dimensional circular gene network model,” Sib. Zh. Ind. Mat. 24 (3), 19–29 (2021) [J. Appl. Ind. Math. 15 (3), 376–383 (2021)].

    Article  MathSciNet  Google Scholar 

  12. N. E. Kirillova, “On invariant surfaces in gene network models,” Sib. Zh. Ind. Mat. 23 (4), 69–76 (2020) [J. Appl. Ind. Math. 14 (4), 666–671 (2020)].

    Article  MathSciNet  MATH  Google Scholar 

  13. V. V. Ivanov, “Attracting limit cycle of an odd-dimensional circular gene network model,” Sib. Zh. Ind. Mat. 25 (3), 25–32 (2022) [J. Appl. Ind. Math. 16 (3), 409–415 (2022)].

    Article  Google Scholar 

  14. V. P. Golubyatnikov and V. V. Ivanov, “Cycles in the odd-dimensional models of circular gene networks,” Sib. Zh. Ind. Mat. 21 (4), 28–38 (2018) [J. Appl. Ind. Math. 12 (4), 648–657 (2018)].

    Article  MathSciNet  MATH  Google Scholar 

  15. P. Hartman, Ordinary Differential Equations (John Wiley & Sons, New York–London–Sydney, 1964; Mir, Moscow, 1970).

    MATH  Google Scholar 

  16. D. M. Grobman, “Topological classification of neighborhoods of a singular point in an \( n \)-dimensional space,” Mat Sb. 56 (1), 77–94 (1962).

    MathSciNet  Google Scholar 

  17. R. M. Mints, “Investigation of some basic types of complex equilibrium states in three-dimensional space,” Mat. Sb. 63 (2), 169–214 (1964).

    MathSciNet  Google Scholar 

  18. M. Hirsch, “Monotone dynamical systems with polyhedral order cones and dense periodic points,” AIMS Math. 2 (1), 24–27 (2017).

    Article  MathSciNet  MATH  Google Scholar 

  19. F. R. Gantmacher, Theory of Matrices (Nauka, Moscow, 1967; New York, Chelsea, 1959).

    Google Scholar 

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ACKNOWLEDGMENTS

The authors are sincerely grateful to S.A. Kantor for useful advice and discussions and also to the anonymous referee for critical remarks.

Funding

The work was carried out within the framework of the state order for the Sobolev Institute of Mathematics of the Siberian Branch of the Russian Academy of Sciences, project no. FWNF-2022-0009.

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Correspondence to N. B. Ayupova, V. P. Golubyatnikov or L. S. Minushkina.

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Translated by V. Potapchouck

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Ayupova, N.B., Golubyatnikov, V.P. & Minushkina, L.S. On Invariant Surfaces in the Phase Portraits of Models of Circular Gene Networks. J. Appl. Ind. Math. 16, 589–595 (2022). https://doi.org/10.1134/S1990478922040019

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  • DOI: https://doi.org/10.1134/S1990478922040019

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