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Melancholic Depression Is Accompanied by Increased Level of Nerve Growth Factor in Blood Serum

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Abstract—The aim of the work was to study the level of nerve growth factor (NGF) in the serum of patients with melancholic depression. The examined group consisted of 23 patients. Upon admission to the clinic, before therapy began, the patients showed a significantly higher (278.28 pg/mL) level of NGF in the serum compared with control (239.51 ± 22.15) (p < 0.05). We believe that the increased level of NGF in serum in patients with melancholic depression may be associated with impaired functioning of the BBB and an increase in its permeability for neurotropic factor.

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Funding

The work was carried out within the framework of the scientific theme of the state task of The Serbsky State Scientific Center for Social and Forensic Psychiatry of the Ministry of Health of Russia “Development of Stationary and Dynamic Prognostic Markers for Affective spectrum disorders and schizoaffective disorder based on clinical pathogenetic, neurobiological, and psychopathological studies” 2021–2023. Registration number: 121041300179-3.

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Authors and Affiliations

  1. The Serbsky State Scientific Center for Social and Forensic Psychiatry, Moscow, Russia

    M. G. Uzbekov, S. N. Shikhov, V. V. Krjukov, V. V. Brilliantova & V. N. Krasnov

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  1. M. G. Uzbekov
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  2. S. N. Shikhov
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  3. V. V. Krjukov
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  4. V. V. Brilliantova
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  5. V. N. Krasnov
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Corresponding author

Correspondence to M. G. Uzbekov.

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ETHICS APPROVAL AND CONSENT TO PARTICIPATE

Ethical approval. The study was conducted in accordance with the Declaration of Helsinki on medical research involving humans and the conclusion of the local ethical committee of the Moscow Research Institute of Psychiatry (No. 16, 03.13.2017 and No. 41/2, 04.24.2023).

Informed consent. All diseased and healthy volunteers gave informed consent to participate in the study.

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The authors of this work declare that they have no conflicts of interest.

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Corresponding author; address: Poteshnaya ul. 3, Moscow, 107076 Russia; e-mail: uzbekovmg@gmail.com.

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Uzbekov, M.G., Shikhov, S.N., Krjukov, V.V. et al. Melancholic Depression Is Accompanied by Increased Level of Nerve Growth Factor in Blood Serum. Neurochem. J. 17, 755–757 (2023). https://doi.org/10.1134/S1819712423040232

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  • DOI: https://doi.org/10.1134/S1819712423040232

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