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Structure, Function and Distribution of ATP8A2 in Human and Mice

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Abstract

ATP8A2 can translocate phospholipids from exoplasmic to the cytoplasmic leaflets to establish and maintain the lipid asymmetry between the two leaflets. ATP8A2 has been recently reported due to the patients possessing severe neurological disorders with the mutated gene of ATP8A2, including cerebellar ataxia, mental retardation and dysequilibrium. In vivo experiments have identified the critical role of ATP8A2 in the nerve system of mice. In vitro experiments have shown the function of ATP8A2 in promoting the development of hippocampal neurons in rats together with CDC50A. Our previous research has focused on the presence and expression level of ATP8A2 in the prefrontal cortex of mice in neuroinflammation conditions and found that neonatal LPS exposure reduces ATP8A2 level in the prefrontal cortex in mice via increasing IFN-γ level. We write the review to facilitate understanding ATP8A2. This review focuses on the structure, function and distribution of ATP8A2 in humans and rodents and the human diseases related to ATP8A2.

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Funding

This work was supported by the starting fund for high-level talent introduction into Guangdong Pharmaceutical University (51355093).

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Authors and Affiliations

  1. Grade 2020, School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China

    Junyuan Zeng

  2. Department of Anatomy, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Higher Education Mega Center, Guangzhou, Guangdong, China

    Junhua Yang

  3. Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Higher Education Mega Center, Guangzhou, Guangdong, China

    Junhua Yang

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  1. Junyuan Zeng
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Correspondence to Junhua Yang.

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Correspondence author; address: Room 510#, Building of Basic Medical Sciences, School of Life Sciences & Biopharmaceutics, Guangdong Pharmaceutical University, No. 280, East Waihuan Street, Higher Education Mega Center, Guangzhou City, Guangdong Province, 510006 P. R. China; e-mail: jhyang2018@gdpu.edu.cn.

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Junyuan Zeng, Junhua Yang Structure, Function and Distribution of ATP8A2 in Human and Mice. Neurochem. J. 17, 443–451 (2023). https://doi.org/10.1134/S1819712423030200

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