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Administration of Curcumin plus Treadmill Exercise Modulate Some Neuronal Enzyme Activities, Redox Markers and BDNF mRNA Expression in Pilocarpine-Induced Epileptic Seizure in Rats

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Abstract

Epilepsy, a chronic neurological illness, takes a heavy emotional toll on patients and their families. It is one of most neglected neurological illnesses in Africa. Studies have shown that epileptic seizures may be managed pharmacologically, behaviorally, and nutritionally. This study aims to investigate the therapeutic potential of combination of curcumin and aerobic exercise in treatment of epileptic seizure in rats. Four groups of Wistar strain albino rats; control, pilocarpine, pilocarpine + curcumin, and pilocarpine + curcumin + exercise was investigated to determine the effects of oral administration of curcumin and treadmill exercise on seizure frequency, activities of monoamine oxidase (MAO) and acetylcholinesterase (AChE), redox markers and Brain-Derived Neurotrophic Factor (BDNF) mRNA expression level in brain cortex and hippocampus of pilocarpine-induced epileptic rats. The results showed a significant reduction in the seizure frequency of rats treated with curcumin and curcumin + exercise groups, when compared with the pilocarpine-induced group. In addition, the significantly elevated MAO and AChE activities were ameliorated, coupled with a significant reduction in reactive oxygen species and thiol contents of the brain tissues of the pilocarpine-induced rats treated with curcumin plus exercise. Furthermore, the downregulated BDNF mRNA expression levels were significantly ameliorated in the induced groups treated with curcumin plus exercise. This study therefore, suggests that treadmill exercise could improve the therapeutic effects of curcumin in the management of epileptic seizure.

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SUPPLEMENTARY INFORMATION

Data associated with this study is available through the corresponding author upon reasonable request.

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ACKNOWLEDGMENTS

Ogunsuyi O.B. is grateful to the International Brain Research Organization (IBRO) for their support towards this work through the 2020 IBRO Return Home Fellowship Award.

Funding

The study was funded by the International Brain Research Organization (IBRO) Return Home Fellowship, 2020.

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Authors and Affiliations

  1. Department of Biomedical Technology, School of Basic Medical Sciences, Federal University of Technology, 704, Akure, P.M.B., Nigeria

    O. B. Ogunsuyi

  2. Drosophila Research Lab, Functional Foods and Nutraceuticals Unit, Federal University of Technology, 704, Akure, P.M.B., Nigeria

    O. B. Ogunsuyi, P. O. Aro & G. Oboh

  3. Biochemistry Department, Federal University of Technology, 704, Akure, P.M.B., Nigeria

    P. O. Aro, H. I. Umar & G. Oboh

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  1. O. B. Ogunsuyi
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Correspondence to O. B. Ogunsuyi.

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Ethical approval. The handling and use of the animals were in accordance with institutional ethical guide and NIH guide for the care and use of laboratory animals.

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Corresponding author; address: Department of Biomedical Technology, School of Basic Medical Sciences, Federal University of Technology, Akure, P.M.B. 704, Nigeria; e-mail: obogunsuyi@futa.edu.ng, opeyemiogunsuyi@gmail.com.

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Ogunsuyi, O.B., Aro, P.O., Umar, H.I. et al. Administration of Curcumin plus Treadmill Exercise Modulate Some Neuronal Enzyme Activities, Redox Markers and BDNF mRNA Expression in Pilocarpine-Induced Epileptic Seizure in Rats. Neurochem. J. 17, 467–476 (2023). https://doi.org/10.1134/S1819712423030145

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