Skip to main content
SpringerLink
Log in

Founders of Neurochemistry at the Sechenov Institute of Evolutionary Physiology and Biochemistry

  • REVIEW ARTICLES
  • Published:
Neurochemical Journal Aims and scope Submit manuscript

Abstract—The formation and development of neurochemistry at the Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences (IEPhB RAS) is closely associated with the name of its founder, the outstanding Russian physiologist, Academician Leon Abgarovich Orbeli. Orbeli not only became the founder and ideological inspirer of a new field of physiological science—evolutionary physiology, but also assigned the greatest importance to the study of the chemical and cellular mechanisms of the functioning of the central nervous system, considering them the “core” of the implementation of many physiological functions in his works. His work was worthily continued by his disciples and followers, Academician Evgeny Mikhailovich Kreps and Corresponding Member Andrei Lvovich Polenov, one of the founders of modern neurochemistry and neuroendocrinology in Russia. At the heart of their scientific approach, in full agreement with the traditions laid down by L.A. Orbeli, is not a static analysis of biochemical and regulatory processes in neurons and glial cells, but the study of chemical interactions between nerve cells, between regions of the brain, and between the brain and visceral organs, which are constantly changing in ontogeny, phylogeny, when under the influence of various external and endogenous factors, and in pathological conditions. Only this approach can explain the subtle mechanisms of the functioning of individual neurons, the brain and the entire body as a whole, as well as identify the molecular causes of diseases of the nervous, endocrine and other systems. The creative heritage of L.A. Orbeli, E.M. Kreps and A.L. Polenov is the numerous scientific schools of neurochemists and neuroendocrinologists at IEPhB RAS and in other scientific institutions of Russia, which successfully develop the creative heritage of their teachers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. Orbeli, L.A., Izbrannye trudy (v 5-ti tomakh). T. 1. Voprosy evolyutsionnoi fiziologii (Selected Writings (in 5 volumes). V.1. Questions of evolutionary physiology), Koshtoyants, S., Ed., Moscow–Leningrad: Akad. nauk SSR, 1961.

  2. Orbeli L.A., Vospominaniya (Memoirs), Kreps, E.M, Eds., Moscow: Nauka, 1966.

  3. Leibson, L.G., Akademik Orbeli. Neopublikovannye glavy biografii (Academician Orbeli. Unpublished Chapters of Biography), Leningrad: Nauka, 1990.

  4. Orbeli, L.A., Izbrannye trudy (v 5-ti tomakh). T. 2. Adaptatsionno-troficheskaya funktsiya nervnoi sistemy (Selected Writings (in 5 volumes). V.2. Adaptation-Trophic Function of Nervous System), Kreps, E.M, Ed., Moscow–Leningrad: Akad. nauk SSR, 1962 .

  5. Orbeli, L.A., Izbrannye trudy (v 5-ti tomakh). T. 3. Voprosy vysshei nervnoi deyatel’nosti i ee razvitiya (Selected Writings (in 5 volumes). V. 3. Problems of Higher Nervous Activity and its Development), Kreps, E.M, Ed., Moscow–Leningrad: Akad. nauk SSR, 1964.

  6. Orbeli, L.A., Lektsii po fiziologii nervnoi sistemy. 3-e izd., ispr. i dop. (Lectures on Physiology of Nervous System. Third Edition), Moscow–Leningrad: Medgiz, Leningradskoe otdelenie, 1938.

  7. Orbeli, L.A., Voprosy vysshei nervnoi deyatel’nosti. Lektsii i doklady, 1922-1949 gg (Problems of Higher Nervous Activity. Lectures and Reports. 1922–1949), Moscow–Leningrad: Medgiz, Leningradskoe otdelenie, 1949.

  8. Orbeli, L.A., Fiziol. Zh. SSSR Im. I.M. Sechenova, 1949, vol. 35, p. 594.

    CAS  Google Scholar 

  9. Kreps, E.M., Na “Vityaze” k ostrovam Tikhogo okeana (On “Vityaz” to Isles of Pacific Ocean), Moscow: Geografgiz, 1959.

  10. Kreps, E.M., Poslednyaya ekspeditsiya “Vityazya” (The Last Expedition of “Vityaz”), Moscow: Mysl’, 1983.

  11. Kreps, E.M., O prozhitom i perezhitom. Seriya “Uchenye SSSR. Ocherki, vospominaniya, materialy” (On Lived and Experienced. Series “Scientists of USSR. Sketches, Memoirs, Materials), Moscow: Nauka, 1989.

  12. Kreps, E.M., Ya prozhil interesnuyu zhizn': izbrannye trudy (I Lived Interesting Life: Selected Works), Saint-Petersburg: Nauka, Sankt-Peterburgskaya izdatel’skaya firma, 2007.

  13. Natochin, Yu.V. and Rozengart, E.V., Vestnik RAN, 1999, vol. 69, pp. 337–343.

    Google Scholar 

  14. Natochin, Yu.V., Ros. fiziol. zhurn. im. I.M. Sechenova, 2007, vol. 93, pp. 719–734.

    Google Scholar 

  15. Natochin, Yu.V., Istoriko-biologicheskie issledovaniya, 2021, vol. 13, pp. 72–88.

  16. Ostrovskii, A.N., Priroda, 2009, no. 12, pp. 59–68.

  17. Kreps, E.M., Verzhbinskaia, N.A., Chenykaeva, E.Iu., Chirkovskaia, E.V., and Gavurina, Ts.K., Fiziol. Zh. SSSR Im. I.M. Sechenova, 1956, vol. 42, pp. 456–463.

    CAS  Google Scholar 

  18. Kreps, E.M., Tr. Inst. Fiziol. Im. I.P. Pavlova, 1959, vol. 8, pp. 543–548.

    CAS  Google Scholar 

  19. Kreps, E.M., Prog. Nucl. Energy. Biol. Sci., 1958, vol. 2, pp. 446–456.

    CAS  Google Scholar 

  20. Kreps, E.M., Manukyan, K.G., Smirnov, A.A., and Chirkovskaya, E.V., Biokhimiia, 1963, vol. 28, pp. 978–986.

    CAS  Google Scholar 

  21. Kreps, E.M., Lipidy kletochnykh membran (Lipids of Cell Membranes), Leningrad: Nauka, Leningradskoe otdelenie, 1981.

  22. Kreps, E.M., Ukr. Biokhim. Zh., 1965, vol. 37, pp. 734–741.

    CAS  Google Scholar 

  23. Kreps, E.M., Neurosci. Behav. Physiol., 1978, vol. 9, pp. 75–82.

    Article  CAS  Google Scholar 

  24. Kreps, E.M., Manukyan, K.G., Patrikeeva, M.V., Smirnov, A.A., Chenykaeva, N.Y., and Chirkovskaya, E.V., Fed. Proc. Transl., vol. 25, no. Suppl. 1966, pp. 277–282.

  25. Kreps, E.M., Zh. Evol. Biokhim. Fiziol., 1976, vol. 12, pp. 493–502.

    CAS  Google Scholar 

  26. Kreps, E.M., Avrova, N.F., Zabelinskii, S.A., Kruglova, E.E., and Levitina, M.V., Zh. Evol. Biokhim. Fiziol., 1977, vol. 13, pp. 556–559.

    CAS  Google Scholar 

  27. Kreps, E.M., Chirkovskaia, E.V., Pomazanskaia, L.F., Avrova, N.F., and Levitina, M.V., Zh. Evol. Biokhim. Fiziol., 1979, vol. 15, pp. 227–238.

    CAS  Google Scholar 

  28. Kreps, E.M., Chebotareva, M.A., and Akulin, V.N., Comp. Biochem. Physiol., 1969, vol. 31, pp. 419–430.

    Article  CAS  Google Scholar 

  29. Kreps, E.M., Avrova, N.F., Krasil’nikova, V.I., Levitina, M.V., and Obukhova, E.L., Zh. Evol. Biokhim. Fiziol., 1973, vol. 9, pp. 30–38.

    CAS  Google Scholar 

  30. Kreps, E.M., Avrova, N.F., Chebotareva, M.A., Chirkovskaya, E.V., Krasilnikova, V.I., Kruglova, E.E., Levitina, M.V., Obukhova, E.L., Pomazanskaya, L.F., Pravdina, N.I., and Zabelinskii, S.A., Comp. Biochem. Physiol., 1975, vol. 52, pp. 283–292.

    CAS  Google Scholar 

  31. Kreps, E.M., Avrova, N.F., Chebotareva, M.A., Chirkovskaya, E.V., Levitina, M.V., Pomazanskaya, L.F., and Pravdina, N.I., Comp. Biochem. Physiol., 1975, vol. 52, pp. 293–299.

    CAS  Google Scholar 

  32. Kreps, E.M., Avrova, N.F., Krasil’nikova, V.I., Kruglova, E.E., Levitina, M.V., Obukhova, E.L., Pomazanskaya, L.F., Pravdina, N.I., Chebotareva, M.A., and Chirkovskaya, E.V., Zh. Evol. Biokhim. Fiziol., 1975, vol. 11, pp. 233—241.

    CAS  Google Scholar 

  33. Kreps, E.M., Tiurin, V.A., Chelomin, V.P., Gorbunov, N.V., and Nalivaeva, N.N., Zh. Evol. Biokhim. Fiziol., 1987, vol. 23, pp. 461–467.

    CAS  Google Scholar 

  34. Zakharova, I.O., Sokolova, T.V., Akhmetshina, A.O., and Avrova, N.F., Bull. Exp. Biol. Med., 2015, vol. 159, pp. 610–613.

    Article  CAS  Google Scholar 

  35. Sukhov, I.B., Lebedeva, M.F., Zakharova, I.O., Derkach, K.V., Bayunova, L.V., Zorina, I.I., Avrova, N.F., and Shpakov, A.O., Bull. Exp. Biol. Med., 2020, vol. 168, pp. 317–320.

    Article  CAS  Google Scholar 

  36. Zakharova, I.O., Sokolova, T.V., Vlasova, Y.A., Bayunova, L.V., Rychkova, M.P., and Avrova, N.F., Int. J. Mol. Sci., 2017, vol. 18, p. 216.

    Article  Google Scholar 

  37. Zakharova, I.O., Bayunova, L.V., Zorina, I.I., Sokolova, T.V., Shpakov, A.O., and Avrova, N.F., Int. J. Mol. Sci., 2021, vol. 22, p. 11768.

    Article  CAS  Google Scholar 

  38. Polenov, A.L., Gipotalamicheskaya neirosekretsiya (Hypothalamic Neurosecretion), Leningrad: Nauka, Leningradskoe otdelenie, 1968.

  39. Polenov, A.L., Garlov, P.E., Koryakina, E.D., and Faleeva, T.I., Cell Tissue Res., 1976, vol. 170, pp. 113–128.

    Article  CAS  Google Scholar 

  40. Polenov, A.L., Belenky, M.A., Garlov, P.E., and Konstantinova, M.S., Cell Tissue Res., 1976, vol. 170, pp. 129–144.

    Article  CAS  Google Scholar 

  41. Polenov, A.L., Belenky, M.A., Kornienko, G.G., and Konstantinova, M.S., Cell Tissue Res., 1984, vol. 237, pp. 139–147.

    Article  CAS  Google Scholar 

  42. Polenov, A.L., Kornienko, G.G., and Belenky, M.A., Z. Mikrosk. Anat. Forsc., 1986, vol. 100, pp. 990–1006.

    CAS  Google Scholar 

  43. Belenky, M.A., Konstantinova, M.S., and Polenov, A.L., Cell Tissue Res., 1979, vol. 204, pp. 319–331.

    Article  CAS  Google Scholar 

  44. Chetverukhin, V.K., Selivanova, G.V., Onischenko, L.S., Vlasova, T.D., and Polenov, A.L., Histochemistry, 1988, vol. 88, pp. 629–636.

    Article  CAS  Google Scholar 

  45. Chetverukhin, V.K. and Polenov, A.L., Cell Tissue Res., 1993, vol. 271, pp. 341–350.

    Article  CAS  Google Scholar 

  46. Polenov, A.L. and Yurisova, M.N., Z. Mikrosk. Anat. Forsc., 1975, vol. 89, pp. 991–1014.

  47. Arshavskaya, T.V., Polenov, A.L., and Tkachev, A.V., Z. Mikrosk. Anat. Forsc., 1984, vol. 98, pp. 580–596.

    CAS  Google Scholar 

  48. Polenov, A.L., Efimova, N.A., Konstantinova, M.S., Senchik, Y.I., and Yakovleva, I.V., Cell Tissue Res., 1983, vol. 232, pp. 651–667.

    Article  CAS  Google Scholar 

  49. Arshavskaya, T.V. and Polenov, A.L., Z. Mikrosk. Anat. Forsc., 1989, vol. 103, pp. 648–663.

    CAS  Google Scholar 

  50. Arshavskaya, T.V., Polenov, A.L., and Tkachev, A.V., Z. Mikrosk. Anat. Forsc., 1989, vol. 103, pp. 627–647.

    CAS  Google Scholar 

  51. Polenov, A.L., Belenky, M.A., and Bogdanovic-Stosic, N., Cell Tissue Res., 1981, vol. 218, pp. 607–622.

    Article  CAS  Google Scholar 

  52. Polenov, A.L., Kuzik, V.V., and Danilova, O.A., Gen. Comp. Endocrinol., 1997, vol. 105, pp. 314–322.

    Article  CAS  Google Scholar 

  53. Polenov, A.L., Ugrumov, M.V., and Belenky, M.A., Cell Tissue Res., 1975, vol. 160, pp. 113–123.

    Article  CAS  Google Scholar 

  54. Farmer, S.W., Hayashida, T., Papkoff, H., and Polenov, A.L., Endocrinology, 1981, vol. 108, pp. 377–381.

    Article  CAS  Google Scholar 

  55. McMaster, D., Belenky, M.A., Polenov, A.L., and Lederis, K., Gen. Comp. Endocrinol., 1992, vol. 87, pp. 275–285.

    Article  CAS  Google Scholar 

  56. Yasuda, A., Yamaguchi, K., Noso, T., Papkoff, H., Polenov, A.L., Nicoll, C.S., and Kawauchi, H., Biochim. Biophys. Acta, 1992, vol. 1120, pp. 297–304.

    Article  CAS  Google Scholar 

  57. Noso, T., Nicoll, C.S., Polenov, A.L., and Kawauchi, H., Gen. Comp. Endocrinol., 1993, vol. 91, pp. 90–95.

    Article  CAS  Google Scholar 

  58. Belenky, M.A., Kuzik, V.V., Chernigovskaya, E.V., and Polenov, A.L., Gen. Comp. Endocrinol., 1985, vol. 60, pp. 20–26.

    Article  CAS  Google Scholar 

  59. Gonzalez, G.C., Belenky, M.A., Polenov, A.L., and Lederis, K., J. Neurocytol., 1992, vol. 21, pp. 885–896.

    Article  CAS  Google Scholar 

  60. Polenov, A.L. and Kulakovskii, E.E., Neiroendokrinologiya (v trekh tomakh). Kniga 1, chast' 1 (Neuroendocrinology (in 3 volumes). Vol. 1. Part 1), Polenov, A.L., Ed., Saint-Petersburg: Izd. VIR, 1993.

  61. Polenov, A.L., Kulakovskii, E.E., and Prutskova, N.P., Neiroendokrinologiya (v trekh tomakh). Kniga 1, chast' 2 (Neuroendocrinology (in 3 volumes). Vol. 1. Part 2), Polenov, A.L, Ed., Saint-Petersburg: Izd. VIR, 1993.

  62. Evolyutsionnaya fiziologiya. Chast’ 2 (Evolutionary Physiology. Part 2), Kreps, E.M, Ed., Leningrad: Nauka, 1983.

  63. Romanova, I.V., Mikhrina, A.L., and Shpakov, A.O., Dokl. Biol. Sci., 2017, vol. 472, pp. 11–14.

    Article  CAS  Google Scholar 

  64. Romanova, I.V., Derkach, K.V., Mikhrina, A.L., Sukhov, I.B., Mikhailova, E.V., and Shpakov, A.O., Neurochem. Res., 2018, vol. 43, pp. 821–837.

    Article  CAS  Google Scholar 

  65. Derkach, K., Zakharova, I., Zorina, I., Bakhtyukov, A., Romanova, I., Bayunova, L., and Shpakov, A., PLoS One, 2019, vol. 14.

  66. Pavlov, I.P., Privetstvennoe poslanie Direktoru Psikhologicheskogo Instituta im. L.G. Shchukinoi prof. G.I. Chelpanovu v chest' otkrytiya 23 marta 1914 g (Wellcome Address to Prof. G.I. Chepanov, Director of Shchukina Psychological Institute, in Honor of Opening on March 23, 1914).

Download references

Funding

The work was performed within the state task of the IEPhB RAS No. 075-0152-22-00.

Author information

Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    A. O. Shpakov

Authors
  1. A. O. Shpakov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. O. Shpakov.

Ethics declarations

Conflict of interests. The author declares that he has no conflict of interest.

Additional information

Corresponding author; address: pr. Toreza 44, St. Petersburg, 194223 Russia; e-mail: alex_shpakov@list.ru.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shpakov, A.O. Founders of Neurochemistry at the Sechenov Institute of Evolutionary Physiology and Biochemistry. Neurochem. J. 16, 369–378 (2022). https://doi.org/10.1134/S1819712422040201

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1819712422040201

Keywords:

Search

Navigation