Skip to main content
SpringerLink
Log in

The Role of Impulsive and Aggressive Traits, Albumin and Thyroid Functions in Recent Suicide Attempters: An Investigation with a Transdiagnostic Approach

  • CLINICAL NEUROCHEMISTRY
  • Published:
Neurochemical Journal Aims and scope Submit manuscript

Abstract

Suicide is a complex behavior involving multiple psychological and biological factors. However, multidimensional and transdiagnostic approaches, including behavioral and biological correlates to suicidal behavior, are currently lacking. In this study we examined the role of impulsive and aggressive traits as well as thyroid function and serum albumin levels in the emergence of suicidal behavior in patients with different psychiatric diagnoses. Sixty patients (30 males and 30 females) with various psychiatric diagnoses who attempted suicide recently and sixty age- and gender-matched non-suicidal healthy subjects were included in the study. Albumin and thyroid hormone levels on admission were recorded and Barratt Impulsiveness Scale-11 (BIS-11), Buss-Perry Aggression Questionnaire (BPAQ) were administered to all subjects. Patients who underwent a suicide attempt had higher BIS-11 and BPAQ scores and serum fT4 levels, while serum albumin and TSH were significantly higher in the non-suicidal group. According to univariate and multivariate regression analyses, high BIS-11, BPAQ scores and low TSH levels were significant independent predictors of recent suicidal behavior. Our findings indicate that there is a robust relationship between suicidal behavior, thyroid dysfunction and low serum albumin. High impulsive and aggressive traits may be involved this relationship.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Steelesmith, D.L., Fontanella, C.A., Campo, J.V., Bridge, J.A, Warren, K. L., and Root, E.D., Jama Netw. Open, 2019, vol. 2, no. 9, pp. e1910936.

    Article  Google Scholar 

  2. Van Heeringen, K. and Mann, J.J., Lancet Psychiatry, 2014, vol. 1, no. 1, pp. 63–72.

    Article  Google Scholar 

  3. Balcioglu, Y.H. and Kose, S., Psychiatry Clin. Psychopharmacol., 2018, vol. 28, no. 3, pp. 314–328.

    Article  CAS  Google Scholar 

  4. Gokcay, H. and Balcioglu, Y., Psychiatry Behav. Sci., 2020, vol. 10, no. 4, pp. 206–215.

    Google Scholar 

  5. Mann, J.J. and Currier, D., Arch. Suicide Res., 2007, vol. 11, no. 1, pp. 3–16.

    Article  Google Scholar 

  6. Bauer, M., Goetz, T., Glenn, T., and Whybrow, P. C., J. Neuroendocrinol., 2008, vol. 20, no. 10, pp. 1101–1114.

    Article  CAS  Google Scholar 

  7. Eng, L. and Lam, L., Neoreviews, 2020, vol. 21, no. 1, pp. e30–e36.

    Article  Google Scholar 

  8. Pompili, M., Gibiino, S., Innamorati, M., Serafini, G., Del Casale, A., De Risio, L., Palermo, M., Montebovi, F., Campi, S., De Luca, V., Sher, L., Tatarelli, R., Biondi, M., Duval, F., Serretti, A., and Girardi, P., Psychiatry Res., 2012, vol. 200, no. 2–3, pp. 389–394.

    Article  CAS  Google Scholar 

  9. Jose, J., Nandeesha, H., Kattimani, S., Meiyappan, K., Sarkar, S., and Sivasankar, D., Clin. Chim. Acta, 2015, vol. 444, pp. 78–80.

    Article  CAS  Google Scholar 

  10. Duval, F., Mokrani, M.C., Lopera, F. G., Diep, T.S., Rabia, H., and Fattah, S., Psychoneuroendocrinology, 2010, vol. 35, no. 7, pp. 1045–1054.

    Article  CAS  Google Scholar 

  11. De Luca, R., Davis, P.J., Lin, H.Y., Gionfra, F., Percario, Z.A., Affabris, E., Pedersen, J.Z., Marchese, C., Trivedi, P., Anastasiadou, E., Negro, R., and Incerpi, S., Front. Cell Dev. Biol., 2021, vol. 8, p. 614030.

    Article  Google Scholar 

  12. Bergmans, R. S., Kelly, K.M., and Mezuk, B., . Affect. Disord., 2019, vol. 245, pp. 1052–1060.

    Article  Google Scholar 

  13. Soderstrom, H. and Forsman, A., J. Neural Transm., 2004, vol. 111, no. 6, pp. 739–744.

    Article  CAS  Google Scholar 

  14. Evrensel, A., Ünsalver, B.Ö., and Özşahin, A., Noropsikiyatri Ars., 2016, vol. 53, no. 2, pp. 120–125.

    Google Scholar 

  15. Ritchie, R.F., Palomaki, G.E., Neveux, L.M., Navolotskaia, O., Ledue, T.B., and Craig, W.Y., J. Clin. Lab. Anal., 2002, vol. 16, no. 5, pp. 237–245.

    Article  CAS  Google Scholar 

  16. Powanda, M.C. and Moyer, E.D., Inflammopharmacology, 2021, vol. 29, no. 3, pp. 897–901.

    Article  CAS  Google Scholar 

  17. Mahendhar, R., Shahbaz, A., Riaz, M., Aninyei, M., Reich, D. M., and Sachmechi, I., Cureus, 2018, vol. 10, no. 7, pp. e2903.

    Google Scholar 

  18. Tabata, F., Wada, Y., Kawakami, S., and Miyaji, K., Antioxidants (Basel, Switzerland), vol. 10, no. 4, p. 503.

  19. Liu, T., Zhong, S., Liao, X., Chen, J., He, T., Lai, S., and Jia, Y., PLoS One, 2015, vol. 10, no. 10, p. e0138904.

    Article  Google Scholar 

  20. Vargas, H.O., Nunes, S.O., Pizzo de Castro, M., Bortolasci, C.C., Sabbatini Barbosa, D., Kaminami Morimoto, H., Venugopal, K., Dodd, S., Maes, M., and Berk, M., J. Affect. Disord., 2013, vol. 150, no. 3, pp. 923–930.

    Article  Google Scholar 

  21. Ambrus, L. and Westling, S., Nord. J. Psychiatry, 2019, vol. 73, no. 4–5, pp. 229–232.

    Article  Google Scholar 

  22. Kim, M.K., Kwon, H.S., Baek, K. H., Lee, J.H., Park, W.C., Sohn, H. S., Lee, K.W., and Song, K.H., Diabetes Care, 2010, vol. 33, no. 12, pp. 2546–2548.

    Article  CAS  Google Scholar 

  23. First, M.B., Structured clinical interview for the DSM (SCID), The Encyclopedia of Clinical Psychology, John Wiley & Sons, Ltd, 2015, pp. 1–6.

  24. Elbir, M., Alp Topbas, O., Bayad, S., Kocabas, T., Topak, Z., Cetin, S., Sahabettin, C., Ozdel, O., Atesci, F.C., and Aydemir, O., Turk Psikiyatr. Derg., 2019, vol. 30, no. 1, pp. 51–56.

    Google Scholar 

  25. Güleç, H., Tamam, Lut., Güleç, M.Y., Turhan, M., Karakuş, Gonca., Zengin, M., and Stanford, M., Klin. Psikofarmakol. Bul., 2008, vol. 18, no. 4, pp. 251–258.

    Google Scholar 

  26. Patton, J.H., Stanford, M.S., and Barratt, E.S., J. Clin. Psychol., 1995, vol. 51, no. 6, pp. 768–774.

    Article  CAS  Google Scholar 

  27. Demirtas-Madran, H., Turkish J. Psychiatry, 2012, vol. 24, no. 2, p. 124.

    Google Scholar 

  28. Buss, A.H. and Perry, M., J. Pers. Soc. Psychol., 1992, vol. 63, no. 3, pp. 452–459.

    Article  CAS  Google Scholar 

  29. Duval, F., Mokrani, M.C., Erb, A., Gonzalez Opera, F., Calleja, C., and Paris, V., Psychoneuroendocrinology, 2017, vol. 85, pp. 100–109.

    Article  CAS  Google Scholar 

  30. Peng, R., Dai, W., and Li, Y., Psychiatry Res., 2018, vol. 266, pp. 111–115.

    Article  CAS  Google Scholar 

  31. Joffe, R.T. and Levitt, A.J., Can. J. Psychiatry, 2008, vol. 53, no. 12, pp. 833–838.

    Article  Google Scholar 

  32. Dumais, A., Lesage, A.D., Alda, M., Rouleau, G., Dumont, M., Chawky, N., Roy, M., Mann, J.J., Benkelfat, C., and Turecki, G., Am. J. Psychiatry, 2005, vol. 162, no. 11, pp. 2116–2124.

    Article  CAS  Google Scholar 

  33. Doihara, C., Kawanishi, C., Yamada, T., Sato, R., Hasegawa, H., Furuno, T., Nakagawa, M., and Hirayasu, Y., Psychiatry Clin. Neurosci., 2008, vol. 62, no. 3, pp. 352–354.

    Article  Google Scholar 

  34. Gvion, Y., and Apter, A., Arch. Suicide Res., 2011, vol. 15, no. 2, pp. 93–112.

    Article  Google Scholar 

  35. Sinai, C., Hirvikoski, T., Vansvik, E.D., Nordström, A.L., Linder, J., Nordström, P., and Jokinen, J., Psychoneuroendocrinology, 2009, vol. 34, no. 10, pp. 1526–1532.

    Article  CAS  Google Scholar 

  36. Cleare, A.J., McGregor, A., Chambers, S.M., Dawling, S., and O’Keane, V., Neuroendocrinology, 1996, vol. 64, no. 1, pp. 65–69.

    Article  CAS  Google Scholar 

  37. Sullo, A., Brizzi, G., and Maffulli, N., Can. J. Physiol. Pharmacol., 2003, vol. 81, no. 7, pp. 747–751.

    Article  CAS  Google Scholar 

  38. Fujiwara, S.I. and Amisaki, T., Biochim. Biophys. Acta - Gen. Subj., 2013, vol. 1830, no. 12, pp. 5427–5434.

    Article  CAS  Google Scholar 

Download references

Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

Author information

Authors and Affiliations

  1. University of Health Sciences, Bagcilar Training and Research Hospital, Department of Psychiatry, Istanbul, Turkey

    Hasan Gokcay & Mustafa Solmaz

  2. Bakirkoy Prof. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Forensic Psychiatry Unit, Istanbul, Turkey

    Yasin Hasan Balcioglu

Authors
  1. Hasan Gokcay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasin Hasan Balcioglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mustafa Solmaz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yasin Hasan Balcioglu.

Ethics declarations

Conflict of interest. The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical approval. All procedures in the study involving human participants conformed to the 1964 Declaration of Helsinki or ethical standards. The study was approved by the Local Ethics Committee (IRB: 07/02/2020— 2020.02.1.13.018.r2.030).

Informed consent. Written informed consent was obtained from all participants and, if any, their legal representatives/guardians following a thorough explanation of the study procedure.

Additional information

Corresponding author; address: Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Department of Psychiatry, 34147, Istanbul, Turkey. e-mail: yhasanbalcioglu@gmail.com.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hasan Gokcay, Balcioglu, Y.H. & Solmaz, M. The Role of Impulsive and Aggressive Traits, Albumin and Thyroid Functions in Recent Suicide Attempters: An Investigation with a Transdiagnostic Approach. Neurochem. J. 16, 491–497 (2022). https://doi.org/10.1134/S1819712422040079

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1819712422040079

Keywords:

Search

Navigation