Abstract
This study aimed to investigate the effects of Xinnao shutong capsules (XSC) on the recovery of cerebral circulation and neurological and motor functions following cerebral infarction. Eighty patients admitted to the neurology department of our hospital were enrolled and randomly divided into control and intervention groups (n = 40 for each group). Patients in the control group received comprehensive treatment, including Western medicine and motor rehabilitation, while the intervention group was additionally treated with XSC. After 4 weeks, cerebral circulation, National Institutes of Health Stroke Scale (NIHSS) scores, and Functional Independence Measure (FIM) scores were measured to evaluate neurological and motor function. After 4 weeks of treatment, the effective rate of the intervention and control groups was 82.5 and 67.5%, respectively, showing significant differences between the two groups (P < 0.05); Vmin and Qmin were increased and R was decreased in the cerebral circulation of the intervention group, and were significantly different from those of the control group (P < 0.05); the NIHSS score decreased and the FIM score increased in the two groups. Hypersensitive C-reactive protein (hs-CRP), brain-derived neurotrophic factor (BDNF), and angiopoietin-2 (Ang-2) levels were improved in both groups. The intervention group showed lower NIHSS scores and higher FIM scores than the control group (P < 0.05); hs-CRP was lower and BDNF levels were higher in the intervention group than in the control group (P < 0.05). Ang-2 levels did not differ significantly between the two groups (P > 0.05); malondialdehyde and matrix metalloproteinase-9 levels were lower and superoxide dismutase levels were higher in the intervention group than in the control group (P < 0.05). XSC significantly improved patients' cerebral circulation and motor and neurological function, effectively reduced oxidative stress, and improved clinical efficacy.
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Ethical approval. This study was approved by the Ethics Committee of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine. All study participants provided written informed consent before participating in the study.
Informed consent. Informed consent was obtained from all participants included in the study.
Data availability statement. The data used to support the findings of this study are available from the corresponding author upon request.
Author contributions: Liqun Zhao, Kaihua Rao, and Xiumei Xu designed the research plan. Liqun Zhao, Kaihua Rao, Xuanrong Zhu, and Xiumei Xu performed the experiments. X. X. and Y. Y. wrote the manuscript.
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Corresponding author; address: Department of Encephalopathy, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, No. 445, Bayi Avenue, Nanchang, Jiangxi 330006 China; phone: +86–0791-86362617; e-mail: xuxiumei76@aliyun.com.
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Zhao, L.Q., Rao, K.H., Zhu, X.R. et al. The Effect of Xinnao Shutong Capsules on Cerebral Circulation and Neurological and Motor Functions during Cerebral Infarction Recovery. Neurochem. J. 16, 349–355 (2022). https://doi.org/10.1134/S1819712422030151
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DOI: https://doi.org/10.1134/S1819712422030151