Skip to main content
Log in

The Effect of Noopept on the Content of Monoamines and Their Metabolites and Neurotransmitter Amino Acids in the Brain Structures of BALB/c and C57BL/6 Mice: A Comparative Study

  • EXPERIMENTAL ARTICLES
  • Published:
Neurochemical Journal Aims and scope Submit manuscript

Abstract—The aim of this study was to compare neurochemical changes induced by the dipeptide analogue of piracetam, the ethyl ester of N-phenylacetyl-L-prolylglycine (noopept), in the brain structures of BALB/c and C57BL/6 mice with different genetically determined responses to emotional stress. It was found using the HPLC technique that noopept at doses of 0.5 and 2.5 mg/kg after acute administration reduced the content of dopamine (DA) and its metabolite homovanillic acid (HVA) in the frontal cortex of both strains of mice. In “highly anxious” BALB/c mice, noopept increased the intracellular DA turnover (DOPAC/DA) and the total DA turnover (HVA/DA) in the frontal cortex, increased the level of noradrenaline and the metabolic rate of DA and serotonin in the hypothalamus, and increased the total DA turnover in the striatum. Noopept had no effect on the content of neurotransmitter amino acids in the brain structures of mice of both strains.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. Ostrovskaya, R.U., Gudasheva, T.A., Voronina, T.A., and Seredenin, S.B., Eksperimental’naya i klinicheskaya farmakologiya, 2002, vol. 65, no. 5, pp. 66–72.

  2. Bochkarev, V.K., Teleshova, E.S., Syunyakov, S.A., Davydova, D.V., and Neznamov, G.G., Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova, 2008, vol. 108, no. 11, pp. 47–54.

    CAS  Google Scholar 

  3. Neznamov, G.G. and Teleshova, E.S., Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova, 2008, vol. 108, no. 3, pp. 33–42.

    CAS  Google Scholar 

  4. Ostrovskaya, R.U. and Gudasheva, T.A., Eksperimental’naya i Klinicheskaya Farmakologiya, 2021, vol. 84, no. 2, pp. 41–52.

  5. Ostrovskaya, R.U., Seredenin, S.B., Voronina, T.A., Molodavkin, G.M., and Gudasheva, T.A., in Animal Models in Biological Psychiatry, Kalueff, A.V, Ed., USA: Nova Science Publ., 2006, pp. 165-182 .

    Google Scholar 

  6. Bel’nik, A.P., Ostrovskaya, R.U., and Poletaeva, I.I., Zhurnal Vysshei nervnoi deyatel’nosti im. I. P. Pavlova, 2007, vol. 57, no. 5, pp. 613–617.

    Google Scholar 

  7. Bel’nik, A.P., Ostrovskaya, R.U., and Poletaeva, I.I., Zhurnal Vysshei Nervnoi Deyatel’nosti im. I.P. Pavlova, 2007, vol. 57, no. 6, pp. 717–724.

    Google Scholar 

  8. Kovalev, G.I., Kondrakhin, E.A., Salimov, R.M., and Neznamov, G.G., Eksperimental’naya i Klinicheskaya Farmakologiya, 2014, vol. 77, no. 12, pp. 49–55.

  9. Vasil’eva, E.V., Kondrakhin, E.A., Abdullina, A.A., Salimov, R.M., and Kovalev, G.I., Neurochem. J., 2020, vol. 14, no. 3, pp. 268–278.

    Article  Google Scholar 

  10. Nadorova, A.V., Kolik, L.G., Klodt, P.M., Narkevich, V.B., Naplekova, P.L., Kozlovskaya, M.M., Kudrin, V.S., and Seredenin, S.B., Neurochem. J., 2014, vol. 8, no. 2, pp. 115–120.

    Article  CAS  Google Scholar 

  11. Kolik, L.G., Nadorova, A.V., Kon’kov, V.G., Narkevich, V.B., and Kudrin, V.S., Neurochem. J., 2021, vol. 15, no. 2, pp. 196–202.

    Article  CAS  Google Scholar 

  12. Narkevich, V.B., Kudrin, V.S., Klodt, P.M., Pokrovskii, A.A., Kozlovskaya, M.M., Maiskii, A.I., and Raevskii, K.S., Eksperimental’naya i Klinicheskaya Farmakologiya, 2008, vol. 71, no. 5, pp. 28–31.

  13. Messiha, F., Neurotoxicol., 1991, vol. 12, no. 1, pp. 47–54.

    CAS  Google Scholar 

  14. Messiha, F., Toxicol. Letters, 1991, vol. 58, pp. 77–84.

    Article  CAS  Google Scholar 

  15. Anderzhanova, E.A., Bachli, H., Buneeva, O.A., Narkevich, V.B., Medvedev, A.E., Thoeringer, C.K., Wotjak, C.T., and Kudrin, V.S., Eur. J. Pharmacol., 2013, vol. 708, pp. 95–104.

    Article  CAS  Google Scholar 

  16. Siesser, W.B., Zhang, X., Jacobsen, J.P.R., Sotnikova, T.D., Gainetdinov, R.R., and Caron, M.G., Neurosci. Let., 2010, vol. 481, no. 1, pp. 6–11.

    Article  CAS  Google Scholar 

  17. Bach, H., Arango, V., Huang, Y.Y., Leong, S., Mann, J.J., and Underwood, M.D., J. Neurochem., 2011, vol. 118, no. 6, pp. 1067–1074.

    Article  CAS  Google Scholar 

  18. Kovalev, G.I., Kondrakhin, E.A., Salimov, R.M., and Neznamov, G.G., Eksperimental’naya i Klinicheskaya Farmakologiya, 2013, vol. 76, no. 9, pp. 3–10.

    CAS  Google Scholar 

  19. Povarov, I.S., Kondratenko, R.V., Derevyagin, V.I., Ostrovskaya, R.U., and Skrebitskii, V.G., Byulleten’ Eksperimental’noi Biologii i Meditsiny, 2014, vol. 158, no. 9, pp. 336–338.

    Google Scholar 

  20. Ostrovskaya, R.U., Gudasheva, T.A., Tsaplina, A.P., Vahitova J.V., Salimgareeva M.H., Jamidanov R.S., and Seredenin S.B., Byulleten’ Eksperimental’noi Biologii i Meditsiny, 2008, vol. 146, no. 9, pp. 310–313.

    Google Scholar 

  21. Vorobyov, V., Kaptsov, V., Kovalev, G., and Sengpiel, F., Brain Res. Bul., 2011, vol. T. 85, nos. 3–4, pp. 123–132.

  22. Us, K.S., Klodt, P.M., Kudrin, V.S., Sapronova, A.Ya., Ostrovskaya, R.U., Ugryumov, M.V., Rayevsky, K.S., Neurochem. J., 2007, vol. 1, pp. 138–142.

    Article  Google Scholar 

  23. Kolesnikov, A.V., Shchul’kin, A.V., Barenina, O.I., Yakusheva, E.N., Kudrin, V.S., Ostrovskaya, R.U., Uzbekov, M.G., and Shishkin, M.M., Neurochem. J., 2019, vol. 13, pp. 62–67.

    Article  Google Scholar 

Download references

Funding

The work was supported by the Ministry of Science and Higher Education of the Russian Federation.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to V. G. Kon’kov.

Ethics declarations

Conflict of interest. The authors declare that they have no conflicts of interest.

Ethical approval. The study was performed in accordance with the Directive of the Council of the European Community 2010/63/EEC, the decision of the Council of the Eurasian Economic Commission from November 3, 2016, no. 81 “On approval of the Rules of good laboratory practice in the Eurasian Economic Union in the field of circulation of medicines” and the order of the Ministry of Health of Russia no. 199 dated April 1, 2016 “On approval of the rules of good laboratory practice”. The animals were kept in accordance with SP 2.2.1.3218-14 “Sanitary and epidemiological requirements for the arrangement, equipment and maintenance of experimental biological clinics (vivariums)" dated August 29, 2014, No. 51.

Additional information

V. G. Kon’kov is a corresponding author: 125315 Russia, Moscow, Baltiiskaya ul., 8, e-mail: asbest321@gmail.com.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kon’kov, V.G., Kudrin, V.S., Narkevich, V.B. et al. The Effect of Noopept on the Content of Monoamines and Their Metabolites and Neurotransmitter Amino Acids in the Brain Structures of BALB/c and C57BL/6 Mice: A Comparative Study. Neurochem. J. 16, 161–167 (2022). https://doi.org/10.1134/S181971242202009X

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S181971242202009X

Keywords:

Navigation