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Neurochemical Journal

, Volume 12, Issue 1, pp 102–106 | Cite as

Thiol/Disulfide Homeostasis in Schizophrenic Patients

  • Burak Kulaksizoglu
  • Sibel Kulaksizoglu
Clinical Neurochemistry
  • 12 Downloads

Abstract

To determine serum thiol/disulfide homeostasis in schizophrenic patients. Serum native thiol, total thiol, and disulfide levels measuremented in the patients with 42 schizophrenia and 42 the healthy subjects. Serum native thiol, total thiol, and disulfide levels measuremented with a novel automated method. The thiol/disulfide ratio was also calculated. The Positive and Negative Syndrome Scale (PANSS) was used to assess the patients. The native thiol (p < 0.001) and total thiol (p < 0.001) levels, and the native thiol/total thiol (p = 0.018) ratio were significantly lower, whereas disulfide/native thiol (p = 0.002) and disulfide/total thiol (p = 0.002) ratio significantly increased in the schizophrenia patient group compared to the control group. A statistically significantly positive relationship was found between PANSS positive subscale with disulfide (r = 0.43, p = 0.01). Significantly positive relationships were found between PANSS total subscale with disulfide/total thiol (r = 0.308, p = 0.047). Our results suggest that the disulfide/thiol ratio is significantly greater in schizophrenia patients and disulfide/thiol ratio is closely related with the patients’ clinical symptoms.

Keywords

schizophrenia homocysteine methionine glutathione vitamin B12 folate 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  1. 1.Antalya Training and Research Hospital Psychiatry DepartmentAntalyaTurkey
  2. 2.Antalya Training and Research Hospital Biochemistry DepartmentAntalyaTurkey
  3. 3.Antalya Education and Research Hospital, Clinical Biochemistry Central Laboratory Ministry of Health, Antalya Egitim ve ArastirmaAntalyaTurkey

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