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Cholinergic mechanisms of headaches

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Abstract

Headache is one of the widespread pain syndromes with polyneurochemical mechanisms. Here, we review the involvement of the cholinergic neurotransmitter system in the pathophysiology of various forms of headaches. Data on the sources of cholinergic and parasympathetic innervations of intracranial structures and distribution of N- and M-cholinoreceptors of various subtypes within the trigeminovascular system and their roles in the acetylcholine (ACh) effects on brain circulation and processing of nociception in headache are reviewed. We present data on the algogenic and anti-nociceptive effects of ACh in the peripheral and central parts of the trigeminal nerve system and its presumably analgesic effects at the supraspinal level of the CNS. We discuss the ACh-dependent mechanisms of the anticephalalgia action of pharmacological and nonpharmacological approaches that are used for the headache treatment and the future perspectives of the use of cholinergic drugs.

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Abbreviations

4-DAMP:

4-diphenylacetoxy-N-methylpiperidine

7-TM-receptors:

7-Transmembrane Receptors, a family of metabotropic receptors

CGRP:

calcitonin gene-related peptide

GO:

ganglion oticum

GPP:

ganglion pterygopalatinum

NGC:

nucleus retucularis gigantocellularis

NL:

nucleus lacrimalis

NO:

nitric oxide

NOS:

NO-synthase

NRM:

nucleus raphe magnus

NSI:

nucleus salivatorius inferior

NSS:

nucleus salivatorius superior

NTS:

nucleus tracti solitarii

N-/M-AChR:

nicotinic/muscarinic acetylcholine receptor

PACAP:

pituitary adenylate cyclase-activating polypeptide

PAG:

periaqueductal grey matter

PHM:

peptide histidine-methionine

RVM:

rostral ventromedial medulla

SNAP-25:

25 kDa Synaptosomal Nerve-Associated Protein, a constituent of SNARE complex associated with a membrane of the nerve terminal

SNARE:

SNAp [Soluble N-ethylmaleimide-sensitive factor Attachment protein] REceptor, a group of proteins involved in fusion of intracellular transport vesicles with cellular membrane

SP:

substance P

STN:

spinal trigeminal nucleus

SUNCT:

Short-lasting Unilateral Neuralgiform headache attacks with Conjunctival injection and Tearing

SV2:

synaptic vesicular glycoprotein 2

TNC:

trigeminal nucleus caudalis

VIP:

vasointestinal peptide

ACh:

acetylcholine

BAT:

botulinum A toxin

TTH:

tension-type headache

NSAID:

non-steroid anti-inflammatory drugs

SCS:

spinal cord stimulation

DM:

dura mater

TCC:

trigeminocervical complex

CDH:

chronic daily headache

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Authors and Affiliations

  1. Val’dman Institute of Pharmacology, Pavlov First St. Petersburg State Medical University, ul. L’va Tolstogo 6-8, St. Petersburg, 197022, Russia

    A. Y. Sokolov, A. A. Murzina, A. V. Osipchuk & O. A. Lyubashina

  2. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. Y. Sokolov & O. A. Lyubashina

  3. Department of Neurology, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

    A. V. Amelin

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  1. A. Y. Sokolov
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  2. A. A. Murzina
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  3. A. V. Osipchuk
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  4. O. A. Lyubashina
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Original Russian Text © A.Y. Sokolov, A.A. Murzina, A.V. Osipchuk, O.A. Lyubashina, A.V. Amelin, 2017, published in Neirokhimiya, 2017, Vol. 34, No. 3, pp. 189–208.

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Sokolov, A.Y., Murzina, A.A., Osipchuk, A.V. et al. Cholinergic mechanisms of headaches. Neurochem. J. 11, 194–212 (2017). https://doi.org/10.1134/S1819712417020131

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