Skip to main content

Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders

Abstract

We present a comprehensive clinical and biological study of 46 patients with depressive disorder (F32-F33: depressive episode and recurrent depressive disorder) during pharmacotherapy. Neurohumoral factors (cortisol, brain-derived neurotrophic factor, serotonin, DHEA and its sulfated form) were determined in serum by ELISA. The severity of the current depressive episode was evaluated using the 17-point Hamilton Depression Rating Scale (HDRS-17); the pharmacotherapy efficacy was evaluated using the scale of the Clinical Global Impression (CGI Scale). We showed that before prescription of pharmacotherapy peripheral blood neurohumoral markers that characterize the state of stress-realizing and stress-limiting systems of the body may be considered as biological predictors of the effective pharmacotherapy of a current depressive episode and used as additional paraclinical examination methods. At higher concentrations of cortisol and serotonin associated with a decrease in the content of neurosteroid dehydroepiandrosterone, the high efficiency of the pharmacotherapy of depressive episode is predicted.

This is a preview of subscription content, access via your institution.

References

  1. Krasnov, V.N., Rasstroistva affektivnogo spektra (Affective Disorders), Moscow: Prakticheskaya Meditsina, 2011.

    Google Scholar 

  2. Jentsch, M.C., Van Buel, E.M., Bosker, F.J., Gladkevich, A.V., Klein, H.C., Oude, Voshaar R.C., Ruhe, H.G., Eisel, U.L.M., and Schoevers, R.A., Biomark. Med, 2015, vol. 9, no. 3, pp. 277–297.

    CAS  Article  PubMed  Google Scholar 

  3. Thase, M.E., Dialogues Clin. Neurosci, 2014, vol. 16, no. 4, pp. 539–544.

    PubMed  PubMed Central  Google Scholar 

  4. Uzbekov, M.G., Gurovich, I.Ya., and Ivanova, S.A., Sots. I klin. psikhiatr, 2016, vol. 26, no. 1, pp. 77–94.

    Google Scholar 

  5. Ryadovaya, L.A., Gutkevich, E.V., Stoyanova, I.Ya., and Ivanova, S.A., TSPU Bulletin, 2009, no. 3, pp. 49–53.

    Google Scholar 

  6. Bokhan, N.A., Ivanova, S.A., and Levchuk, L.A., Serotoninovaya sistema v modulyatsii depressivnogo i agressivnogo povedeniya (Serotoninergic System in the Modulation of Agression), Tomsk, 2013.

    Google Scholar 

  7. Markopoulou, K., Papadopoulos, A., Juruena, M.F., Poon, L., Pariante, C.M., and Cleare, A.J., Psychoneuroendocrinology, 2009, vol. 34, no. 1, pp. 19–26.

    CAS  Article  PubMed  Google Scholar 

  8. Rivera-Baltanas, T., Olivares, J.M., Calado-Otero, M., Kalynchuk, L.E., Martinez-Villamarin, J.R., and Caruncho, H.J., J. Affect Disord, 2014, vol. 163, pp. 47–55.

    CAS  Article  PubMed  Google Scholar 

  9. Eckert, A., Mikoteit, T., Beck, J., Hemmeter, U.M., Brand, S., Schmitt, K., Bischof, R., Delini-Stula, A., and Holsboer-Trachsler, E., European Psychiatry, 2016, vol. 33, p. 410.

    Article  Google Scholar 

  10. Yoshimura, R., Kishi, T., and Suzuki, A., Prog. Neuropsychopharmacol. Biol. Psychiatry, 2011, vol. 35, no. 4, pp. 1022–1025.

    CAS  Article  PubMed  Google Scholar 

  11. Morita, T., Senzaki, K., Ishihara, R., Umeda, K., Iwata, N., Nagai, T., Hida, H., Nabeshima, T., Yukawa, K., Ozaki, N., and Noda, Y., Hum. Psychopharmacol, 2014, vol. 29, no. 3, pp. 280–286.

    CAS  Article  PubMed  Google Scholar 

  12. Shutov, A.A. and Bystrova, O.V., Zhurn. Nevrol. i psikhiatr. im. S.S. Korsakova, 2008, no. 10, pp. 49–54.

    Google Scholar 

  13. Dzyuba, A.N., Khaustova, E.A., and Bezsheiko, V.G., Ukr. Med. chasopi, vol. 88, pp. 121–125.

  14. Levchuk, L.A., Vyalova, N.M., Simutkin, G.G., Ivanova, S.A., and Bokhan, N.A., Vestnik Ural’Skoi akademicheskoi meditsinskoi nauki, 2014, no. 3, pp. 217–219.

    Google Scholar 

  15. Levchuk, L.A., Vyalova, N.M., Ivanova, S.A., Simutkin, G.G., Lebedeva, E.V., and Bokhan, N.A., Bulletin of Experimental Biology and Medicine, 2015, vol. 158, no. 5, pp. 638–640.

    CAS  Article  PubMed  Google Scholar 

  16. Levchuk, L.A., Ivanova, S.A., Simutkin, G.G., Lebedeva, E.V., Vyalova, N.M., Losenkov, I.S., and Bokhan, N.A., RF Patent No. 2530635 (2014).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. A. Ivanova.

Additional information

Original Russian Text © L.A. Levchuk, N.M. Vyalova, G.G. Simutkin, N.A. Bokhan, S.A. Ivanova, 2017, published in Neirokhimiya, 2017, Vol. 34, No. 2, pp. 177–180.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Levchuk, L.A., Vyalova, N.M., Simutkin, G.G. et al. Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders. Neurochem. J. 11, 185–187 (2017). https://doi.org/10.1134/S1819712417020088

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1819712417020088

Keywords

  • depressive disorder
  • pharmacotherapy
  • neurohumoral system