Abstract
Lithium is used in the therapy of various psychoses based on its antidepressant and mood stabilizing properties. However it also exerted toxic side effects in long standing treatment. We studied the effect of lithium on brain oxidative stress status into healthy rat as well as the putative protection afforded by grape seed and skin extract, used as an antioxidant and anti-inflammatory agent. Lithium generated an oxidative stress characterized by increased lipoperoxidation and carbonylation, decreased antioxidant enzyme activities as catalase, superoxide dismutase and glutathione peroxidase. Furthermore lithium altered transition metals distribution and associated enzyme activities, increased intracellular mediators as H2O2, free iron, calcium, magnesium and calpain activity but decreased acetylcholinesterase activity. Lithium also disturbed brain lipidemia as evidenced by high triglyceride and cholesterol and low lipase activity. Almost all deleterious effects of lithium were normalized by grape seed and skin extract especially at the therapeutic doses of lithium. Grape seed and skin extract could be proposed as an efficient neuroprotectant to mitigate the adverse side effects of lithium.
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Schechter, L.E., Ring, R.H., Beyer, C.E., Hughes, Z.A., Khawaja, X., Malberg, J.E., and Rosenzweig-Lipson, S., NeuroRx., 2005, vol. 2, pp. 590–611.
Geddes, J.R., Burgess, S., Hawton, K., Jamison, K., and Goodwin, G.M., Am. J. Psychiatry, 2004, vol. 161, pp. 217–222.
Cipriani, A., Smith, K., Burgess, S., Carney, S., Goodwin, G., and Geddes, J., Cochrane Database Syst. Rev., 2006, vol. 4, p. CD003492.
Altamura, A.C., Buoli, M., and Mauri, M.C.., J. Clin. Psychopharmacol., 2011, vol. 31, pp. 661–663.
Machado-Vieira, R., Andreazza, A.C., Viale, C.I., Zanatto, V., Cereser, V., Jr., da Silva Vargas, R., Kapczinski, F., Portela, L.V., Souza, D.O., Salvador, M., and Gentil, V., Neurosci. Lett., 2007, vol. 421, pp. 33–36.
Halliwell, B., Drugs Aging, 2001, vol. 18, pp. 685–716.
Ahmad, M., Elnakady, Y., Farooq, M., and Wadaan, M., Biol. Pharm. Bull., 2011, vol. 34, pp. 272–277.
Bagchi, D., Bagchi, M., Stohs, Sj., Ray, S.D., Sen, C.K., and Preuss, H.G., Ann. NY Acad. Sci., 2002, vol. 957, pp. 260–270.
Ferruzzi, M.G., Lobo, J.K., Janle, E.M., Cooper, B., Simon, J.E., Wu, Q.L., Welch, C., Ho, L., Weaver, C., and Pasinetti, G.M.., J. Alzheimers. Dis., 2009, vol. 18, pp. 113–124.
Constant, J., Clin. Cardiol., 1997, vol. 20, pp. 420–424.
FDA agency response letter GRAS notice no. GRN000124. http//www.fda.gov/Food/Food ingredients Packaging/Generally Recognized as Safe GRAS/GRAS Listings/ucm 153940; htm. Accessed 1 June, 2011.
Singleton, V.L. and Rossi, J., Am. J. Enol. Vitic., 1965, vol. 16, pp. 144–158.
Dewanto, V., Wu, X., Adom, K.K., and Liu, R.H.., J. Agric. Food Chem., 2002, vol. 50, pp. 3010–3014.
Sun, B., Richardo da Silva, J.M., and Spranger, I.., J. Agric. Food Chem., 1998, vol. 46, pp. 4267–4274.
National Research Counci., Bethesda: National Institute of Health, 1985, vol. 20, pp. 85–123.
Draper, H.H. and Hadley, M., Methods Enzymol., 1990, vol. 186, pp. 421–431.
Levine, R.L., Garland, D., Oliver, C.N., Amici, A., Climent, I., Lenz, A.G., Ahn, B.W., Shaltiel, S., and Stadtman, E.R., Methods Enzymol., 1990, vol. 186, pp. 464–478.
Hartree, E.F., Anal. Biochem., 1972, vol. 48, pp. 422–427.
Ellman, G.L., Arch. Biochem. Biophys., 1959, vol. 82, pp. 70–77.
Tietze, F., Anal. Biochem., 1969, vol. 27, pp. 502–522.
Nakamura, W., Hosada, S., and Hayashi, K., Biochim. Biophys. Acta, 1974, vol. 358, pp. 251–261.
Aebi, H., 2nd ed., New York: Chemia Weinheium, 1974.
Misra, H.P. and Fridovich, I.., J. Biol. Chem., 1972, vol. 247, pp. 3170–3175.
Leardi, A., Caraglia, M., Selleri, C., Pepe, S., Pizzi, C., Notaro, R., Fabbrocini, A., De Lorenzo, S., Musicò, M., Abbruzzese, A., Bianco, A.R., and Tagliaferri, P., Br. J. Haematol., 1998, vol. 102, pp. 746–752.
Kakinuma, K., Yamaguchi, T., Kaneda, M., Shimada, K., Tomita, Y., and Chance, B., J. Biochem., 1979, vol. 86, pp. 87–95.
Stern, J. and Lewis, W.H., Clin. Chim. Acta, 1957, vol. 2, pp. 576–580.
Ellman, G.L., Courtney, K.D., Andres, V., Jr., and Feather-Stone, R.M., Biochem. Pharmacol., 1961, vol. 7, pp. 88–95.
Bergmeyer, H.U.., Z. Klin. Chem. Klin. Biochem., 1975, vol. 13, pp. 507–508.
Sasaki, T., Kikuchi, T., Yumoto, N., Yoshimura, N., and Murachi, T.., J. Biol. Chem., 1984, vol. 259, pp. 12489–12494.
Worthington Biochemical Corporation, Worthington Enzyme Manual, Freehold, N.J., USA: Worthington Biochemical Corp., 1977, vol. 74–75.
Santoro, J.C., Harris, G., and Sitlani, A., Anal. Biochem., 2001, vol. 289, pp. 18–25.
Humbert, G., Guingamp, M.F., and Linden, G., J. Dairy Res., 1997, vol. 64, pp. 465–469.
Folch, J., Lees, M., and Sloane Stanley, G.H.., J. Biol. Chem., 1957, vol. 226, pp. 497–509.
Castegna, A., Palmieri, L., Spera, I., Porcelli, V., Palmieri, F., Fabis-Pedrini, M.J., Kean, R.B., Barkhouse, D.A., Curtis, M.T., and Hooper, D.C., Neuroscience, 2011, vol. 185, pp. 97–105.
Morello, M., Zatta, P., Zambenedetti, P., Martorana, A., D’Angelo, V., Melchiorri, G., Bernardi, G., and Sancesario, G., Brain Res. Bull., 2007, vol. 74, pp. 406–415.
Erikson, K.M., Dorman, D.C., Fitsanakis, V., Lash, L.H., and Aschner, M., Biol. Trace Elem. Res., 2006, vol. 111, pp. 199–215.
Jing, P., Zhang, J.Y., Ouyang, Q., Wu, J., and Zhang, X.J., Chem. Biol. Interact., 2013, vol. 203, pp. 309–313.
Oliveira Rda, L., Seibt, K.J., Rico, E.P., Bogo, M.R., and Bonan, C.D., Neurotoxicol. Teratol., 2011, vol. 33, pp. 651–657.
Fernandes, S.P., Dringen, R., Lawen, A., and Robinson, S.R., Neurosci. Lett., 2011, vol. 490, pp. 27–30.
Pohanka, M., Environ. Toxicol. Pharmacol., 2014, vol. 37, pp. 455–459.
Crespo-Biel, N., Camins, A., Pallàs, M., and Canudas, A.M., Neuropharmacology, 2009, vol. 56, pp. 422–428.
Ren, M., Senatorov, V.V., Chen, R.W., and Chuang, D.M., Proc. Natl. Acad. Sci. USA, 2003, vol. 100, pp. 6210–6215.
Bian, Q., Shi, T., Chuang, D.M., and Qian, Y., Brain Res., 2007, vol. 1184, pp. 270–276.
Greenwood, A.F. and Jope, R.S., Brain Res., 1994, vol. 636, pp. 320–326.
Machado, V.M., Morte, M.I., Carreira, B.P., Azevedo, M.M., Takano, J., Iwata, N., Saido, T.C., Asmussen, H., Horwitz, A.R., Carvalho, C.M., and Araújo, I.M., Front. Cell Neurosci., 2015, vol. 9, p.22.
Lee, T.M., Lin, S.Z., and Chang, N.C., Free Radic. Biol. Med., 2014, vol. 77, pp. 71–81.
Li, H., Huang, K., Liu, X., Liu, J., Lu, X., Tao, K., Wang, G., and Wang, J., Oxid. Med. Cell Longev., 2014, vol. 2014, p. 241864.
Ozkul, A., Sair, A., Akyol, A., Yenisey, C., Dost, T., and Tataroglu, C., Neurochem. Res., 2014, vol. 39, pp. 853–861.
Bardini, G., Rotella, C.M., Giannini, S., Harsch, I.A., and Weimann, A., Metabolism, 2009, vol. 58, pp. 735–737.
Aliyazicioglu, R., Kural, B., Colak, M., Karahan, S.C., Ayvaz, S., and Deger, O., Tohoku J. Exp. Med., 2007, vol. 213, pp. 79–87.
Cao, J., Feng, X.X., Yao, L., Ning, B., Yang, Z.X., Fang, D.L., and Shen, W., Dig. Dis. Sci., 2014, vol. 59, pp. 346–357.
Kielczykowska, M., Kocot, J., Kurzepa, J., Lewandowska, A., Zelazowska, R., and Musik, I., Biol. Trace Elem. Res., 2014, vol. 158, pp. 359–364.
Rose, C.F., Verkhratsky, A., and Parpura, V., Biochem. Soc. Trans., 2013, vol. 41, pp. 1518–1524.
Milatovic, D., Gupta, R.C., and Aschner, M., Sci. World J., 2006, vol. 6, pp. 295–310.
Páramo, B., Montiel, T., Hernández-Espinosa, D.R., Rivera-Martínez, M., Morán, J., and Massieu, L., Int. J. Biochem. Cell Biol., 2013, vol. 45, pp. 2596–2604.
Scola, G., Laliberte, V.L., Kim, H.K., Pinguelo, A., Salvador, M., Young, L.T., and Andreazza, A.C., Neurochem. Int., 2014, vol. 79, pp. 12–19.
Charradi, K., Elkahoui, S., Karkouch, I., Limam, F., Hassine, F.B., and Aouani, E., Neurochem. Res., 2012, vol. 37, pp. 2004–2013.
Safwen, K., Selima, S., Mohamed, E., Ferid, L., Pascal, C., Mohamed, A., Ezzedine, A., and Meherzia, M., Int. J. Stroke, 2015, vol. 10, pp. 415–424.
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Mezni, A., Aoua, H., Limam, F. et al. Neuroprotective effect of grape seed and skin extract on lithium-induced oxidative stress in healthy rat brain. Neurochem. J. 11, 85–94 (2017). https://doi.org/10.1134/S1819712417010093
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DOI: https://doi.org/10.1134/S1819712417010093