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Neurochemical Journal

, Volume 10, Issue 3, pp 195–198 | Cite as

Immunological study of freshwater crayfish nervous tissue for receptors for neurotrophins and ciliary neurotrophic factor

  • M. S. KolosovEmail author
  • M. A. Komandirov
  • V. V. Terent’ev
  • A. V. Shitov
  • R. I. Kiroy
  • O. E. Kurayan
Experimental Articles

Abstract

Neurotrophic factors support survival of neural and glial cells under injuring impacts to mammalian nerve tissue. In invertebrates elements of neurotrophic signaling system (receptors and ligands) were not found for a long time, while phenomenology indicates that cytoprotective neuroglial communication involving neurotrophins, probably, occurs. Presence of proteins immunologically similar to receptors of neurotrophic factors—NGF, BDNF and CNTF—in freshwater crayfish nerve tissue was studied in this work. The proteins similar to low affinity neurotrophins receptor p75, as well as similar to ciliary neurotrophic factor receptor CNTFR were found. In the stretch receptor organ of freshwater crayfish immunostaining for p75 receptors was mainly localized in the receptor neurons, whereas immunostaining for CNTFR was most pronounced in certain glial cells.

Keywords

receptors for neurotrophic factors neuroglial communication 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • M. S. Kolosov
    • 1
    Email author
  • M. A. Komandirov
    • 2
  • V. V. Terent’ev
    • 3
  • A. V. Shitov
    • 3
  • R. I. Kiroy
    • 1
  • O. E. Kurayan
    • 1
  1. 1.Southern Federal UniversityRostov-on-DonRussia
  2. 2.Rostov Research Institute of OncologyRostov-on-DonRussia
  3. 3.Institute of Fundamental Problems of Biology RASPushchinoRussia

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